http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Bevacizumab 사용 후 발생한 심한 허혈성 전대장염에서 대증적 요법으로 치료된
이하니 ( Ha Ni Lee ),이명아 ( Myung Ah Lee ),김상우 ( Sang Woo Kim ),임예지 ( Ye Jee Lim ),이화영 ( Hwa Young Lee ),이혜민 ( Hae Min Lee ),원혜성 ( Hye Sung Won ),전상훈 ( Sang Hoon Chun ) 대한소화기학회 2011 대한소화기학회지 Vol.58 No.1
Bevacizumab (Avastin(R)) is a monoclonal antibody against the vascular endothelial growth factor (VEGF) receptor that increases the overall survival rate when added to standard chemotherapy regimens in patients with metastatic colorectal cancer. The known toxicities of bevacizumab are hypertension, proteinuria, wound healing complications, arterial thrombosis, bleeding, and gastrointestinal complications. Especially ischemic colitis can rapidly develop into bowel perforation, so an emergency operation often is needed. Recently, a 65-year-old male patient developed ischemic pancolitis after FOLFOX (85 mg/m2 Oxaliplatin, d1; 200 mg/m2 Leucovorin, d1; 400 mg/m2 5-FU iv bolus, d1-2; and 600 mg/m2 5-FU, d1-2, every two wk) and Bevacizumab combination chemotherapy was administered. However, he recovered after early conservative care without surgery. We report this case with a review of literature. (Korean J Gastroenterol 2011;58:42-46)
Methotrexate 투여 중인 연소형 류마티스 관절염 환자에서 나타난 거짓막 대장염
유지한 ( Ji Han Yu ),김나영 ( Na Young Kim ),이혜민 ( Hae Min Lee ),이하니 ( Ha Ni Lee ),안효준 ( Hyo Jun Ahn ),김상우 ( Sang Woo Kim ),최규용 ( Kyu Yong Choi ) 대한소화기학회 2010 대한소화기학회지 Vol.56 No.6
Pseudomembranous colitis is mainly caused by antibiotics and Clostridium difficile infection. But conditions such as gastrointestinal surgery, antacid medication, anti-neoplastic agent or immunosuppressive agent which influences the normal flora of colon can induce colitis without the administration of any antibiotics. We experienced a 13 year-old male who was taking low-dose methotrexate for juvenile rheumatoid arthritis complained diarrhea and abdominal pain for 3 weeks. Sigmoidoscopic findings revealed diffuse patch yellowish pseudomembranes on the rectum. Histologic finding was compatible to pseudomembranous colitis. His symptom was improved after stop taking methotrexate and the administration of metronidazole. If a patient treated with immunosuppressive agents or antineoplastic agents complains diarrhea, fever or abdominal pain and has not improved with conservative care, pseudomembranous colitis should be taken into account as a differential diagnosis and prompt treatment is required for better prognosis. (Korean J Gastroenterol 2010;56:387-390)