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RISS 인기검색어
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- 저자 : 이태숙(Tae Shuk Lee) (검색결과 1 건)
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정문호(Moon Ho Chung),현명수(Myung Soo Hyun),이헌주(Heon Ju Lee),정문관(Moon Kwan Chung),심민철(Min Chul Shim),이태숙(Tae Shuk Lee) 대한내과학회 1988 대한내과학회지 Vol.34 No.5
N/A Pseudomembranous enterocolitis has been recognized since the 1880s as a severe intestinal lesion associated with a variety of conditions, In recent years, the majority of cases have been ascribed to antimicrobial treatment. Several studies have shown that C. difficle is the major cause of antibiotic associated pseudomembranous enterocolitis, Clinically, the disease is manifested by the diarrhea, abdominal pain, and fever. We wish to report our experience of 24cases of pseudomembranous enterocolitis associated with antibiotics, diagnosed by identifying characteristic yellow-white plaques, using with sigmoidoscopy that showed a pseudomembrane or summit lesion on a biopsy. The results were as follows: 1) There were 11 male and 13 female patients. Seventy-nine percent of the patients were over 50 years old at the time the diagnosis was made. 2) Various symptoms were assoicated with the onset of the disease, the most common being diarrhea (100%), abdominal pain (63%), and fever (54%). 3) Seventy-nine percent of patients developed diarrea within 15 days of antimicrobial chemotherapy. 4) Underlying medical illness were malignant tumor (21%), chronic renal failure (21%), colitis (12.5%), sepsis (8.3%), diabetes mellitus (8.3%), pneumonia (8.3%) and others. 5) Causes of antimicrobial therapy were prophylatic purpose (21%), pneumonia (21%), urinary tract infection (16.7%), enterocolitis (12.5%) and others. 6) Implicated antibiotics were ampicillin (45.8%), cephalosporin (29.1%), clindamycin (16.7%), penicillin (4.2%) and rifampin (4.2%) 7) Symptoms were improved with in 7 days, with medical agents such as vancomycin, metronidazole, lactobacillus, cholestyramine, and with only discontinuation of implicated antibiotics.
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