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잔나비걸상버섯 수용성물질의 항인플루엔자바이러스 작용과 인터페론과의 병용효과
정선식(Sun Sik Jeong),어성국(Seong Kug Eo),김영소(Young So Kim),한성순(Seong Sun Han) 대한약학회 1999 약학회지 Vol.43 No.4
EA. the water soluble substance, was prepared from the carpophores of Elfvingia applanata(Pers.) Karst. Anti-influenza A virus (anti-Flu A) activity of EA was examined in Vero cells by plaque reduction assay in vitro. And the combined antiviral effects of EA with interferon (IFN) alpha and gamma were examined on the multiplication of Flu A. EA showed a concentration-dependent reduction in the plaque formation of Flu A with 50% effective concentration (EC50) of 1.50mg/ml. The results of combination assay were evaluated by the combination index (CI) that was analysed by the multiple drug effect analysis. The combination of EA with IFN alpha on Flu A showed more potent synergism with CI values of 0.50~0.52 of 50%, 70%, 90% effective levels than that with IFN gamma with CI values of 0.82~0.99.
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폐염간균에 대한 Quinolone계 약제의 항균작용에 미치는 Rifampin의 영향
류필열,정문태,신부안,정선식,안태휴 대한화학요법학회 1990 대한화학요법학회지 Vol.8 No.2
Antimicrobial activities of nalidixic acid(NA),norfloxacin(NX), oxolinic acid(OA), pefloxacin(PX), pipemidic acid(PA), oxacillin, cefotaxime(CFT), cephaloridine, cefazoline, moxalactam(MX), gentamicin, amikacin(AK) and rifampin(RP) were compared by the agar dilution method against 31 strains of K. pneumoniae isolated from various clinical spectimens. And then combined activities of RP with each of the quinolones (NA, MX, OAA, PX, and PA) against the test strains were measured by checkerboard dilution and time-killing methods. The growth inhibitory activities of PX, NX, OA, MX and AK were exellent, and those of PA, NA, RP and CFT were moderate, while the other's being almost negligible. The bactericidal activity of PX was more active than that of the other quinolones. Increasing concentrations of the quinolones resulted in a parallel increment of killing rate. However, when levels of quinolones were excessive beyond the most effective bactericidal ones, the bactericidal activity was decreased. In the combined growth inhigitory tests of RP with quinolones by checkerboard agar dilution method, synergistic and additive effects were rarely observed, and antagonism was noticed among the combinations in the following order: RP-NA, 22 strains (71%); RP-PA, 21 strains (67.7%); RP-OA, 17 strains (54.8%); RP-PX, 15 strains (48.4%) and RP-NA, 14 strains (45.2%). In the combined bactericidal tests measured by time-killing method, RP was found to reduce the activities of all five quinolones tested. And the gradual increasing of RP dose was revealed to reduce progressively the bactericidal action of the quinolones. But when RP was added to quinolones after 1 hour of incubations, the bactericidal activities were not affected.
ScienceON
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