http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
흡연이 기관지폐포세척액내 Fibronectin 의 생성에 미치는 영향
박춘식(Choon Sik Park),정연태(Yun Tae Jung),이승원(Seung Won Lee),이문성(Mun Sung Lee),김영순(Young Soon Kim),이상무(Sang Moo Lee) 대한내과학회 1988 대한내과학회지 Vol.34 No.3
N/A Fibronectin (FN) is a large, dimeric glycoprotein found in plasma, other biological fluid and tissues and has a function of important non-immune opsonin. Although the origin of plasma FN remains obsclear, it is synthesized by a variety of cultured cells including human alveolar macrophage, which can be activated by smoking. To evaluate the effect of smoking on FN production by alveolar macrophage, FN concentration was measured in serum and bronchoalveolar lavage (BAL) fluid of 10 smokers and the results were compared with those of non-smokers. 1) BAL FN concentration of smokers was not different from that of non-smokers, but the ratio of FN to albumin in BAL fluid was higher in smokers than in non-smokers (16.04±2.3 ug/mg-Alb vs 10.0±1.2 ug/ mg-Alb, p<0.025). 2) Serum FN concentration and the ratio of FN to albumin in BAL of smokers were not different from those of non-smokers (112.1±15.5ug/ml and 2.89±0.33 ug/mg-Alb vs 99.6±15.4 ug/ml and 2.82±0.44 ug/ mg-Alb, p>0.05). 3) The ratio of BAL fluid to serum-FN to Alb ratio [BAL(FN/Alb)/serum(FN/Alb)] was above 1.0 in smokers and non-smokers and was not different from between smokers and non-smokers (5.66±0.67 vs 4.64±0.98, p>0.05). 4) The concentration of BAL FN per 105 cells of alveolar macrophage had higher tendency in smokers than non-smokers and the correlation between BAL-FN concentration and number of alveolar macrophage was not significant (5.09±1.80 ug/105 cells vs 3.83±0.99 ug/ 105 cells, p>0.05. r=0.22, p>0.05). We conclude that FN is actively secreted into intra-alveolar lumen and smoking might affect FN production through alveolar macrophage activation.
박춘식(Choon Sik Park),정연태(Yun Tae Jung) 대한내과학회 1988 대한내과학회지 Vol.34 No.3
N/A Cells obtained by bronchoalveolar lavage (BAL) from the normal lung of localized pulmonary diseases were analysed using monoclonal antibodies. The results were that 1) The percentages of T-lymphocyte, T-helper cell and T suppressor cell in BAL were not different from those in peripheral blood mononuclear cell (PRM), 2) the percentage of B- lymphocyte showed highter tendency in BAL compared to in PBM (9.3+3.1% vs 4.7+3.2%, p>0.05), 3) HLA-DR expression of T-lymphocyte was highter in BAL than in PBM (4.25+3.15% vs 1.28+1.75% p<0,05) and 4) macrophage obtained from BAL also showed higher expression rate of HLA-DR compared to monocyte from PBM(88.9+7.17% vs 61.9+24.0% p<0.05). We concluded that cells obtained from the bronchoalveaolar space were more developed in terms of immune status compared to those from PBM.