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실험적(實驗的) 당뇨병(糖尿病)에 대(對)한 옥천산(玉泉散) 및 파채자의 효과(效果)
이창근,Lee, Chang-Geun,Lee, Bong-Kyo 대한한방내과학회 1994 大韓韓方內科學會誌 Vol.15 No.2
In order to investigate the effects of Okchunsan (Sample A), Gamiokchunsan (Sample B) and Spinacia oleracea L. (semen: Sample C) on streptozotocin-induced diabetic rats, the experimal study was performed on the levels of glucose, insulin, total cholesterol, triglyceride, total protein, albumin, blood urea nitrogen (BUN), electrolytes $(Na^+,\;Ka^+,\;Cl^-)$, GOT and GPT in serum, hemoglobin, hematocrit, urine volume, glucose and protein in urine, body weight, liver and kidney weight. The results were obtained as follows: 1. Serum glucose levels were significantly decreased in Sample A. B and C group and serum insulin levels were increaseclin Sample A and B group. 2. Serum total cholesterol levels were recovered as the normal value in Sample A, B and C group and serum triglyceride levels were decreased in Sample A and C group. 3. Serum total protein levels were increased in Sample C group, BUN levels were decreased in Sample A and C group. 4. Serum $Na^+\;and\;Cl^-$ levels were increased, $K^+$ levels were decreased in Sample A, B and C group. 5. Serum GOT and GPT levels were remarkedly decreased in Sample A, B and C group. 6. Urine volume, urine glucose and protein levels were decreased in Sample A, B and C levles. 7. Body Weight showed a tendancy of increasing in Sample A, B and C group. 8. Levels of serum albumin, hemoglobin, nematocrit, liver and Kidney weight were not significantly changed. According to above results, Okchunsan, Gamiokchunsan and spinacia oleracea L. (Semen) were expected to be applied to the treatment of diabetes mellitus and its complications.
이창근,김익주,김신국,Lee, Chang-Geun,Kim, Ik-Joo,Kim, Sin-Guk 국립문화재연구소 1992 保存科學硏究 Vol.13 No.-
An Woljung wooden bridge structure, which assumde to has been built in the unification of shilla dynasty, was excavated at Nam-chun river basin inKyung-ju. As a result of primary investigation, the weigh loss was 70-80% and the volumetric shrinkage was up to 38% without any conservation. Between 1986 and1991, they were conserved by the two step PEG treatment at the Mokpo Conservation Institute for Maritime Archaeological Finds.
저췌(猪膵)를 가미한 세당환변방(世糖丸變方)이 Streptozotocin으로 유발된 흰쥐의 실험적 당뇨에 미치는 영향
이창근,소경순,정찬길,Lee, Chang-Geun,Soh, Kyeong-Sun,Jeong, Chan-Gil 대한약침학회 2007 Journal of pharmacopuncture Vol.10 No.3
Objectives We performed this study in order to investigate the effects of Sedang-Hwan(世糖丸) and modified Sedang-Hwan(世糖丸變方)on the diabetes mellitus. Methods We injected a vein with 65mg/kg of streptozotocin(STZ) on the rats. And then administered Sedang-Hwan(Sample 1 group); 18.7mg/kg/day, modified Sedang-Hwan; 16.5mg/kg/day(Sample 2 group) to Sample groups and observed the body weight, glucose and insulin levels. Results 1. The Sample 1, 2 groups showed a high suppressive effect of body weight loss compared to Control group. 2. The Sample 1, 2 groups’ glucose level showed a effective in lowering level compared to Control group. 3. The sample 1, 2 groups showed a higher insulin level than Control group. Conclusions Conclusively, modified Sedang-hwan was recognized to have decrease effect of serum glucose of the diabetic rats induced by streptozotocin. It is also required to study on the further detailed mechanism of decrease effect of serum glucose by modified Sedang-hwan.