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      • SCOPUSKCI등재

        SS330 용접재에서 재분포 잔류응력 및 균열닫힘영향을 고려한 파로거동에 관한 연구

        이용복,정진성,조남익,Lee, Yong-Bok,Jeong, Jin-Seong,Jo, Nam-Ik 대한기계학회 1996 大韓機械學會論文集A Vol.20 No.7

        In this study residual stress in weldment was considered about the effect on the fatigue propagation and about the effect of redistribution of residual stress. Then, fatigue tests were conducted by the center notched specimens machined with welded plate. The residual stress and its redistribution after the crack growth were measured by the magnetizing stress indicator and hole-drilling method. Fatigue crack propagation was estimated by the specimens having residual stress redistributed after the cracks growth and having the effects of crack closure. Crack growth rates were predicted and compared with experimental results. It had been found that the predicted crack propagation rates have a good agreement with experimental results when the redistribution of residual stress was considerd.

      • KCI등재

        압연 및 용접방향이 같은 맞대기 용접강판의 하중방향에 따른 피로균열 진전특성

        이용복,김성엽,오병덕,Lee Yong-Bok,Kim Sung-Yeup,Oh Byung-Duck 대한용접접합학회 2005 대한용접·접합학회지 Vol.23 No.6

        Most of the welding steel plate structures have complicated mechanical problems such as rolling directional characteristics and residual stresses caused by manufacturing process. For the enhancement of reliability and safety in those structures, therefore, a systematic investigation is required. SS400 steel plate used for common structures was selected and welded by FCAW butt-welding process for this study, and then it was studied experimently about characteristics of fatigue crack propagations with respect to rolling direction and welding residual stress of welded steel plates. When the angles between rolling direction and tensile loading direction in base material are increased, their ultimate strength not show a significant difference, but yielding strength are increased and elongations are decreased uniformly. It is also shown that fatigue crack growth rate can be increased from those results. When the angles between welding bead direction and loading direction in welded material are increase, fatigue crack growth rate of them are decreased and influenced uniformly according to the conditions of residual stress distribution. In these results, it is shown that the welded steel plate structures are needed to harmonize distributed welding residual stress, rolling direction and loading direction fur the improvement of safety and endurance in manufacture of their structures.

      • SCOPUSKCI등재

        랫트에 있어서 페노바르비탈 전처리가 딜티아젬의 생체내 동태에 미치는 영향

        이용복,고익배,이민화,Lee, Yong-Bok,Koh, Ik-Bae,Lee, Min-Hwa 한국약제학회 1992 Journal of Pharmaceutical Investigation Vol.22 No.3

        The influence of phenobarbital (PB) pretreatment (75 mg/kg/day, i.p. for 4 days) on the pharmacokinetics of diltiazem (DTZ) and its metabolite, desacetyldiltiazem (DAD), was investigated in rats. DTZ was injected via femoral (3 mg/kg) or portal (10 mg/kg) vein to the control and PB-pretreated rats. DAD was also injected separately via femoral (3 mg/kg) vein to both groups of rats. The intrinsic hepatic plasma clearance of DTZ was found to be significantly increased (6.8-fold) by the PB pretreatment. However, the fraction of an intravenous DTZ dose converted to DAD $(F_mi)$ was only slightly (6%) increased and calculated metabolic rate constant of DTZ to DAD was not affected by the pretreatment. On the other hand, plasma free fraction of DTZ was increased (1.8-fold) from $4.24{\pm}0.25%$ to $7.45{\pm}0.54%$ by the pretreatment. However, the l.8-fold increase in the free fraction of DTZ would not explain the 6.8-fold increase in the hepatic intrinsic clearance of DTZ. Therefore, the increase in either the hepatic blood flow or the metabolism other than to DAD was expected as the probable mechanism(s) of the increased hepatic clearance of DTZ. Sequential metabolism of DAD to further metabolites, however, would be a more potential cause of the apparently unchanged metabolism of DTZ to DAD by the PB-pretreatment.

      • SCOPUSKCI등재

        유제화에 의한 경구용 항암제인 테가푸르의 장관 임파수송

        이용복,남권호,장우익,오인준,고익배,Lee, Yong-Bok,Nam, Kweon-Ho,Chang, Woo-Ik,Oh, In-Joon,Koh, Ik-Bae 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.1

        W/O and O/W emulsions of tegafur (50 mg/5 ml/kg) were orally administered to rats to compare with their mesenteric lymphatic delivery effects. And also in order to demonstrate the lymph targeting associated to the oral route, it was deemed necessary to investigate the fate of solution after oral administration as a control. Lymph and plasma samples were periodically taken from each subject of mesenteric lymphatic duct cannulated rats. Then, lymph and plasma levels of tegafur and its active metabolite, 5-FU, were simultaneously observed. Also pharmacokinetic parameters were compared with each others. On the other hand, most previous studies of lymphatic transport have not addressed the question of whether an increase in mesenteric or thoracic lymph transport by the manipulation of a suspected variable was due to a selective delivery to the intestinal lymphatics or an overall increase availability. Therefore, based on a physiologically based pharmacokinetic model which represents the characteristics of lymphatic systems, we are also going to determine the contributions of mesenteric lymph transport versus thoracic lymph transport of tegafur reported in reference(13). In comparison with tegafur solution, AUC and mean residence time of plasma tegafur were significantly increased in W/O emulsion but significantly decreased in O/W emulsion. Lymph flow rates were similar in both solution and W/O emulsion but half in O/W emulsion. AUC of tegafur in mesenteric lymph and in plasma for W/O emulsion were 3.7 times and 2.9 times more than those for O/W emulsion, respectively. And AUC of 5-FU in thoracic lymph for W/O emulsion was 3.7 times more than that for O/W emulsion. These results suggested that lymphatic delivery or tegafur by W/O emulsion was more effective than that by on emulsion due to its differences or formation ability of chylomicrons.

      • KCI등재

        시메티딘이 간혈류량에 미치는 영향 - Rat에 있어서 Indocyanine Green의 체내 동태를 중심으로 -

        이용복,고익배,Lee, Yong-Bok,Koh, Ik-Bae 한국임상약학회 1993 한국임상약학회지 Vol.3 No.2

        The influence of cimetidine pretreatment(100mg/kg, single i.p.) on the hepatic blood flow was investigated using pharmacokinetic parameters of indocyanine green(ICG) in the rat on the basis of hepacc perfusion-limited model. ICG(1mg/kg) was respectively administered via femoral and portal vein to the control and to the cimetidine-pretreated rats. The rate constant K12, K20 and the systemic clearance(CLt) of ICG were significantly(p<0.05) decreased ill the cimetidine-pretrea-to(B rats, but no significant diffirences were observed in hematocrit and liver weight. The biliary excretion rates of ICG were also decreased regardless of the route of administration in the cimetidine-pretreated rats. And also the hepatic blood flow in rats was decreased about $16\%$ by cimetidine. It may be concluded that the decreased hepatic blood flow with cimetidine mainly contributed to the decreased hepatic uptake and the decreased systemic clearance of ICG.

      • SCOPUSKCI등재

        나프록센의 비선형 체내동태에 미치는 페노바르비탈의 영향

        이용복,채명애,고익배 ( Yong Bok Lee,Myung Ae Chae,Ik Bae Koh ) 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.2

        N/A In order to elucidate the effect of phenobarbital (PB) on the nonlinear pharmacokinetic behavior of naproxen (NAP), we compared the dose dependent hepatic intrinsic clearance, biliary excretion and protein binding of NAP in control rats to those in the PB-pretreated rats which were intraperitoneally pretreated with PB sodium (75 ㎎/㎏) once a day for four days. NAP was injected via femoral (1.5 ㎎/㎏) and portal(0.25, 0.5, 1.5, 15 and 30 ㎎/㎏) vein to the control and PB-pretreated rats, respectively. And also. we measured the plasma free fraction of NAP with the equilibrium dialysis method and the biliary excreted total amounts of NAP in both rats. Plasma free fraction of NAP was decreased in lower concentration than 150 ㎍/㎖ of NAP due to PB pretreatment. In higher concentration, however, plasma free fraction was increased. These in vitro results suggest that the total protein concentration was increased but the total binding capacity of NAP to protein was decreased by PB-pretreatment. The total plasma clearance and the hepatic intrinsic clearance of NAP had similar values in both groups, respectively. And, both clearances of NAP were significantly increased by PB-pretreatment. Even though the plasma free fractions of NAP in both groups were constantly remained within the concentration range according to the increase of administration dose, the hepatic intrinsic clearances of NAP were significantly increased in both groups with the increased dose. And, the biliary excreted total amounts of NAP were significantly increased by PB-pretreatment at the lower dose, but decreased at the higher dose. These in vivo results suggest that NAP represents the uncommon nonlinear pharmacokinetic behavior that the hepatic intrinsic clearance was enhanced with the increased dose, and that PB enhances further the hepatic intrinsic clearance of NAP with the increased dose due to its enzyme induction effect.

      • KCI등재
      • KCI등재

        십자형 필릿 용접부에서 재료 두께 및 용접 층수에 따른 피로파괴 특성

        이용복,Lee, Yong-Bok 대한용접접합학회 2010 대한용접·접합학회지 Vol.28 No.6

        Most of joining processes for machine and steel structure are performed by butt and fillet welding. The mechanical properties and fatigue strength of their welding zone can be effected largely by the differential of generated heat and changes of grain size according to thickness of material and number of passes in welding process. In this study, it was investigated about characteristics of fatigue failure according to thickness of material and number of passes in cruciform fillet weld zone as the basic study for safe and economic design of welding structures. Fracture modes in cruciform fillet weld zone are classified into toe failure and root failure according to non-penetrated depth. It can be accomplished economic design of welding structures considering fatigue strength when the penetrated depth in fillet weld zone is controled properly.

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