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Multitest CMI를 이용한 위암 및 대장암 환자의 세포성 면역능의 검투
이심원,문철,송영식,허경발 순천향대학교 1986 논문집 Vol.9 No.2
To assess cell mediated immunity, delayed type hypersensitivity reaction of patients with gastrointestinal tumors and healthy subjects were comparatively studied. For the test, Multitest CMI kit(Institut Merieux) was used, which applies 7 standardized recall antigens(tetanus, diphtheria, streptococcus, candida, trichophyton, proteus) and a 70% w/v glycerin diluent control and is commercially available for the simple test to evaluate post therapeutic and prognostic effect of patients treated. The purpose of the study is to have a standardized cell mediated immunity data on such korean patients and healthy subjects. The results were: 1) In almost all patients the skin reactivity and rate of positive responses to 7 recall antigens were decreased than control group and the order of stimulatory degree were tuberculin, diphtheria toxoid and the poorest antigen was the tetanus toxoid. 2) Average score of the cancer patients was 9.34 mm and the average number of positive response was 2.24, which were significantly lower than those of control(17.78mm, 3.72). 3) Average score of the control group under age 60 was 20.26 mm and at over 60 the value was 10.33 mm. When these were compared by the sex, the average score and the number of positive response in male were 23.35 mm, 4.53, respectively. In female, the value were 12.79 mm, 3.0, which were decreased than male. 4) Among cancer patients, 10.8% of them develop energy and the incidence rate appeared to be increased by the progress of the disease. 5) Total number of lymphocytes, T-cells active T-cells in cancer patients were significantly lower than those of control group, which were quite comparable to those obtained by the Multitest CMI. Thus, it was tentatively concluded that above results obtained by delayed cutaneous hypersensitivity using multiple recall antigens were reproducible and matched well with the data obtained by the conventional methods, which can be applicable to evaluate the results of treatment and prognostic values by measuring CMI of cancer patients.