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신증후군출혈열 위험지역 감염매개 동물의 유전자 분석을 통한 감염지역 식별
김유진 ( Yujin Kim ),송진원 ( Jin-won Song ),김원근 ( Won-keun Kim ),이승호 ( Seung-ho Lee ),정재훈 ( Jaehun Jung ),오홍상 ( Hongsang Oh ),정수관 ( Sookwan Jeong ) 국군의무사령부 2018 대한군진의학학술지 Vol.49 No.1
Objectives; ROK AFMC has conducted complete epidemiological survey on HFRS patients since 2016 ’after a soldier death caused by HFRS at a unit in Pochen, Gyeonggi-do in 2015‘. By collecting vector animals at the same time, purpose of this study is to prevent the reoccurrence of HFRS patients by identifying infected areas. Methods; Identify expected habitats of rodents which are a vector of hantaviruses on the basis of HFRS definite diagnosis report from 2017 March to 2018 February and ask Korea University to analyze samples. Detect a gene by nested PCR for seropositive samples after conducting antibody tests for hantaviruses with indirect immunofluorescence assay in the laboratory. Results; Collected samples by 10 times in HFRS endemic areas and captured a total of 175 rodents. A total of 144 were Apodemus agrarius, 16 were Myodes regulus, 13 were Crocidura lasiura and one sample was Mus musculus. A total of 22 hantavirus antibody-positive samples were found and the hantavirus-specific gene was detected in 11 out of 22 samples in the six areas where the rodents were captured. Conclusions; Demonstrate the outcome of hantavirus genes from HFRS patients forms genetic clustering with that from A. agrarius. Also, identify highly HFRS risk areas and conduct action to prevent additional patient occurrence at the same time.