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신공여자특이수혈에 따른 면역학적변화가 Cyclosporine - A 를 사용한 이식신의 예후에 미치는 영향
박능화(Neung Wha Park),지상근(Sang Keun Ji),최현묵(Hyun MOok Choi),김영우(Young Woo Kim),이신화(Sin Wha Lee),양상호(Sang Ho Yang),임학(Hark Rim),이재우(Jae Woo Lee),이승도(Seung Do Lee) 대한내과학회 1996 대한내과학회지 Vol.50 No.5
N/A Objectives: Donor specific transfusion (DST) prior to kidney transplantation has been widely accepted due to its beneficial effect on the graft survival. The mechanisms of protective effect of DST are not clearly understood, although several hypotheses have been suggested including alterations of cell mediated immunity. The significance of DST, however, tends to be decreased following introduction of cyclosporine. Therefore, we investigated the prognostic effect of mixed lymphocyte culture (MLC) an<i other cell mediated immunological changes induced by DST. Methods: 98 HLA-haploidentical renal transplants operated during the period of 1985 through 1991 were evaluated. Among these 48cases were DST group and the remainder was control group. Immunological indices including MLC were examined and graft survivals were analyzed. Graft loss was de- fined as a loss of its function requiring dialysis. Results: 1) Following DST, stimulation index of MLC was significantly suppressed from 4.0.0.4 (mean±S.E.) to 2.6±0.1 (p<0.(E), Relative response appeared to be decreased after DST from 61.1±6.0% to 49.9±3.1%, although thc difference was not statistically significant. 2) No significant changes in CD3, CD4, CD8, DR' cell, T-cell stimulation test by PHA and spontaneous lymphocyte transformation were found after DST. For all indices there was no significant difference between the post DST and control groups. 3) The actuarial graft survival rates for 1 and 5 years were 94±4% and 75±57%, respectively, in DST group and 904Fo and 69±14%, respectively, in control group. The graft survivals of DST and control groups were not significantly different. 4) The 1- and 5-year graft survival rates were 94±4% and 71±8%, respectively, in the DST group with the SI value over 2.0, and 92±7% and 85±10%, respectively, in the DST group with SI value lesser than 2.0. 5) The 1- and 5-year graft survival rates were 91±5% and 72±8%, respectively, in the DST group with RR value greater than 40%, and 100% and 85±105, respectively, in the DST group with RR value lesser than 40% Conclusion: These results suggest that although DST suppresses stimulation index, it could not improve graft survival in HLA-haploidentical renal transplants treated with cyclosporine.
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李鐵煥,姜信和 진주여자전문대학 1986 論文集 Vol.8 No.-
Physical education is usually defined as "education of the physical" or "education through the physical", and also recently called the science and art researching "human movement". Form the view of traditional philosophy, the experimentalists put the aims of physical education on total fitness, the realists put them on physicai fitness or sports skill, and the idealists put them on humanity development. As stated above physical education can not be separated from the body, no matter how physical education may be defined and no matter where the aims of physical education lies. Here we can not but examine the relation between physical education and the sprit. As philosophical approach on the body and the sprit and psycho-physical medicine develops, the body is not considered to be separated from the sprit. We therefore come to think "physical education is education through the physical". according to the understanding of human nature that the wholeness of individual is an outstanding fact. Human sprit and body is the one by its nature, so sprit and body cannot be considered as separate substances. Though a certain human life is partial and sectional, it is the reaction of the individual wholeness and the life has influence on the individual wholeness. From this viewpoint, we should consider the relation between physical education and the play, which is thought as homo condition and is simultaneously established with human rooted conduct. Physical education should also understand that human being is the existence with life, action and body physical education has to follow the law of life preservation, trust the possibility of adjustment and action caused by it, contribute to "Good life", and understand that human being is wholeness of sprit and body. And also physical education should understand that human body is the acting as well as the meterial body.
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