http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
임군일,권오진,김장희 대한정형외과학회 2014 Clinics in Orthopedic Surgery Vol.6 No.4
Background: The relationship between osteoarthritis (OA) and osteoporosis (OP) is complicated and it may differ according to the site or stage of disease. The purpose of this cross-sectional study is to examine the relationship between the severity of radiological knee OA and the degree of OP in the ipsilateral proximal femur as denoted by bone mineral density (BMD) in a Korean population, especially among women. Methods: One hundred ninety-five female patients who had knee pain and radiological knee OA were investigated with respect to the relationship of knee OA severity with BMD. The BMD of the proximal femur and spine was measured by dual energy X-ray absorptiometry, and the severity of knee OA was evaluated based on Kellgren-Lawrence (K-L) radiographic criteria, joint space narrowing (JSN) and mechanical axis of knee alignment. Partial correlation analysis and ANCOVA adjusted for confounding factors (age and body mass index) were performed to assess the relationship. Results: There was a statistically significant relationship between the BMD of the proximal femur and JSN, and the BMD of the proximal femur was positively associated with increased joint space width. There was a lack of association between the spine BMD and JSN. The BMD of the proximal femur was also significantly lower in patients who had a higher K-L grade. Conclusions: The radiographic finding of severe OA in the knee is associated with decreased BMD of the ipsilateral proximal femur including the femoral neck, trochanter, intertrochanter, and region of the entire hip (neck, trochanter, and Ward’s triangle).
The Concept of Early Osteoarthritis and Its Significance in Regenerative Medicine
임군일 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.3
Osteoarthritis (OA) has been investigated as one of important target diseases for regenerative medicine. The concept of early OA has recently emerged under the assumption that if OA is detected and intervened early, progression of OA might be arrested or delayed before irreversible destruction of the joint occurs. This concept also matters in regenerative medicine for OA because new regenerative technologies can work better when joint damage is minimal. Diagnostic criteria for early OA have been suggested in this background to find a group of patients who have a higher possibility of developing full-blown OA. However, as currently suggested criteria of early OA are mostly expert opinions lacking higher level of evidence, clinical validations are necessary to prove their value in patient care. While new treatment methods that can suppress or prevent symptoms at an early stage of OA before progressive and irreversible changes occur are being developed, detailed definition and classification of early OA agreed upon by major stakeholders in OA field and validated by prospective studies are necessary to prove the efficacy of these methods. As clinical outcome of regenerative treatment is related to patient characteristics and the status of the whole joint, it is of critical significance to predict which patient will progress and who will be responsive to regenerative treatment. While diagnostic criteria for early OA should be highly sensitive and applicable without employing biomarkers or magnetic resonance imaging, a subclassification and comprehensive endotyping /phenotyping using these techniques might be needed to detect the population who would be responsive to regenerative medicine.
일차 고관절 전치환술시 후방 도달법에 실시한 관절낭 봉합술
임군일(Gun Il Im),조원호(Won Ho Cho),김도영(Do Young Kim),신주호(Joo Ho Shin),김종훈(Jong Hun Kim) 대한고관절학회 1999 Hip and Pelvis Vol.11 No.1
We intended to analyze the effect of capsular repair after a posterior approach in primary total hip arthroplasty(THA). 43 hips of the capsulorrhaphy group were matched with 43 hips of capsulectomy group in age, sex, position of acetabular component, and in the use of elevated liners. The mean age of patients was 51.5 years in the capsulorrhaphy group and 51.4 years in the capsulectomy group. There were 30 male hips and 13 female hips in the capsulorrhaphy group and 33 male hips and 10 female hips in the capsulectomy group. The mean acetabular inclination was 46.1 degrees for the capsulorrhaphy group and 43.2 degrees for the capsulectomy group. The mean acetabular anteversion was 8.3 degrees for the capsulorrhaphy group and 7.9 degrees for the capsulectomy group. The preoperative diagnoses were osteonecrosis, femur neck fractures, or primary osteoarthritis in all of the hips. In the capsulorrhaphy group, the capsule was cleanly exposed and a T-shaped capsular incision was made and edges were tagged to facilitate repair. Tight capsulorrhaphy was performed after the main procedure. In the capsulectomy group, wide capsulectomy was made. External rotators were repaired in both groups. There was one dislocation in the capsulorraphy group which 6 dislocations in the capsulectomy group which occurred within 1 year after surgery. The difference was statistically significant(P<0.05). The results of this study suggest that capsulorrhaphy after a posterior approach can contribute to a reduction in the rate of dislocation.
임군일 ( Gun Il Im ) 한국조직공학과 재생의학회 2008 조직공학과 재생의학 Vol.5 No.4
관절연골과 연골하골을 모두 포함하는 골연골 결손은 관절의 역학적 불안정을 유발하여 결과적으로 퇴행성 골관절염을 초래한다. 최근 연골결손의 조직공학적인 치료가 가능하여져 현재 많은 전 임상 및 임상시도가 이루어지고 있다. 골연골 결손은 서로 성질이 다른 골 부분과 연골부분을 동시에 수복해야 하는 어려움이 있는데 현재 자가 골연골 이식술이 가장 많이 이용되고 있으나 정상적인 관절연골을 공여부로 이용해야 한다는 단점이 있다. 이 결손의 조직공학적 치유는 다공성 지지체에 세포를 3차원 배양하는 개념을 바탕으로 시도되고 있는데 본 총설에서는 조직공학적인 골연골 이식물의 개념과 골연골이식물의 재료, 세포원 및 세포훈련에 관한 최신지견을 정리하여 소개하고자 한다.
임군일 한국생체재료학회 2008 생체재료학회지 Vol.12 No.2
Wear particles generated from artificial joints cause biological reactions which usually lead to periprosthetic osteolysis. As the longevity of joint replacement is generally determined by the presence and progression of osteolysis, the strategy to prevent the complication is of utmost importance in joint replacement surgeries. Although macrophages are the main target of wear particles, bone forming cells and their progenitors are also directly affected by them. In this review, the results of investigations that have studied the effects of various particles on osteoblasts and menchymal stem cells are summarized.
인공관절 주위의 골용해: 마모입자에 대한 생물학적 반응
임군일 한국생체재료학회 2007 생체재료학회지 Vol.11 No.2
Although total hip arthroplasty is one of the most successful reconstructive procedure, periprosthetic osteolysis caused by the biological reaction to particulate wear debris poses the greatest challenge to the long-tem survival of the implanted prosthesis. In this review, the pathogenesis of and the pharmacological attempts to treat the biological reaction are outlined.