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진구수침에크스, 지실수침(枳實水浸)에크스, 및 진구성분(??成分)Lycaconitine의 산양(山羊)진드기 구제효력(驅除效力)에 관한 야외실험(野外實驗)
이장락,Lee, Jang-Nag 대한수의학회 1962 大韓獸醫學會誌 Vol.2 No.2
It was previously reported that aqueous extracts of Radix Jingyu and Fructus ponciri, and also Lycaconitine, an alkaloid of Radix Jingyu, exhibit excellent effects as cattle tick repellent. The repost deals with the field teats carried out with these three drugs for their repellent effects against Korean goat ticks, nearly 99 per cent of which are composed of Haemaphysalis bispinosum and the rest of Boophilus microplus. The study revealed that Korean goat ticks are as susceptible to all three drugs tested as korean cattle ticks.
진구성분 Lycaconitine의 약리작용(藥理作用)에 관한 연구(硏究)
이장락,Lee, Jang-Nag 대한수의학회 1962 大韓獸醫學會誌 Vol.2 No.2
Although Lycaconitine, one of the alkaloids of Radix Jingyu, had been identified in 1884, its use in practice has not been known probably because of our limited knowledge on pharmacologic actions of the drug. Recently repellent efficacy of Lycaconitine against Korean cattle ticks and goat ticks was demonstrated. Obviously, there in a need to investigate toxicologic aspects of Lycaconitine before its widespread use for the control of animal ticks can be attempted. As will be reported in this paper, Lycaconitine Shows a wide margin of safety in the concentration applied as cattle or goat tick repellent.
유당 카세인 및 요소의 경구투여용 누에병 치료약 부형제로서의 응용 가능성에 관한 연구(제 1 보)
이장락 한국잠사학회 1973 한국잠사곤충학회지 Vol.15 No.2
앞으로 경구투여용 누에병 치료약이 개발될 가능성이 충분히 있는바 이러한 약물의 임상적 적용에 있어서는 투약의 편의와 정확을 위해서 적당한 부형제를 사용하지 않을 수 없다. 본인은 유당 카세인 및 요소를 경구투여용 누에병 치료약의 부형제로서 쓸수 있을 것임을 추정하고 1973년 춘잠기에 서울대 농대 잠실에서 일련의 실험을 실시한 결과 투여량과 투여 회수를 적당히 선정할 때는 유당, 카세인, 및 요소는 모두 누에의 발육과 고치만들기에 별반의 영향을 미치는 일 없이 경구투여용 누에병 치료약의 부형제로서 유용하게 쓸수 있을 것임을 알아내었기에 이에 실험과정과 실험 성적을 보고한다.
진구성분의 소진드기 구제(驅除)(살충(殺蟲) 및 기피(忌避))효과(效力)에 관한 연구(硏究)
이장락,Lee, Jang-Nag 대한수의학회 1962 大韓獸醫學會誌 Vol.2 No.2
In the previous report it was demonstrated that aqueous extracts of two Korean indigenous crude drugs, Radix Jingyu and Fructus ponciri, have an excellent tick repellent effect, and also the need for further analytical study of these crude drugs was suggested. In the experiments to be reported herein, attempts were made to find out the active ingredients from Radix Jingyu, since the aqueons extract of Radix Jingyu proved to be mone effective than that of Fructus ponciri. It will be shown that the active ingredient is indicative of Lycaconitine, a known alkaloid. An aqueons solution containing 1.5 Gms of Lycaconitine in tartrate when sprayed on a cow exerted tick repellent effect against Boophilus microplus which lasted approximately 25 days without any harmful influences on cattle. It will also be shown that the oil-fat components of Radix Jingyu act synergistically with Lycaconitine in accelerating and lengthening the effect, although the components alone have no effect under the conditions tested. It was of interest to note that the oil-fat components of Radix Jingyu showed definite repellent effect against the larvae of Boophilus microplus in laboratory experiments by the method newly devised. On the basis of these observations, it was concluded that Lycaconitine can be used as cattle tick repellent, and the evidence seems to warrant a large scale production of Lycaconitine for its widespread use. Further studies on the possible effect of the alkaloid on other genera or species of ticks and related vermins were also indicated.