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- 저자 : 장순우 ( Jang Soonwoo ) (검색결과 4 건)
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천연 탄산 온천수의 아토피 유발 쥐 모델에 대한 혈소판 응집 억제 효능 평가
장순우,박정환,곽진영,고영미,안택원,Jang, Soonwoo,Park, Junghwan,Kwak, Jinyoung,Go, Youngmi,Ahn, Taekwon 대전대학교 한의학연구소 2017 혜화의학회지 Vol.26 No.1
Objectives:Spring water is widely known to relax muscles by promoting blood circulation. This study was conducted to analyze theantithrombotic effect of naturally carbonated hot spring water (NCHW) to assess its influence on blood circulation. Methods:Atopic dermatitis was induced in the skin of the mice used in this experiment. NCHW was applied, and the antithrombotic effect was assessed and compared with that of other interventions. The positive control group was treated orally with aspirin. Results:After 3 weeks of exposure to NCHW, the experimental groupshowed a significant antithrombotic effect. NCHW also produced inhibitory responses to both collagen- and ADP-induced platelet aggregation, whereas the group given aspirin reacted only to collagen-induced platelet aggregation. Conclusions:The experiment demonstrated the intrinsic antithrombotic effects of NCHW compared with those of artificially carbonated water, tap water, and aspirin. This result suggests the possibility that NCHW can be used as a supportive and alternative treatment for vascular diseases.
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고지방식이로 유도된 비만 생쥐모델에서 저령차전자탕의 항비만 효과
장순우,고영미,곽진영,안택원,Jang, SoonWoo,Kho, Young-mee,Kwak, Jin-young,Ahn, Taek-won 사상체질의학회 2018 사상체질의학회지 Vol.30 No.2
Objective This study investigated the effects of Jeoreongchajeonja-tang in a high-fat diet-induced obesity mouse model. Methods The study examined 9-week-old male mice (C57bl/6J) divided into four groups: the normal(C57bl/6J-Nr), control (high-fat diet only; HFD-CTL), positive-control (high-fat diet with Garcinia cambogia), and experimental (high-fat diet with Jeoreongchajeonja-tang; HFD-JCT) groups. After 7 weeks, the body weight, food efficiency ratio, organ weight, and visceral fat weight of the mice were measured. Blood serum tests, mRNA, liver histopathology, and epididymis adipocytes were also examined. Results Compared with the Control(HFD-CTL) group, the Experimental(HFD-JCT) group given Jeoreongchajeonja-tang showed significant reductions in absolute body weight and food efficiency ratio. The serum alanine aminotransferase, total-cholesterol, triglyceride, low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol, insulin-like growth factor-1, and leptin levels were significantly lower in the experimental group than in the control group. The serum adiponectin levels were significantly higher in the experimental group than in the control group. Compared with the control group, the experimental group showed significant reductions in absolute abdominal subcutaneous fat, epididymal adipose tissue, kidney adipose tissue, intestine adipose tissue, and liver, kidney and spleen adipose tissue weights. The C/EBP-${\beta}$, leptin, and SREBP1c/ADD1 mRNA expression were significantly lower in the experimental group than in the control group, while the UCP-2 and adiponectin mRNA expression were significantly higher. Compared with the control group, the experimental group showed a significant reduction in the absolute adipocyte area in the liver and epididymal adipose tissue. Conclusion Jeoreongchajeonja-tang has an anti-obesity effect. Additional clinical studies are expected.
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DNCB로 아토피가 유도된 NC/Nga생쥐에서 천연 탄산 온천수의 온도별 항아토피 효과
고가연 ( Go Gayeon ),박정환 ( Park Junghwan ),장순우 ( Jang Soonwoo ),김윤하 ( Kim Yoonha ),박정미 ( Park Jungmi ),안택원 ( Ahn Taekwon ) 대전대학교 한의학연구소 2016 혜화의학회지 Vol.25 No.1
Objectives : The aim of this study is to investigate the effect of natural carbonated hot spring water (NCHW) on DNCB-induced NC/Nga mice, an atopic dermatitis (AD) model. Methods :At first, NC/Nga mice were prepared and induced to have atopic lesion on their back skin by dinitrochlorobenzene (DNCB). They swam for 20 minutes everyday in tanks where the one is filled with 28℃ NCHW, the other is with 25℃ carbonated hot spring water and another is with artificial carbonated hot spring water (ACHW). After 3 weeks, We assessed the skin clinical score and macroscopic appearance, total IgE, IgG1 levels, WBC differential counting, IFN- γ, IL-4, IL-13, TNF-α production levels and histological changes. Results : There are meaningful results of improving atopic lesion-state by relieving the count of total IgE, IgG1 levels, WBC differential counting, IFN-γ, IL-4, IL-13, TNF-α production levels and recovering skin clinical score in the group with 28℃ NCHW in comparison with the other groups. Conclusions : The NCHW may have potential as an effective treatment for atopic dermatitis.
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비만 생쥐모델의 폐약(肺弱)을 유발하기 위한 Bleomycin의 농도 결정 연구.
고영미,장순우,안택원 大田大學校 附屬 韓方病院 2020 惠和醫學 Vol.29 No.1
Objectives : The objectives of this study is to develop a mouse model similar to Taeeum-type by inducing Lung fibrosis with bleomycin, and to determine adequate concentration of bleomycin. Methods : The subjects were divided into six groups: normal, obesity induced group, and bleomycin administered 0.015U, 0.03U, 0.06U, and 0.09U(U/100g bw) concentrations respectively. Each concentration of bleomycin was dissolved in distilled water, and administered through Intra-Nazal-Trachea injection method. Food intake and body weight were measured at regular time weekly. At the end of the experiment, blood was gathered by cardiac puncture for biochemical examinations, organs were removed for histological examinations, and weigh and mRNA genes was analyzed. Result : Mice administered with bleomycin at 0.015U and 0.03U showed body and fat weight gain, and increased blood total cholesterol, LDL-cholesterol, glucose, and free fatty acid level. Fat related genes also showed higher level than the control group. Obesity was most strongly induced in the mice administered with 0.03U of bleomycin. On the other hand, when bleomycin was administered at concentrations above 0.06U, a model of obesity mouse was not created due to rapid emphysema inflammation and weakness. Conclusions : Mice were most vulnerable to obesity when bleomycin was administered at a concentration of 0.3 to cause liver damage. Bleomycin concentration over 0.06U did not cause obesity-induced mice, due to severe damage in liver.
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