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RISS 인기검색어
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- 저자 : 이증연 ( Jeung Yun Lee ) (검색결과 3 건)
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폐결핵환자의 폐환기기능 -제1편 폐결핵환자의 폐환기기능, 제2편 Bronchospirometry 를 이용한 좌우폐별 폐환기기능
김재원 ( Jae Won Kim ),정혜영 ( Hae Young Chung ),김광성 ( Kwang Sung Kim ),이증연 ( Jeung Yun Lee ),이정희 ( Jung Hee Lee ),오중근 ( Joong Keun Oh ),유회성 ( Hoe Sung Yoo ),오상백 ( Sang Baek Oh ) 대한결핵 및 호흡기학회 1973 Tuberculosis and Respiratory Diseases Vol.20 No.1
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마우스 장기에서의 Superoxide Dismutase의 분포
이증연,권년수,이희성 중앙대학교 의과대학 의과학연구소 1983 中央醫大誌 Vol.8 No.1
The subcelluar localization of superoxide dismutase(EC 1.15.1.1) was investigated in various organs of mouse. Mouse organs were fractionated into mitochondrial and cytosolic fractions by differential centrifugation. The activity of superoxide dismutase was measured by the method of McCord and Fridovich. The results were summarized as follows ; 1. Mouse organs contain two types of superoxide dismutase, one of which is localized in the mitochondria and the other was found in the cytosol. 2. Superoxide dismutase activity was found in all mouse organs investigated. Maximal activity of enzyme was observed in testicle, kidney and adrenal gland. 3. Most of superoxide dismutase activity was present in the cytosolic fraction(88~95%) , the rest being associated with mitochondria. 4. The cytosolic superoxide dismutase was found that contains copper and zinc and similar to the other cupro-zinc superoxide dismutase which was have been isolated from diverse eukaryotes. In contrast, the mitochondrial superoxide dismutase contains to be a manganoprotein. 5. The activity of cytosolic superoxide dismutase of testicle was most prominent in testicle than those of other tissues. And however, that of mitochondrial superoxide dismutase was highest in the adrenal gland. 6. The specific activity of superoxide dismutase in mitochondria was found about 5 fold greater than that of superoxide dismutase in cytosol. 7. 5mM cyanide inhibit the activity of cytosolic superoxide dismutase to 50~75%, but mitochondrial superoxide dismutase was inhibited to 9%.
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Diethyldithiocarbamate를 투여한 Rat 위점막의 장해와 Superoxide Dismutase에 관한 연구
이증연,백광진,이희성 중앙대학교 의과대학 의과학연구소 1988 中央醫大誌 Vol.13 No.2
An attempt was made to establish the effects of diethyldithiocarbamate(DDC) which is a copper and metalloenzyme irreversible inhibitor, on the activities of superoxide dismutase(SOD) and catalase in the gastric mucosa of rats. In addition microscopic study of gastric mucosa of rats treated with DDC, 1000mg/kg body weight was carried out. The activities of SOD were analysed by the methods described by McCord and Fridovich(1969) and Crapo et al.(1978), and the activities of catalse was assayed by the methods of Aebi(1983). The results were summarized as follows; 1. At 1 hr. after the administration of DDC, the homogenates of gastric mucosa of rats showed considerably lower activities of Mn-SOD, Cu, Zn-SOD and catalase when compared with those of the control rats (p<0.01). 2. Activities of Mn-SOD, Cu, Zn-SOD and catalase in the gastric mucosa increased sequentially at 1 hr., 3 hr., 7 hr. and 15 hr. after the administration of DDC (p<0.01) 3. Eventually at 7 hr. after the administration of DDC, the activities of Cu, Zn-S0D were similar to those of the control rats. At 3 hr., the activities of Mn-SOD and catalase were similar to the control rats. 4. At 15 hr. after the administration of DDC, the activities of Cu, Zu-SOD and Mn-SOD increased by approximately 2 times its control value, and the activities of catalase increased by approximately 4 times its control. 5. But at 15 hr. after the administration of DDC, the erosive gastritis was present in all of DDC treated rats. At 15 hr. after the administration of saline, the gastric mucosal Iesions of rats were absent. This study confirmed the development of erosive gastritis in rats following the administration of DDC, an copper and metalloenzyme irreversible inhibitor. Therefore superoxide radicals may play an important role in the pathogenesis of gastric mucosal lesion. These results indicate that SOD may be one of the factors in the gastric mucosal defence machanism.
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