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인슐린비의존성 당뇨병환자에서 혈청 4 형 Collagen - 7S 의 의의
김영태(Young Tae Kim),한영찬(Young Chan Han),이정해(Jeong Hae Lee),김진곤(Jin Gon Kim),장태종(Tai Jong Jang),김윤권(Youn Kwon Kim),김소연(So Yon Kim),이권전(Gwon Jun Lee) 대한내과학회 1995 대한내과학회지 Vol.48 No.6
N/A Objectives: Thickening of basement membrane in capillaries and small vessels is a characteristic change in diabetic microangiopathy. It is improtant to observe dynamics of basement membrane metabolism in progression of this complication. Recently the component of basement membrane, collagen type IV-7S, can be detected in human sera by radioimmunoassays, Serum concentrations of collagen type IV was increased in diabetic patients and streptozotocin-induced diabetic rats. For the assessment of diabetic complication, we measured serum collagen type IV levels in non-insulin-dependent diabetic patients, comparing them with complications and durations of diabets mellitus. Methods: We measured serum collagen type IV levels in 94 non-insulin-dependent diabetic patients with or without clinical signs of retinopathy, nephropathy and in 32 healthy subjects without any serologic abnormality. We compared serum collagen type IV levels with degrees of complications and durations of diabets mellitus, Results: Serum concentrations of collagen type IV were significantly higher in diabetic patients than in healthy subjects. Serum collagen type IV levels were increased in patients with proteinuria, especially higher in patients with microproteinuria than in patiens without microproteinuria. Serum collagen type IV levels in patients with macroproteuinuria were significantly higher than in patients with microproteinuria. In patients with diabetic retinopathy, serum collagen type IV levels were significantly increased. Patients with proliferative retinopathy showed significant high levels of serum collagen type IV. Serum concentrations of collagen type IV were increased proportionately to the length of duration of diabetes mellitus. Conclusion: Serum collagen type N seems to be a useful, nonivasive, reproducible marker for assessment of the activity or progression of diabetic microangiopathy.
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