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Flavone Attenuates Vascular Contractions by Inhibiting RhoA/Rho Kinase Pathway
백인지,전수분,송민지,양은예,손의동,김인겸 대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.3
Our previous study demonstrated that flavone inhibits vascular contractions by decreasing the phosphorylation levelof the myosin phosphatase target subunit (MYPT1). In the present study, we hypothesized that flavone attenuates vascular contractions through the inhibition of the RhoA/Rho kinase pathway. Rat aortic rings were denuded of endothelium, mounted in organ baths, and contracted with either 30 nM U46619 (a thromboxane A2 analogue) or 8.0 mM NaF 30 min after pretreatment with either flavone (100 or 300μM) or vehicle. We determined the phosphorylation level of the myosin light chain (MLC20), the myosin phophatase targeting subunit 1 (MYPT1) and the protein kinase C-potentiated inhibitory protein for heterotrimeric myosin light chain phophatase of 17-kDa (CPI17) by means of Western blot analysis. Flavone inhibited, not only vascular contractions induced by these contractors, but also the levels of MLC20 phosphorylation. Furthermore, flavone inhibited the activation of RhoA which had been induced by either U46619 or NaF. Incubation with flavone attenuated U46619- or NaF-induced phosphorylation of MYPT1Thr855 and CPI17Thr38, the downstream effectors of Rho-kinase. In regards to the Ca2+-free solution, flavone inhibited the phosphorylation of MYPT1Thr855 and CPI17Thr38, as well as vascular contractions induced by U46619. These results indicate that flavone attenuates vascular contractions, at least in part, through the inhibition of the RhoA/Rho-kinase pathway.
OB-38 : Mirror Syndrome associated with fetal leukemia
유슬기,이지연,전수분,김근아,정은주,이수정,나성훈,황종윤 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
Mirror syndrome describes the association of fetal and placental hydrops with maternal edema. It was first described in association with fetal hydrops caused by rhesus isoimmunization, and lately, in association with variable etiologies of nonimmunological fetal hydrops. This report is the first case of typical mirror syndrome associated with fetal hydrops caused by fetal leukemia. In this case, Down syndrome and fetal leukemia (acute megakaryoblastic leukemia) were diagnosed at28 weeks and two days` gestation. Without accompanied with heart anomaly or lymphatic system defect, Down syndrome hardly cause fetal hydrops itself. So, we can conclude that this fetal hydrops and mirror syndrome were resulted from fetal leukemia. In conclusion, the present case is the first reported case of mirror syndrome resulting from fetal leukemia. We suggest that fetal leukemia can be a important cause of mirror syndrome.
OB-48 : A study on the postpartum symptoms and their related factors in Korea
이지연,정은주,김근아,전수분,유슬기,이수정,국송이,황종윤 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: This study was aimed to identify physical and mental state of women after delivery, to investigate the factors that influence those, and to examine the effects of postpartum care performance, which is traditionally believed appropriate care in Korea, on her physical and mental status. 방법: Total 148 women who visited our hospital for postpartum check-up on the 2nd or 6th week after delivery were selected. We researched about postpartum care methods using questionnaire and made women self-evaluate on the postpartum symptoms. Depression was evaluated using BDI. 결과: Average point of the 27 postpartum symptoms 2.70 pts. (1= very good to 5= very bad). Seventy-two women had depression. Factors related to the postpartum symptoms and depression were smoking before pregnancy, low marital satisfaction, bad mood during and after pregnancy, bad support by husbands and bad quality of sleep during puerperium. Treating joints of hands carefully when milking breasts, and avoiding to squat down demonstrated negative correlation with the average point of the postpartum symptoms. Multivariate linear regression analysis showed that mood during puerperium and BDI points were significant factors were related to the average point of postpartum symptoms and that degree of support by husbands and mood during pregnancy were statistically related with depression. 결론: Many women complained postpartum discomfort. Although some postpartum care methods which have been traditionally believed appropriate care in Korea can be helpful to women`s recovery, most of them can`t. We confirmed that physical symptoms and depression are closely related to each other.