대상포진의 임상적 고찰과 Acyclovir 치료

이하린 ( Ha Rin Lee ),이민재 ( Min Jae Lee ),함정희 ( Jeong Hee Hahm ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.4

Background : Herpes zoster is an acute localized infection caused by varicella-zoster virus and characterized by unilateral pain and vesicular eruptions along the sensory dermatomes. Objective : The purpoe of this study was to elucidate the clinical features of herpes zoster and estimate the current theeap utic effect of Aeyclovir on herpes zoster. Method : We studied 517 cases of herpes zoster by retrospective method comparing annual incidence, age and monthly vacations, predilection site, associated conditions, complication and disease progress according toicylovir treatmentat at the department of dermatology, Ewha Womans University Hospital over 4 years(1990-1993). Results : 1. The average annual incidence during the 4 years was 0.2%, being on the increase recently. There was no significant, mannual, seasonal and monthly variation and the majority of cases occurred mast frequently were the fifth decade. 2. The dermatomal involvement of herpes zoster were most frequently on the thoracic dermatome (54.7%), followed by cervical, ophthalmic branch of trigeminal nerve, lumbar, sacral, maxillary branch of trigeminal nerve and mandibular branch of trigeminal nerve. The frequencies of associ ated conditions in herpcsioster, in descending order, were diabetes mellitus, hypertension, infectious disease, gastritis urgastric ulcer, malignant neoplasm, cardiovascular disease and postoperative condition. 3. The duration of treatment in herpes zoster was 3.8 weeks and significantly shortened in acyclovir-using group(p<0.05). The duration of treatment was significantly prolonged in associated disease (p <0.01). 4. Postherpetic neuralgil was the most common complication(11.2%), followed by ophthalmic complications, varicelliform erptions, secondary bacterial infections, meningoencephalitis, recurrent herpes zoster, keloid fomation, urinary retention, ptosis and hypopigmentation. Postherpetic neu ralgia increased with age and was observed most frequently in the ophthalmic branch of trigerninal nerve. Conclusion . The annwal incidence of herpes zoster shows a tendency to increase recently but there was no significant monthly or seasonal variation. The most common anatomical distribution was on the thoracic dematome. Herpes zoster was commonly associated with systemic disorders and the treatment durat,ion was prolonged in associated diseases. Acyclovir has a significant effect in shortening the treatment duration. Postherpetic neuralgia was the most common complication of herpes zoster and was observed most frequently in the ophthalmic branch of trigeminal nerve. (Kor J Dermatol 1995;33(4): 661-668)

다중지능 교수.학습 전략 기반 중학교 「기술.가정」 교과서 의생활 영역의 활동과제 분석

이하린(Lee, Ha Rin),심현섭(Shim, Huen Sup),채정현(Chae, Jung Hyun) 한국가정과교육학회 2021 한국가정과교육학회지 Vol.33 No.4

본 논문의 목적은 2015개정 교육과정의 중학교 ｢기술⋅가정｣ 교과서에서 의생활 영역의 활동 과제를 분석하여 개선점을제시하는 데 있다. 본 연구의 분석 대상은 12개 출판사의 ｢기술⋅가정 ①｣ 교과서 의생활 영역 본문의 활동 과제이다. 다중지능교수⋅학습 전략 분석 기준은 선행 연구를 참조하여 가정교과 전공 교수 1인과 의생활 전공 교수 1인에게 검토를 받고 연구자와협의 과정을 거쳐 재구성하였다. 이렇게 재구성한 분석 기준을 중심으로 12종 ｢기술⋅가정｣ 교과서의 의생활 영역 활동 과제를분석하였고 그 결과에 대해서는 전문가 11인에게 내용 타당도 검증을 받았다. 내용타당도 지수인 CVI는 0.94로 높게 나타났다. 다중지능 교수⋅학습 전략을 기반으로 ｢기술⋅가정｣ 교과서 의생활 영역의 활동 과제를 분석한 결과, 논리수학지능이 31.02%로가장 높은 비중을 차지하였다. 그 다음이 언어지능으로 23.81%, 시⋅공간지능이 17.08%, 자기이해지능이 14.71%, 대인관계지능이5.79%, 신체운동지능이 5.22%, 자연탐구지능이 2.37%, 그리고 음악지능이 0.00%의 순으로 나타냈다. 이 연구 결과에서 알 수있듯이, 의생활 영역에서 높은 비중을 차지 것은 논리수학지능, 언어지능, 시⋅공간지능, 자기이해지능과 관련된 교수⋅학습전략이었다. 한편 가정교과의 교수⋅학습 방법으로 권장되는 대인관계지능과 신체운동지능, 자연탐구지능과 관련된 교수⋅학습전략은 상대적으로 적은 비중을 차지하였으며 음악지능 교수⋅학습 전략은 전무하였다. 따라서 앞으로 ｢기술⋅가정｣ 교과서의생활 영역의 활동과제에는 논리수학이나 언어지능, 시⋅공간지능, 자기이해지능 교수⋅학습 전략 못지않게 대인관계, 신체운동, 자연탐구, 음악지능과 관련된 교수⋅학습 전략도 제시하는 것이 요구된다. The purpose of this study was to make suggestions for improvement by analyzing the activity tasks in the clothing life area in middle school ｢Technology & Home Economics｣ textbooks of the 2015 revised curriculum. For this purpose, the multiple intelligence teaching-learning strategy analysis criteria were reconstructed and used for analysis. The activity tasks of the clothing life area of ｢Technology & Home Economics I｣ textbooks from 12 different publishers were analyzed based on the reconstructed analysis criteria, and the content validity was verified by 11 experts. The content validity, assessed by CVI was 0.94. According to the results, the logical⋅mathematical intelligence accounted for the highest proportion with 31.02%, followed by linguistic intelligence(23.81%), visual/spatial intelligence(17.08%), intrapersonal intelligence(14.71%), interpersonal intelligence(5.79%), bodily/kinesthetic intelligence(5.22%), naturalistic intelligence(2.37%), and musical intelligence(0.00%). The results showed that the teaching-learning strategies most frequently implemented in clothing life area were logical/mathematical intelligence, linguistic intelligence, visual/spatial intelligence, and intrapersonal intelligence. On the other hand, teaching-learning strategies related to interpersonal intelligence, bodily/kinesthetic intelligence, and naturalistic intelligence were used at a relatively low proportion. Therefore, it is recommended to expand the teaching-learning strategies of interpersonal, bodily/kinesthetic, naturalistic and musical intelligence, for a more balanced intelligence development of students.

인공지능 이미지 인식 기술을 활용한 위험 알림 CCTV 서비스

이하린 ( Ha-rin Lee ),김유진 ( Yoo-jin Kim ),이민아 ( Min-ah Lee ),문재현 ( Jae-hyun Moon ) 한국정보처리학회 2020 한국정보처리학회 학술대회논문집 Vol.27 No.2

The number of single-person households is increasing every year, and there are also high concerns about the crime and safety of single-person households. In particular, crimes targeting women are increasing. Although home surveillance camera applications, which are mostly used by single-person households, only provide intrusion detection functions, this service utilizes AI image recognition technologies such as face recognition and object detection to provide theft, violence, stranger and intrusion detection. Users can receive security-related notifications, relieve their anxiety, and prevent crimes through this service.

백서 피부에서 약물대사 효소의 활성도와 유전자 발현에 미치는 All - trans - retinoic Acid의 영향

이하린 ( Ha Rin Lee ),함정희 ( Jeong Hee Hahm ),홍영숙 ( Young Sook Hong ) 대한피부과학회 1998 大韓皮膚科學會誌 Vol.36 No.1

Background : The activity of drug metabolizing enzymes and the modulation of their expression by inducers in the skin are the key factors for understanding of pharmacological and toxic effects of topically applied drugs. The role of these enzymes is of major importance, as they may contribute to determine the steady-state levels of biologically active substances. 3-Methylcholanthrene and all-trans- retinoic acid have been known to be inducers of the drug metabolizing enzymes. And all-trans- retinoic acid has many biological actions including anti-cancer effects. Objective: The purpose of this study was to evaluate the effect of all-trans-retinoic acid on inducing the expression and modulation of genetic polymorphism of drug metabolizing enzymes as well as to estimate the role of all-trans-retinoic acid in carcinogenesis and drug interactions. Methods : We analyzed the activities of CYP1A1(Cytochrome P450 1Al), NADPH cytochrome P450-reductase, UGT1 and GST after administration of 3-methylcholanthrene and all-trans-retinoic acid to the Sprague-Dawley male rats. We observed the inducible gene expression of CYP1A1, UGT1, GSTJt by RT-PCR and the genetic polymorphism of CYP1A1, UGT1, GSTK by PCR. Results . 1. The expression of CYP1A1, NADPH cytochrome P450-reductase, UGT1 and GST was induced by 3-methylcholanthrene and all-trans-retinoic acid. That of NADPH cytochrome P450-reductase and UGT1 is pronouncedly enhanced by all-trans- retinoic acid. 2. The effects of 3-methylcholanthrene and all-trans-retinoic acid on inducing the expression of CYP1A1 and UGT1 correlated with an increase of mRNA expression levels of CYP1A1 and UGT1. The modulation of mRNA expression levels of GST ㅠ was downregulated by all-trans-retinoic acid. 3. The genetic polymorphism of CYP1A1 was induced by 3-methylcholanthrene and all-trans- retinoic acid, and that of GSTM1 was not affected by the inducers. The induction of genetic polymorphism of GST ㅠ was down regulated by all-trans-retinoic acid. Conclusion: 3-Methylcholanthrene and all-trans-retinoic acid modulate the inducible expression and genetic polymorphism of drug metabolizing enzymes differentially. All-trans-retinoic acid can modulate the metabolism of procarcinogen such as 3-methylcholanthrene by inducing drug metabolizing enzymes. Furthermore, the elucidation of the molecular mechanisms underlying the regulation of drug metabolizing enzymes by 3-methylcholanthrene, all-trans-retinoic acid and other drugs could help to understand their respective roles in drug interactions and carcinogenesis. (Korean J Dermatol 1998;36(2) 193-203)

저농도 계면활성제로 유발되 자극성 접촉피부염에서 비침습적 측정방법을 이용한 피부 자극도 연구

이하린(Ha Rin Lee),최성호(Sung Woo Choi),김대호(Dai Ho Kim),김형옥(Hyung Ok Kim) 대한피부과학회 1999 대한피부과학회지 Vol.37 No.9

N/A Background : The bioengineering methods for investigating irritant skin reaction have been developed for several decades to evaluate the irritation potential more objectively and quantitatively and obtain the information which is not obvious by the visual examination. Objective : The purpose of this study was to compare the irritant skin reaction of three kinds of surfactants with various low concentrations which produce little reaction visually and investigative the threshold concentration that is reliable for a patch test. Also we investigated the sensitivity and the correlation between visual examination and bioengineering methods in four different concentrations of surfactants. Methods : Twenty healthy volunteers were patch tested with 0.01%, 0.05%, 0.1%, 1.0% of sodium laury1 sulfate(SLS), cety1 trimethy1 ammonium chloride(CETAC), POE(20) sorbitan monolaurate (Tween-20) on the flexor side of the Lt. forearm. The result of patch test was evaluated by visual scoring, evaporimeter, colorimeter, and corneometer until 72 hours. Results : 1. SLS, anionic surfactant, showed the highest irritation potential in visual scoring, TEWL, and skin color measurement. And CETAC, cationic surfactant, showed the greastest irritation in corneometer measurements than other surfactants. 2. TEWL was the most sensitive method for evaluation of skin irritation and correlated most closely with visual examination. 3. Concentration of surfactant higher than 0.1% showed to produce reliable and constant result of skin irritation as the experimental primary irritant. Conclusion : SLS is proved to be the most appropriate primary irritant for studying irritant contact dermatitis, and the degree and mode of skin irritation is different according to the concentration and kinds of surfactants. TEWL measurement is the most sensitive bioengineering method, which could detect early stages of irritation and correlate well with visual examination. (Korean J Dermatol 1999;37(9) : 1276∼1285)

비정형 멜라닌 세포 증식증에서 유래된 침습적 악성 흑생종

양정은(Jeung Eun Yang),이하린(Ha Rin Lee),김정원(Chung Won Kim),김태윤(Tae Yoon Kim) 대한피부과학회 1999 대한피부과학회지 Vol.37 No.10

N/A

식물 재배 환경 맞춤형 가정용 스마트 IoT 온실 개발

이세훈(Se-hoon Lee),이하린(Ha-Rin Lee),김한비(Han-Bi Kim) 한국컴퓨터정보학회 2022 한국컴퓨터정보학회 학술발표논문집 Vol.30 No.2

동복계통 자연유하식 도수터널 건설공사

임경호,양국정,박승균,이하린,Im, Gyeong-Ho,Yang, Guk-Jeong,Park, Seung-Gyun,Lee, Ha-Rin 한국터널지하공간학회 2011 자연, 터널 그리고 지하공간 Vol.13 No.4

Herpetic syringitis on the vulva associated with eccrine squamous syringometaplasia in malignant Lymphoma

채경옥 ( Kyung Ok Chae ),이하린 ( Ha Rin Lee ),최성우 ( Sung Woo Choi ),김태윤 ( Tae Yoon Kim ),김형옥 ( Hyung Ok Kim ) 대한피부과학회 1999 초록집 Vol.37 No.10

증례 : 신장 ; 리팜핀 유발성 ANCA 음성 반월상 사구체신염

이경남 ( Kyung Nam Lee ),송상헌 ( Sang Heon Song ),이하린 ( Ha Rin Rhee ),성은영 ( Eun Young Seong ),김일영 ( Il Young Kim ),이수봉 ( Soo Bong Lee ),곽임수 ( Ihm Soo Kwak ) 대한내과학회 2012 대한내과학회지 Vol.82 No.2

특이 병력이 없는 56세 남자가 폐결핵 치료 6주 후 전신부종과 신손상으로 왔고 신장 조직 검사를 통해 면역음성반월상 사구체신염으로 진단하였다. 폐결핵을 동반한 상태이므로 세포독성 약물은 사용하지 않았으며 약물 중단과 고용량 메칠프레드니솔론 치료를 통해 신기능 회복을 유도하였고, 리팜핀을 제외한 항결핵 약물로서 안정적으로 폐결핵을 치료할 수 있었다. A 56-year-old male with pulmonary tuberculosis was admitted to our hospital for evaluation of generalized edema. He began antituberculosis treatment with rifampin, isoniazid, ethambutol, and pyrazinamide. He experienced abnormal increments in weight and serum creatinine after 6 weeks. All serological findings, including anti-neutrophil cytoplasmic antibodies (ANCA), were negative. Rifampin was stopped because it might have caused the increase in creatinine. Renal biopsy was consistent with pauci-immune crescentic glomerulonephritis (CrGN). His renal function was improved by high-dose steroid treatment. Rifampin-induced, ANCA-negative pauci-immune CrGN is very rare; most cases of rifampin-induced acute renal failure are due to acute tubulointerstitial nephritis. We present here a case of rifampin-induced CrGN and pulmonary tuberculosis successfully treated with high-dose steroids and antituberculosis medications, excluding rifampin. (Korean J Med 2012;82:236-240)