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소아 아급성 괴사성 림프절염의 조기 진단을 위한 비특이적 경부 림프절 종대와의 감별
정은진 ( Eun Jin Chung ),권영희 ( Young Hee Kwon ),장여순 ( Yeo Sun Jang ),백혜성 ( Hey Sung Baek ),장기석 ( Ki Seok Jang ),박찬금 ( Chan Kum Park ),박정선 ( Jeong Seon Park ),오재원 ( Jae Won Oh ),이하백 ( Ha Baik Lee ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2011 소아알레르기 및 호흡기학회지 Vol.21 No.4
Purpose: We conducted this research to make an earlier diagnosis and identify better treatment for Kikuchi-Fujimoto disease (KFD) by comparing clinical findings with nonspecifically enlarged cervical lymph nodes in children. Methods: Nineteen patients were diagnosed with KFD by tissue pathology from a fine needle aspiration biopsy and/or excisional biopsy and were compared with the clinical, radiological, and pathological findings of reactive hyperplasia. Results: The average onset age of onset for patients with KFD was 11.8 ± 3.61 years, and the male to female ratio was 1:1.1, whereas patients with reactive hyperplasia were 11.8 ± 5.96 years, and the male to female ratio was 1.7:1. Patients with KFD suffered more from fever than patients with reactive hyperplasia (68% vs. 13%, P=0.002). Patients with KFD showed perinodal infiltration (P=0.001) and necrosis on computed tomography, whereas patients with reactive hyperplasia did not show any of these findings. Ultrasonographic findings were similar between the two study groups. In contrast, the histopathological examinations of biopsied cervical lymph nodes were enormously helpful for distinguishing the findings of KFD from those of patients with reactive hyperplasia. Conclusion: We recommend a histopathological examination to distinguish KFD from reactive hyperplasia in children with significantly enlarged cervical lymph nodes. (Pediatr Allergy Respir Dis(Korea) 2011;21:326-333)