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십자형 필릿 용접부에서 재료 두께 및 용접 층수에 따른 피로파괴 특성
이용복,Lee, Yong-Bok 대한용접접합학회 2010 대한용접·접합학회지 Vol.28 No.6
Most of joining processes for machine and steel structure are performed by butt and fillet welding. The mechanical properties and fatigue strength of their welding zone can be effected largely by the differential of generated heat and changes of grain size according to thickness of material and number of passes in welding process. In this study, it was investigated about characteristics of fatigue failure according to thickness of material and number of passes in cruciform fillet weld zone as the basic study for safe and economic design of welding structures. Fracture modes in cruciform fillet weld zone are classified into toe failure and root failure according to non-penetrated depth. It can be accomplished economic design of welding structures considering fatigue strength when the penetrated depth in fillet weld zone is controled properly.
시메티딘이 간혈류량에 미치는 영향 - Rat에 있어서 Indocyanine Green의 체내 동태를 중심으로 -
이용복,고익배,Lee, Yong-Bok,Koh, Ik-Bae 한국임상약학회 1993 한국임상약학회지 Vol.3 No.2
The influence of cimetidine pretreatment(100mg/kg, single i.p.) on the hepatic blood flow was investigated using pharmacokinetic parameters of indocyanine green(ICG) in the rat on the basis of hepacc perfusion-limited model. ICG(1mg/kg) was respectively administered via femoral and portal vein to the control and to the cimetidine-pretreated rats. The rate constant K12, K20 and the systemic clearance(CLt) of ICG were significantly(p<0.05) decreased ill the cimetidine-pretrea-to(B rats, but no significant diffirences were observed in hematocrit and liver weight. The biliary excretion rates of ICG were also decreased regardless of the route of administration in the cimetidine-pretreated rats. And also the hepatic blood flow in rats was decreased about $16\%$ by cimetidine. It may be concluded that the decreased hepatic blood flow with cimetidine mainly contributed to the decreased hepatic uptake and the decreased systemic clearance of ICG.
흰쥐 분리 간세포에 있어서 딜티아젬의 간클리어런스에 미치는 페노바르비탈의 영향
이용복,오준교,고익배,Lee, Yong-Bok,Oh, Joon-Kyo,Kho, Ik-Bae 한국약제학회 1996 Journal of Pharmaceutical Investigation Vol.26 No.1
In order to study the effect of phenobarbital(PB) on the hepatic transport of diltiazem(DTZ), $Ca^{2+}$ channel blocker, we used isolated hepatocytes of rat which was intraperitoneally pretreated with phenobarbital sodium(75 mg/kg) for four days once a day. For the isolation of rat liver cells, a modification of the two step procedure of Seglen was used. DTZ was dissolved in incubation buffer to the final DTZ concentrations of 200, 400, 600, 800 and 1000 ng/ml in order to elucidate the uptake characteristics of DTZ by hepatocytes. Reactions were stopped at 10, 20, 30, 45, 60, 90, 120 and 300 sec. The initial velocity was determined by disappearance of diltiazem in the hepatocyte suspension. On the other hand, to determine the effect of PB on the in vitro hepatic intrinsic clearance of DTZ we obtained the metabolism rates of DTZ in the control and the PB-pretreated rat hepatocyte at various time intervals. According to pretreatment with PB, the size of hepatocyte and the amount of protein per $10^6$ cells were significantly (p<0.01) increased from $26.92{\pm}0.1364\;m$ to $35.31{\pm}1.00\;m$ and from $468{\pm}6.5\;{\mu}g/10^6$ cells to $628.8{\pm}12.1{\mu}g/10^6$ cells, respectively. In the case or hepatic uptake of diltiazem, $K_m$ was not different in the normalization by cell numbers and increased from $2.90\;{\mu}M\;to\;13.89\;{\mu}M$ in the normalization by protein amount. $V_max$ was increased regardless of normalization by protein amount and cell numbers, from $1.21\;{\mu}mole/min \;{\cdot}\;mg\;protein\;to\;3.96\;{\mu}mole/min\;{\cdot}\;mg\;protein\;and\;from\;2.38\;{\mu}mole/min\;{\cdot}\;10^6\;cells\;to\;2.83\;{\mu}mole/min\;{\cdot}\;10^6\;cells$, respectively. The in vitro hepatic intrinsic clearance of DTZ was significantly (p<0.01) increased from $0.640{\pm}0.038\;ml/mim\;{\cdot}\;10^6\;cells\;to\;2.385{\pm}0.212\;ml/min\;{\cdot}\;10^6\;cells$ due to PB-pretreatment. These results suggest that the uptake of DTZ by hepatocyte is extremely fast and PB enhances the hepatic intrinsic metabolic clearance of DTZ.
탄성 링을 갖는 볼 베어링 지지의 터보 펌프 임계 속도에 관한 연구
이용복,김창호,곽현덕,하태웅,우유철,Lee, Yong-Bok,Kim, Chang-Ho,Kwak, Hyun-Duck,Ha, Tae-Woong,Yoo, Woo-Chul 한국유체기계학회 2001 한국유체기계학회 논문집 Vol.4 No.2
This study was performed to evaluate the dynamic behavior of turbo pump unit. The acceptable separate margin of $1^{st}$ critical speed was obtained by the use of elastic-ring inserted ball bearing, while the poor separate margin of $1^{\st}$ critical speed was appeared in the case without the elastic-ring. In addition, the results show that the stiffness and damping of plain seals give more separate margin of $2^{nd}$ critical speed. However the wear or the failure of seals could reduce the $2^{nd}$ critical speed near the operating speed.