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7-Chloro-4-nitro-benzo[1,2,5]oxadiazole 1-oxide의 CDK4 활성저해
전용진(Young Jin Jeon),고종희(Jong Hee Ko),연승우(Seung Woo Yeon),김태용(Tae Yong Kim) 대한약학회 2006 약학회지 Vol.50 No.1
The activation of cyclin dependent kinase 4 (CDK4) is found in more than half of all human cancers. Therefore, CDK4 is an attractive target for the development of a novel anticancer agent. For mass screening of CDK4 inhibitor, we set up in vitro kinase assay for CDK4 activity using a cyclin D1-CDK4 fusion protein, which is constitutively active and exhibits enhanced stability. From the screening of representative compound library of Korea Chemical Bank, we found that 7-chloro-4-nitro-benzo[1,2,5]oxadiazole 1-oxide (FBP-1248) selectively inhibited CDK4 activity in vitro by ATP competitive manner. This compound prevented the phosphorylation of retinoblatsoma tumor suppressor protein, Rb, and inhibited cell growth through cell cycle arrest. In summary, we developed an efficient assay system for CDK4 activity in vitro and identified the CDK4 inhibitory compound, FBP-1248.
허베이 스피리트호 유류 유출이 초등학생들의 알레르기 질환 유병률에 미친 영향
전용진 ( Yong-jin Jeon ),장봉기(교신저자) ( Bong-ki Jang ),이익진 ( Ik-jin Lee ),이종화 ( Jong-wha Lee ),손부순 ( Bu-soon Son ),정해관 ( Hae-kwan Cheong ),하미나 ( Mi Na Ha ),최영현 ( Young-hyun Choi ),박명숙 ( Myung Sook Park ),이승 대한보건협회 2016 대한보건연구 Vol.42 No.2
연구목적: 본 연구는 2007년 12월 7일 크레인 부선과 유조선 허베이 스피리트호가 충돌해 원유가 유출된 사고에 따른 인접한 지역 내 초등학생을 대상으로 유류노출과 알레르기 질환과의 관련성을 알아보았다. 연구방법: 지리정보 시스템을 활용하여 사고 지점으로부터 거주지까지 20 km 안쪽에 거주하는 학생을 고노출군, 20 km초과 거주자를 저노출군으로 분류하고, 방제작업 참여여부에 따라 노출수준을 분류하여 ISAAC 설문과 피부단자 검사를 사고1년 6개월이 지난 시점에서부터 실시하였다. 연구결과: 조사 대상자의 지난 12개월 동안의 알레르기 증상경험 유병률은 천식이 9.4%, 알레르기성 비염 39.1%, 알레르기성 피부염 17.0%, 알레르기성 결막염 13.6%로 나타났다. 알레르기성 질환에 영향을 줄 수 있는 다른 환경요인을 통제하여 유출 유류 노출 강도에 따른 영향만을 보기 위하여 혼란요인을 보정한 후 분석한 결과, 사고지점으로부터 거주지까지의 거리에 따른 지난 12개월 동안의 알레르기성 비염의 교차비(odds ratio)가 저노출군보다 고노출군에서 1.88배(95% CI: 1.08 -3.29) 높은 것으로 나타났다(p<0.05). 알레르기성 질환에 영향을 줄 수 있는 다른 요인을 보정한 후, 방제작업 참여유무에 따른 알레르기성 질환 유병률의 차이를 분석한 결과, 지난 12개월 동안의 알레르기성 비염의 교차비가 미방제작업군보다 방제작업군에서 1.93배(95% CI: 1.12 - 3.30) 높은 것으로 나타났다(p<0.05). 결론: 초등학생의 알레르기 질환 중 알레르기성 비염의 경우 노출군에서 유의하게 높은 위험도를 나타내었으며, 전체적으로 유류 유출 피해지역에 거주하는 초등학생의 알레르기 질환의 유병률이 높은 것으로 보아 유류 유출이 초등학생의 알레르기성 비염 발생에 일부 영향을 미쳤을 것으로 생각된다. Objective: The relationship between the degree of oil spill exposure and the allergy prevalence rate of elementary school child living nearby the spot where the crude oil was spilled from the collision between the Korean crane barge and registered oil tanker Hebei Spirit on December 7, 2007. Methods: The research was conducted by dividing the subjects into two groups of the highly exposed and the low exposed according to the distance from the point of accident to their residence, and categorizing the oil exposure degree depending on the participation in clean-up works, with the ISAAC questionnaire and skin prick testing. Results: The allergy prevalence rate of the subjects for the last 12 months stood at 9.4% for asthma, 39.1% for allergic rhinitis, 17.0% for atopic dermatitis, 13.6% for allergic conjunctivitis. The study revised general confusion factors for allergic to analyze environmental factors that may influence allergic. In terms of the prevalence rate of allergic rhinitis by distance, the highly exposed group suffered allergic rhinitis 1.88 times (95% CI: 1.08 - 3.29) more than the low exposed group for the past 12 months, with significant relationship (p<0.05). In terms of the rate by participation in clean-up activities, the participated group experienced allergic rhinitis 1.93 times (95% CI: 1.12 - 3.30) more compared to the other (p<0.05). Conclusion: This study that the allergic diseases of the elementary school child living in the oil spill area would have posed a threat to their health.
W-Ni-Fe 중합금의 기계적 특성에 미치는 Fe7W6상(μ-phase)의 영향
전용진 ( Yong Jin Jeon ),김세훈 ( Se Hoon Kim ),김영도 ( Young Do Kim ) 대한금속재료학회(구 대한금속학회) 2011 대한금속·재료학회지 Vol.49 No.9
W-Ni-Fe heavy alloys have been used in various fields, such as kinetic energy penetrators and radiation shielding materials, due to their high density and good mechanical properties. In this study, the sintering of W-Ni-Fe alloys with various Ni/Fe ratios was demonstrated to improve the mechanical properties and penetration capabilities of heavy alloys by formation of interfacial phase. The microstructural changes and the mechanical properties of the W-Ni-Fe alloys after liquid-phase sintering were investigated. The Vickers hardness and tensile strength of the 95W1.3Ni3.7Fe sample, which had coated W grains by Fe7W6 phase (μ-phase), were 450 Hv and 1560 MPa, respectively. As a result, enhancement of the mechanical properties was considered to have uniformly generated μ-phase around W grains.
경수손상환자들의 폐기능 향상을 위한 흡기 및 호기 호흡운동 방법의 효과 비교
전용진(Yong Jin Jeon),오덕원(Duck Won Oh),김경모(Kyung Mo Kim),이영정(Young Jung Lee) 한국전문물리치료학회 2010 한국전문물리치료학회지 Vol.17 No.1
This study aimed to compare 2 protocols recommended to patients with chronic cervical cord injury : each protocol included breathing exercises (inhalation-oriented or exhalation-oriented) and facilitation maneuver for accessory respiratory muscles. Seventeen patients with chronic cervical cord injury volunteered to participate exercise group (IOBEG) and exhalation-oriented breathing exercise group (EOBEFG), consisting of 8 and p patients, respectively. Patients in the IOBEG performed inspiratory exercises using intermittent positive pressure breathing devices, while those in the EOBEG performed expiratory exercises using incentive spirometry. All exercises were performed by the subjects twice a day for 4 weeks, with each session lasting an average of 20 min. The outcomes were assessed on the basis of the pre- and post-treatment values of vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and FEV1/FVC. In the IOBEG, no significant differences were observed between the pre- and post-treatment values of any of the measured variables (p>.05); however, in the EOBEG, significant improvement was noted in the VC, FVC, FEVI (p>.05) after the treatment. In addition, the rates of change in the values of VC, FVC, and FEV1 differed significantly between the 2 groups (p<.05). These findings suggest that the EOBEs can enhance respiratory function and are clinically feasible in patients with chronic cervical cord injury. further studies will be undertaken to evaluate the clinical application of these findings.
알칼리 표면개질을 통한 메조포러스 알루미늄 하이드록사이드 필름 형성 기구
서영익,전용진,이영중,김대건,이규환,김영도,Seo, Young-Ik,Jeon, Yong-Jin,Lee, Young-Jung,Kim, Dae-Gun,Lee, Kyu-Hwan,Kim, Young-Do 한국재료학회 2010 한국재료학회지 Vol.20 No.2
In this study, a new, relatively simple fabrication method for forming a mesoporous $Al(OH)_3$ film on Al substrates was demonstrated. This method, i.e., alkali surface modification, was simply comprised of dipping the substrate in a $5\times10^{-3}$ M NaOH solution at $80^{\circ}C$ for one minute and then immersing it in boiling water for 30 minutes. After alkali surface modification, a mesoporous $Al(OH)_3$ film was formed on the Al substrate, and its chemical state and crystal structure were confirmed by XPS and TEM. According to the results of the XPS analysis, the flake-like morphology after the alkali surface modification was mainly composed of $Al(OH)_3$, with a small amount of $Al_2O_3$. The mesoporous $Al(OH)_3$ layer was composed of three regions: an amorphousrich region, a region of mixed amorphous and crystal domains, and a crystalline-rich region near the $Al(OH)_3$ layer surface. It was confirmed that the stabilization process in the alkali surface modification strongly influenced the crystallization of the mesoporous $Al(OH)_3$ layer.