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H₂O₂에 의한 Tight Junction Protein Occludin의 변화
정봉수 외 중앙대학교 의과대학 의학연구소 2006 中央醫大誌 Vol.31 No.1·2·3
Cerebral microvessel endothelial cells that form blood-brain barrier (BBB) have tight junction for maintaining brain homeostasis. Occludin, one of tight junction proteins, is crucial for BBB function. H₂O₂-induced occludin changes and its effects on bovine brain BBB endothelial cells were examined in this study. The decrease of transelectrical endothelial resistance (TEER) by H₂O₂ was due to occludin redistribution. Occludin disappeared in a dose dependent manner from intercellular junction in immunofluorescent study. But the total amounts of occludin and cell membrane bound occludin did not changed by H₂O₂. These showed that the loss of function of BBB was not due to the decrease of occludin or the internalization of occludin into cytoplasm. Occludin was limited within cell membrane of endothelial cell and H₂O₂ caused the redistribution of occludin within cell membrane. These data strongly suggest that H₂O₂-mediated loss of BBB function involves the loss of tight junction integrity through occludin redistribution.