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최영진 ( Young Jin Choi ),윤정민 ( Jung Min Yoon ),장여순 ( Yeo Soon Chang ),오재원 ( Jae-won Oh ) 대한천식알레르기학회(구 대한알레르기학회) 2017 Allergy Asthma & Respiratory Disease Vol.5 No.6
Purpose: The aim of this study was to evaluate hidden allergens of acute idiopathic urticaria (AIU) in childhood by using the component-resolved diagnostics (CRD). Methods: We applied CRD using pathogenesis-related protein family number 10 (PR-10) and nonspecific lipid transfer proteins (nsLTP). Results: Twenty-two of the 74 AIU children (29.7%) were found to be positive on CRD. Ten children were positive to nMal d 1 for apple (value range, 1.10-40.59), 6 to rConr a 1 for hazelnut (1.53-11.97), 4 to rPru p 1 for peach (1.32-11.83). 6 to rAra h 8 for peanut (1.20-8.12), 6 to nAct d 8 for kiwi (0.85-3.32), 4 to rBet v 1 for birch (2.49-54.28), and 3 to rAln g 1 for alder (2.32-5.74). Six children were positive to nPru p 3 for peach (1.45-18.77), 4 to rCor a 8 for hazelnut (2.56-9.19), 2 to nArt v 3 for mugwort (3.40-7.42), and 3 to rBet v2 to profilin of birch (2.56-17.46). Ten children with AIU were positive to multiple component proteins. For hazelnut, 5 children were positive to PR-10 (rConr a 1) and nsLTP (rConr a 1). For peach, 3 children were positive to PR-10 (rPru p 1) and nsLTP (nPru p 3). Conclusion: IgE sensitization to PR-10 or nsLTP may be allergen components for AIU in childhood. (Allergy Asthma Respir Dis 2017;5:331-335)