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한약이 임신중 태아에 미치는 영향(III) : 한약 및 한약 처방이 돌연변이원성과 염색체이상에 미치는 효과
김동현,이영경,김남재,장존복,송병기 경희대학교 동서의학연구소 2000 東西醫學硏究所 論文集 Vol.2000 No.-
Oriental herbal medicines were examined for mutagenicity in the reverse mutation test on Salmonella typimurium TA98/00 and chromosomal aberration test on cultured mammalina cells (Chinese hamster cell lines). The reverse mutation test was performed by a plate incorporation method with or without a metabolic activation system (S9 mix). Antaeeum, Aurantii Fructus and Kyoaekungkuetang significantly increased revertivle colonies on Salmonella typimurium TA 98 under the condition without S9 mix. Bojungikkitang significantly increased revertible colonies on Salmonella typimurium TA 100 under the condition with S9 mix than under the condition without S9 mix. The other tested herbal medicines did not significantly increased revertible colonies on any of the test strains under the condition with or without S9 mix. In the chromosomal aberration test. most tested herbal medicines did not significantly increased the number of aberrant cells under the conditions with S9 mix at concentrations of 1mg/ml, compared with the vehicle control. However, Gelatinum, Artemisiae Asiaticae Herba and Antaegumchultang, Kungsosan slightly increased revertivle colonies on any of the test strains under the conditions with S9 mix than under condition without S9 mix. These results indicate that most herbal medicines might be carefully used in obstetrics and gynecology, although they do not have the potent mutagenic potential under the present test conditions.
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