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임두현,김지연,박주완,Lim, Doo-Hyun,Kim, Jee-Yeon,Park, Joo-Wan Korean Radioactive Waste Society 2011 방사성폐기물학회지 Vol.9 No.2
중저준위 방사성폐기물 처분장의 안전성 평가를 위하여 지하 사일로와 그 주변의 굴착손상영 역 (EDZ) 및 단열암반을 고려한 지하수유동해석과 핵종이동해석의 통합모델을 개발하였다. 사일로를 다중방벽개념으로 고려하여 사일로를 구성하는 3개의 특성지역 (waste, buffer, concrete)으로 구분하여 해석하였고, EDZ는 사일로 주변과 건설운영 터널 주변의 손상영역을 고려하였다. 단열암반의 불균일성은 분리단열 (discrete fractures)로 부터 해석된 불균일한 지하수 유속계로 도출하였고, 그 결과를 핵종의 이동경로를 모사하는데 사용하였다. 현 모델은 핵종누출에 따른 사일로 배치의 최적화와 안전성의 정량화를 도출하는데 사용가능하다. An integrated model for groundwater flow and radionuclide transport analyses is being developed incorporating six underground silos, an excavated damaged zone (EDZ), and fractured host rock. The model considers each silo as an engineered barrier system (EBS) consisting of a waste zone comprising waste packages and disposal container, a buffer zone, and a concrete lining zone. The EDZ is the disturbed zone adjacent to silos and construction & operation tunnels. The heterogeneity of the fractured rock is represented by a heterogeneous flow field, evaluated from discrete fractures in the fractured host rock. Radionuclide migration through the EBS in silos and the fractured host rock is simulated on the established heterogeneous flow field. The current model enables the optimization of silo design and the quantification of the safety margin in terms of radionuclide release.
PTPase의 작용에 menadione이 미치는 활성 기작
함승욱,박희중,임두현 中央大學校 基礎科學硏究所 1995 基礎科學硏究所 論文集 Vol.9 No.-
Vitamin K₃(menadione) has been shown to exhibit a broad range of antitumor activity in human cells as well as a phosphatase cofactor. It also imposed lower level of toxicity than other cancer chemotherapeutic drugs of quinone structure. Juan and Wu have recently demonstrated that the action of menadione is dose-dependent and cell cycle-specific. In this study, we have examined the effect of menadione in the action of cdc25 PTPase which is important of the control of cell cycle progression by the signal transduction pathway. Our mechanistic analysis with the model reaction has led to a new interpretation of the role of menadione. We also investigated that thiolate addition of cdc25 PTPase to menadione leads to directly to irreversible inhibition by covalent modification.