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천식에서 외부 저항 부하와 기관지수축 유발에 의한 호흡곤란 인지능 측정 비교 연구
최인선 ( Inseon S. Choi ),정성훈 ( Seong Hoon Cheong ),정대호 ( Dae Ho Cheong ),이우진 ( Woo Jin Lee ),한의령 ( Eui Ryoung Han ) 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.2
Background: Since blunted perception of dyspnea may predispose to fatal asthma attacks, dyspnea perception should be measured in severe asthma. Few studies have compared the testing methods. Objective: To investigate whether the degree of dyspnea perception depends on the testing method in asthma. Method: The Borg scale-based dyspnea perception scores during breathing through an inspiratory muscle trainer, and during bronchoprovocation tests using histamine or methacholine were measured in asthma patients and normal volunteers. The relationships between Borg scores and atopy markers were determined. Result: The △Borg scores induced by the external resistive loads were significantly lower in subjects with moderateto-severe airway hyperresponsiveness (AHR) to histamine than in those with negative AHR (P=0.021). Among the patients with AHR to both histamine and methacholine (n=19), the △Borg scores/△lung function ratio induced by histamine was significantly higher than that by methacholine (15.6±2.3 vs. 9.5±2.1, P<0.05). The load-induced △Borg scores were significantly related to serum total IgE levels (r=0.541, P<0.05). Conclusion: Dyspnea perception depends on AHR severity. Histamine induces more severe dyspnea than methacholine, and allergy may affect dyspnea perception. Dyspnea perception vary according to the testing methods. (Korean J Asthma Allergy Clin Immunol 2007;27:111-117)