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임원봉,장유리아,김보선 한국키틴키토산학회 2023 한국키틴키토산학회지 Vol.28 No.2
In this study, we tried to examine the application of marine bioresource for bone graft materials. Bone is the skeletal structure that plays a physiologically pivotal role in the body. Various types of bone graft materials are being used to reconstruct the bone defect during dental and orthopedic surgery, and more optimized materials are being explored continuously. Bone graft materials derived from bioceramics are highly utilized in tissue engineering for bone regeneration, and generally provide hierarchical porosity, bioactivity and osteoconductive properties, and mechanical structures capable of 3D cell culture. These bone graft materials are generally based on porous calcium phosphate particles, which must maintain porosity once at the site of bone loss. However, despite routine use in traumatology and dental applications, biotransplantation requirements such as osteoinductivity and control of dissolution rates have not yet been met. Accordingly, bioceramic studies of marine-derived products are highly likely to become a new source of bone graft considering various marine materials that have not yet been fully identified. In this study, we tried to explore the application potential of major marine bioresources for bone tissue regeneration as bioceramics. In the present study, commercialized products and candidates in the preclinical research stage were reviewed, and major clinical requirements for the application of various available marine resources and the advantages and limitations of currently available bioresource were presented