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발암물질이 배양 생쥐 포세포에 미치는 세포유전학적 영향
한사숙,정영란,정용재 ( Sah Sook Hahn,Young Lan Chung,Yong Jai Chung ) 한국유전학회 1981 Genes & Genomics Vol.3 No.1
The present study was undertaken in an attempt to compare sensitivity of mutagenecity of two kinds of carcinogens: dimethylnitrosamine(DMN), diethylnitrosamine(DEN) on chromosome level by examining metaphase chromosomal aberrations and sister chromatid exchanges (SCEs). The five kinds of dosages of DMN and DEN (1×10-6, 5×10-6, 1×10-5, 5×10-5 and 1×10-4 M) were applied to the cultured embryonic cells of mouse and the results thus obtained are presented below: 1. The types of chromosome aberrations were found to be mainly chromatid gaps, chromosome breaks, chromosome exchanges and dicentrics. Chromosome aberrations showed increase of frequencies as dosage of carcinogen increased and the total chromosome aberrations were detected to be higher in DMN than in DEN treatment. 2. Cells treated with only BUdR showed 7.06±0.34/cell of SCEs and cells treated with DMN and DEN showed increase of and 2.06 times of SCE production from BUdR treated control respectively. SCE frequencies increased as dosages of carcinogens increased and it was also shown that DMN treatment produced more SCEs than DEN did. 3. The SCE test method was manifested to be approximately 15 times more sensitive than conventional metaphase chromosome aberration score method. 4. The DMN was also found to be more potent agent for inducing chromosome aberrations and SCEs than DEN.
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