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이용희 ( Yunghee Lee ),조영재 ( Young-jae Cho ) 대한내과학회 2019 대한내과학회지 Vol.94 No.6
Diagnosis and treatment criteria were recently updated based on the Sepsis-3 guidelines, which recommend the sequential organ failure assessment for accurate characterization of organ dysfunction. Large randomized controlled trials have found neutral results with early goal-directed therapy. To improve outcomes, treatment bundles incorporating standards for early sepsis treatment, in-cluding antibiotic and steroid treatment, were developed. Thus, future research should address the effects of steroids and im-mune- modulating agents on refractory septic shock as well as the development of new coagulopathy therapies and dynamic as-sessment tools. (Korean J Med 2019;94:495-499)