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면역기능이 정상인 성인에서 발생한 Human Metapneumovirus 중증 폐렴
임효정 ( Hyo Jeong Lim ),이진우 ( Jin Woo Lee ),박영식 ( Young Sik Park ),김낙현 ( Nak Hyun Kim ),김문석 ( Moon Suk Kim ),임재준 ( Jae Joon Yim ),양석철 ( Seok Chul Yang ),유철규 ( Chul Gyu Yoo ),김영환 ( Young Whan Kim ),한성구 ( 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.67 No.2
Human metapneumovirus (hMPV) is a recently recognized human respiratory pathogen, which is known to be associated with upper and lower respiratory tract infections mainly in children, immunocompromised patients, and the elderly. The clinical manifestations of hMPV infections are similar to those of the human respiratory syncytial virus infection, which range from mild upper respiratory tract infection to severe bronchiolitis and pneumonia. Recently, hMPV has come to be thought of as the cause a similar spectrum of disease in adults as that seen in children; however, most of the reports of hMPV infections have focused on infection in children. We report a case of severe hMPV pneumonia requiring mechanical ventilation in an immunocompetent adult in Korea.
2차원 자화벡터를 이용한 퍼멀로이 박막의 이방성자기저항 해석
이영우(Young-woo Lee),호영강(Yongkang Hu),임재준(Jae-joon Lim),김철기(CheolGi Kim),김종오(Chong Oh Kim),윤대식(Tae Sick Yoon) 한국자기학회 2004 韓國磁氣學會誌 Vol.14 No.4
We measured in-plane 2 dimensional magnetization vector using two pick-up coil sets and investigate the relationship between magnetization vector and anisotropic magnetoresistance. We can determine magnetization vector by measuring magnetic moment in x and y direction simultaneously. As the uniaxial magnetic anisotropy of permalloy film increases, magnetoresistance approaches the expectation which is calculated from the angle between current vector and magnetization vector. Magnetoresistance ratio is linearly proportional to the y moment magnitude which is parallel to the current direction.
이진우 ( Jin Woo Lee ),박영식 ( Young Sik Park ),임효정 ( Hyo Jeong Lim ),곽민선 ( Min Sun Kwak ),임우현 ( Woo Hyun Lim ),임재준 ( Jae Joon Yim ),양석철 ( Seok Chul Yang ),유철규 ( Chul Gyu Yoo ),김영환 ( Young Whan Kim ),한성구 ( 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.67 No.4
Although tuberculosis is a chronic infectious disease that can occur in any section of the body, oral tuberculosis is rare. Here, we report a case of oral tuberculosis in which the patient sought treatment for a painful oral lesion. A histopathologic examination revealed the characteristics of tuberculosis and pulmonary lesions were detected on subsequent examination. The patient was treated with antituberculosis therapy, and his symptoms improved. This case emphasizes the importance of including oral tuberculosis as part of the differential diagnosis for mucosal lesions.
1차 항결핵제 약물이상반응 현황: 단일기관 약물이상사례 보고사례 기반 분석
김현화 ( Hyun Hwa Kim ),문미라 ( Mira Moon ),최나이 ( Nigh Choi ),강동윤 ( Dong Yoon Kang ),채경옥 ( Kyung Ok Chae ),이정실 ( Jungsil Lee ),임재준 ( Jae-joon Lim ),조상헌 ( Sang-heon Cho ),강혜련 ( Hye-ryun Kang ) 대한내과학회 2021 대한내과학회지 Vol.96 No.5
목적: 단일 상급종합병원에 보고된 1차 항결핵제의 약물이상반응 정보를 통해 한국인에서 항결핵제 약물이상반응 발생 현황을 파악하여 향후 결핵 관리를 위한 약물이상반응 대책 수립에 활용한다. 방법: 2009년부터 2018년까지 3차 의료기관에서 1차 항결핵제인 이소니아지드, 리팜핀, 에탐부톨, 피라진아미드를 처방 받은 환자들에 대해 원내 보고된 약물이상사례 데이터베이스를 기반으로 약물이상반응 정보를 수집하였고 약물이상반응이 발생한 환자의 나이, 성별, 총 치료 기간과 약물이상반응의 발생시점, 장기별 분류, 중증도 및 심각도 등을 분석하였다. 결과: 항결핵제를 처방 받은 5,482명 중 1,606명(29.3%)에서 약물이상반응이 보고되었고, 한 환자에서 1건에서 많게는 5건까지 총 2,098건의 약물이상반응이 보고되었는데, 경증이 680건(32.4%), 중등증이 1,282건(61.1%), 중증이 136건(6.5%)이었고 심각한 약물이상반응은 127건(6.1%)이었다. 1차 항결핵제에 의한 약물이상반응의 발생 장기별 분포는 피부 및 부속기관 장애가 27.5%로 가장 많았고, 위장관계 장애(17.5%)와 간 및 담도계 질환(13.1%)이 그 뒤를 이었다. 처방 건 당 이상반응 보고는 피라진아미드가 29.6%(1,406건/4,757명)로 가장 높았다. 중증 약물이상반응은 간 및 담도계 질환이, 심각한 약물이상반응의 경우 전신적 질환이 가장 많이 보고되었다. 총 치료 기간을 비교한 결과 약물이상반응이 발생하지 않았던 군은 224.0 ± 3.1일, 약물이상반응이 발생하였던 군은 247.0 ± 4.7일로 약물이상반응이 발생한 군이 통계적으로 유의하게 치료 기간이 평균 23일 정도 길었다(p = 0.009). 결론: 10년 동안 단일의료기관에서 수집된 1차 항결핵제의 약물이상반응 발생률은 29.3%였으며 중증반응도 6.5%로 적지 않게 발생하였다. 약물이상반응이 발생한 경우 치료 기간이 길어지거나 투약을 완료하지 못하는 경우가 생기는 등 치료의 진행에 영향을 미칠 수 있으므로 주의를 요한다. Background/Aims: Tuberculosis has incidence and mortality rates that are among the highest for all communicable diseases. Adverse drug reactions (ADRs) to anti-tubercular drugs are common, and have a major impact on treatment maintenance and prognosis. It is important to understand the characteristics of ADRs and establish a suitable management plan. Methods: We retrospectively reviewed patients with ADRs during treatment with first-line antitubercular drugs such as isoniazid, rifampicin, ethambutol, and pyrazinamide from 2009 to 2018. Age, sex, and total treatment period, and the onset, severity, seriousness, and system organ class of ADRs, were analyzed to understand the characteristics of first-line anti-tubercular drug-related ADRs. Results: A total of 1,606 of 5,482 patients (29.3%) experienced ADRs after administration of first-line anti-tubercular drugs. The incidence of ADRs related to isoniazid, rifampicin, ethambutol, and pyrazinamide was 22.2%, 21.3%, 24.5%, and 29.6%, respectively. A total of 2,098 ADR reports were made (mean of 1.3 ± 0.6 per patient). The rates of mild, moderate, and severe ADRs were 32.4%, 61.1%, and 6.5%, respectively. There were 127 reports (6.1%) of serious ADRs. Skin and appendage disorders were most frequently reported (27.5%), followed by gastrointestinal disorders (17.5%), and liver and biliary system disorders (13.1%). The total treatment period was longer in patients who experienced ADRs (224.0 ± 3.1 days vs. 247.0 ± 4.7 days, p = 0.009). Conclusions: The incidence of ADRs to first-line anti-tuberculosis drugs was 29.3%, and 6.5% were severe ADRS. ADRs prolonged the overall treatment duration, indicating the importance of their detection and management. (Korean J Med 2021;96:421-431)