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신 청소율 검사(Renal Clearance Study)를 이용하여 진단한 Gitelman씨 증후군 2예
기주영 ( Gi Ju Yeong ),김혜영 ( Kim Hye Yeong ),임정묵 ( Im Jeong Mug ),오광식 ( O Gwang Sig ),박영선 ( Park Yeong Seon ),권순길 ( Kwon Sun Gil ),신종성 ( Sin Jong Seong ),김미성 ( Kim Mi Seong ),지정훈 ( Ji Jeong Hun ),엄재호 ( E 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.6
We have experienced two patients who had hypokalemic metabolic alkalosis as well as hypomagnesemia and hypocalciuria with elevated plasma renin activity. We have performed renal clearance study after water loading, administration of furosemide and thiazide in two patients and two normal controls. Maximal free water clearance per 100 mL glomerular filtration rate(C_(H2O) ) and distal fractional chloride reabsorption[ C_(H2O) /(C_(H2O) +C_(Cl))] in our patients were reduced than the controls. Chloride clearance(C_(Cl)) was increased after furosemide administration but not after thiazide administration. Distal fractional chloride reabsorption[C_(H2O) /(C_(H2O) +C_(Cl))] was dramatically decreased by furosemide administration in our patients, whereas thiazide had little effect on it. Fractional excretion of sodium, chloride, magnesium, calcium was increased by furosemide administration, whereas thiazide administration had little effect on this parameters. These findings suggested the presence of a defect in the distal convoluted tubule rather than in the thick ascending loop of Henle. Herein, we report two cases of Gitelman`s syndrome diagnosed by renal clearace study after water loading, administration of furosemide and thiazide.
채지영 ( Chae Ji Yeong ),기주영 ( Gi Ju Yeong ),김민옥 ( Kim Min Og ),유일영 ( Yu Il Yeong ),임정묵 ( Im Jeong Mug ),홍의실 ( Hong Ui Sil ),채희복 ( Chae Hui Bog ),박선미 ( Park Seon Mi ),윤세진 ( Yun Se Jin ) 대한소화기기능성질환·운동학회 2003 Journal of Neurogastroenterology and Motility (JNM Vol.9 No.2
목적: 간경변증은 원인과 관계없이 간 실질조직의 비가역적인 변화와 재생성 결절로 인한 전반적인 섬유화를 특징으로 하는 질병으로 오심, 구토, 트림, 식후 통증, 복부 팽만감 같은 상부위장관 증상들이 있다. 간경변증 환자에서 위배출장애가 관찰된다는 사실이 보고된 바 있으나, 피부 위전도에 대한 연구는 많지 않다. 본 연구에서는 간경변증 환자에서의 피부 위전도를 측정하여 정상인과 차이가 있는지 알아보고 간경변증 환자들 중 복수유무, 저알부민 혈증 여부에 따 Background/Aims: Liver cirrhosis (LC) is characterized by an irreversible change of liver parenchyme, irrespective of origin. It is characterized by esophageal varix bleeding, hepatic encephalopathy, ascites and upper gastrointestinal symptoms. Dysmotilit