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이성우,황방연,김세은,김환묵,김영호,이경순,이정준,노재섭,Lee, Sung-Woo,Hwang, Bang-Yeon,Kim, Se-Eun,Kim, Hwan-Mook,Kim, Young-Ho,Lee, Kyong-Soon,Lee, Jung-Joon,Ro, Jai-Seup 한국생약학회 1995 생약학회지 Vol.26 No.4
Preliminary screening test of modulators for multidrug resistance with 400 medicinal plants was carried out by using human multidrug resistance cell line, KB-V1. Among active medicinal plants, the unripe fruits of Evodia officinalis showed a potent modulating activity of MDR. From MeOH extract of this plant, we isolated two indole alkaloids, rutaecarpine (1) and evodiamine (2), by repeated silicagel column chromatography. Rutaecarpine increased the cytotoxicities of vinblastine and taxol against multidrug resistance cells, but evodiamine showed no modulating activity in spite of its potent cytotoxic activities.
심층탐구 / 21세기 지식사회에 대응한 특허 정보 정책
이성우,Lee, Seong-U 한국데이터베이스진흥원 2000 디지털콘텐츠 Vol.9 No.-
발명가나 일부 기업들에게만 관심이 있던 특허는 최근에 들어 인터넷 붐을 타고 비즈니스모델이 특허의 논란이 되면서 일반인에게 관심거리로 떠오르고 있다. 이미 수면위로 상승한 세계적인 이슈인 체세포 복제기술은 숱한 뉴스거리를 생산하며 계속적인 이슈로 부각되고 있다. 유념해야 할 점은 좋은 기술을 개발하고도 특허에 대한 무지로 재산권형성에 실패하는 경우가 종종 있다는 것, 뒤늦게 특허 분쟁에 휘말리는 경우 등을 보더라도 현대 기술 사회를 살아감에 있어서 기술개발의 첨병역할을 하고 있는 벤처기업들은 특허법에 대한 숙지가 무엇보다 중요하다고 할 것이다.
이성우,김광래,손봉세,Lee, Seong-U,Kim, Gwang-Rae,Son, Bong-Se 대한기계학회 2000 大韓機械學會論文集A Vol.24 No.10
Harmonic resonances in a continuous rotating shaft with distributed mass are discussed. The restoring force of the shaft has geometric stiffening nonlinearity due to the extension of the shaft centerline. The effect of a distributed lateral force, such as the gravity, is assumed. The possibility of the occurrences of harmonic resonances, the shapes of resonance curves, and internal resonance phenomena are investigated.
이성우,Lee, Seong-U 한국건강관리협회 1988 건강소식 Vol.12 No.9
지난 8월 25일 개최된 건협 언론인 초청 간담회에서 이성우 보건국장은 '일차보건의료와 예방시책'이라는 주제를 가지고 우리나라 국민 건강 관리 시스템의 예방시책 방안을 얘기했다. 이 글은 이국장의 발표문을 게재한 것이다.
Primo Vessel Inside a Lymph Vessel Emerging From a Cancer Tissue
이성우,임재관,류연희,Jin-Myung Cha,Jin-Kyu Lee,소광섭,김성철 사단법인약침학회 2012 Journal of Acupuncture & Meridian Studies Vol.5 No.5
Primo vessels were observed inside the lymph vessels near the caudal vena cava of a rabbit and a rat and in the thoracic lymph duct of a mouse. In the current work we found a primo vessel inside the lymph vessel that came out from the tumor tissue of a mouse. A cancer model of a nude mouse was made with human lung cancer cell line NCI-H460. We injected fluorescent nanoparticles into the xenografted tumor tissue and studied their flow in blood, lymph, and primo vessels. Fluorescent nanoparticles flowed through the blood vessels quickly in few minutes, and but slowly in the lymph vessels. The bright fluorescent signals of nanoparticles disappeared within one hour in the blood vessels but remained much longer up to several hours in the case of lymph vessels. We found an exceptional case of lymph vessels that remained bright with fluorescence up to 24 hours. After detailed examination we found that the bright fluorescence was due to a putative primo vessel inside the lymph vessel. This rare observation is consistent with Bong-Han Kim’s claim on the presence of a primo vascular system in lymph vessels. It provides a significant suggestion on the cancer metastasis through primo vessels and lymph vessels.