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유체전단응력에 의하여 3T3-L1 지방세포가 받는 영향
이정근,이영훈,진희원,이서현,김지현,Lee, Jeongkun,Lee, Yeong Hun,Jin, Heewon,Lee, Seohyun,Kim, Chi Hyun 대한의용생체공학회 2018 의공학회지 Vol.39 No.4
Adipocytes affect obesity through the regulation of lipid metabolism. Physical loading is an important regulator of fat tissue. There are ongoing in vitro studies inducing mechanotransduction on 3T3-L1 preadipocytes with mechanical stimulus in order to treat obesity by inhibiting adipogenesis and provoking cell death. In this study, our goal was to suggest a new therapy for obesity by investigating whether fluid shear stress (FSS) changes transcription factors on 3T3-L1 related with adipogenesis and cell death. FSS loading was applied to 3T3-L1 preadipocytes at 1Pa and 1Hz. After loading, bright field images were taken and an immunofluorescence assay was conducted to observe actin stress fiber formation. Western blot analysis was conducted to identify the activation of the ERK pathway as well as the adipogenic factors, which including C/EBPs and $PPAR{\gamma}$. The expression of osteopontin, a protein related to inflammation in adipose tissue, and cell death related factors, Bax, Bcl-2, and Beclin, were also measured. Results showed that FSS stimulated the formation of actin stress fibers in 3T3-L1 and also that the activation of C/EBPs decreased significantly when compared with the control group. $PPAR{\gamma}$ activation in the 2 hour FSS group was lower than the 1 hour FSS group, which implied that the results were time dependent. Additionally, there were no differences in the expression of cell death factors after FSS loading. In summary, similar to other fibroblasts, the formation of actin stress fibers induced by mechanotransduction may affect the differentiation of 3T3-L1, leading to inhibition of adipogenesis and inflammation.
Improving RFID Anti-Collision Algorithms with Multi-Packet Reception
이정근,권태경,최양희,김경아,Lee, Jeong-Keun,Kwon, Taek-Young,Choi, Yang-Hee,Kim, Kyung-Ah The Korean Institute of Communications and Informa 2006 韓國通信學會論文誌 Vol.31 No.11A
One of the important performance issues in large-scale RFID systems is to resolve collisions among responses from RFID tags. Considering two do facto anti-collision solutions, namely the binary-tree splitting algorithm and the Slotted-Aloha algorithm, we propose to use multi-packet reception (MPR) capability to enhance the RFID tag reading rate (i.e., throughput). MPR allows an RFID reader to receive multiple reponses transmitted by tags at the same time. We analyze the effect of MPR capability in the above anti-collision algorithms, which is also validated by simulation. The analysis and simulation results show that RFID reader antenna design and signal separation techniques play an important role in improving RFID system performance with MPR capability. 다수의 MD 태그들로부터 발신된 메시지들 사이의 충돌을 빠르게 해소하는 일은 대규모 RFID 시스템의 성능을 결정짓는 중요한 문제이다. 본 논문에서는 충돌방지 (anti-collision) 알고리즘의 성능 향상을 위하여 다중 패킷 수신 (multi-packet reception) 기법을 사용할 것을 제안한다. 다중 패킷 수신 기법을 통해서 RFID 판독기는 동시에 전송된 다수의 태그를 충돌없이 수신 할 수 있다. 대표적인 충돌방지기법인 이진 트리 분리 (binary-tree-splitting) 알고리즘과 슬롯 알로하 (Slotted-Aloha) 알고리즘에 다중 패킷 수신 기법을 적용했을 경우의 성능향상을 분석하는 모델을 제안하고 제안된 분석모델의 정확성을 시뮬레이션을 통해서 비교 검증한다. 다중 패킷 수신기법 적용 시 큰 폭의 성능향상이 있음을 보이고, 다중 패킷 수신 기법의 이득을 최대화하기 위해서는 RFID 판독기 안테나 디자인과 수신 신호 분리 기술이 중요함을 보인다.
텅스텐-15% 카파 사출성형체의 잔류 탄소량 분석에 대한 측정 불확도
이정근,Lee, Jeong-Keun 한국분말야금학회 2007 한국분말재료학회지 (KPMI) Vol.14 No.6
Carbon contamination from the binder resin is an inherent problem with the metal powder injection molding process. Residual carbon in the W-Cu compacts has a strong impact on the thermal and electric properties. In this study, uncertainty was quantified to evaluate determination of carbon in a W-15%Cu MIM body by the combustition method. For a valid generalization about this evaluation, uncertainty scheme applied even to the repeatability as well as the uncertainty sources of each analyse step and quality appraisal sources. As a result, the concentration of carbon in the W-Cu part were measured as 0.062% with expanded uncertainty of 0.003% at 95% level. This evaluation example may be useful to uncertainty evaluation for other MIM products.
탄화 티타늄 금속기 복합재의 드릴가공 특성에 대한 경험적 고찰(1)
이정근,Lee, Jeong-Keun 한국분말야금학회 2006 한국분말재료학회지 (KPMI) Vol.13 No.6
The experimental data from the central composite design runs were utilized for mathematical models far the drilling characteristics containing linear, quadratic and interactive effects of the parameters such as volume fraction of TiC in the composites, drill speed, feed rate and drill diameter. The models were developed via stepwise selection where the insignificant effects were removed using t-test. The models were subjected to optimization of maximizing drill life and satisfying the other constraints.
이정근,Lee, Jeong-Keun 한국분말야금학회 2006 한국분말재료학회지 (KPMI) Vol.13 No.6
Wear of steel plate was measured during unlubricated sliding against TiC composites. These composites consist of round TiC grains and steel matrix. TiC grain itself exhibits low surface roughness and round shape, which does not bring its counterpart into severe damage from friction. In our work a classical experimental design was applied to find out a dominant factor in counterpart wear. The analysis of the data showed that only the applied load has a significant effect on the counterpart wear. Wear rate of counterpart increased non-linearly with applied load. Amount of wear was discrepant from expectation of being in proportion to the load by analogy with friction force. Our experimental result from treating matrix variously revealed bimodal wear behavior between the composites and counterpart where a mode seems to result from the special lubricant characteristic of TiC grains, and the other is caused by metal-to-metal contact. The two wear mechanisms were discussed.