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한국 군장병 삼일열 말라리아(P. vivax) 진단에 OptiMAL 검사와 GENEDIA Malaria (P. vivax) Ab Rapid I, II 검사의 비교
조덕,임재균,이상오,소병조,임채승,양동욱 대한감염학회 2001 감염 Vol.33 No.4
Background : The diagnosis of malaria has been usually made using microscopic examination of Wright stained thin blood films in Korean army. This method is labor-intensive, time consuming and requires the microscopic expertise. Therefore, the alternative techniques, rapid diagnostic test, have been sought for use in Korean army. We performed a comparison of the OptiMAL test with GENEDIA Malaria (P. vivax) Ab Rapid I, II to assess its sensitivity and specificity of Plasmodium vivax malaria. Methods : Blood specimen were collected from 51 patients who were presented and initially diagnosed for P. vivax by the microscopy of blood smears and from 30 control patients without malaria infection at the Capital Armed Forces General Hospital (CAFGH) between October 2000 and February 2001. Among the 51 patients, we also collected 24 samples from 24 patients at 2 or 3 days after therapy. The OptiMAL test and GENEDIA Malaria (P. vivax) Ab Rapid I, II were performed according to the manufacturer's instructions on all samples respectively. Results : Compared with the blood firm, sensitivities and specificities of the OptiMAL test, GENEDIA Malaria (P. vivax ) Ab Rapid I and GENEDIA Malaria (P. vivax) Ab Rapid II were 94.1∼100% (29/29), 80.4∼83.3%, 96.1 ∼96.7% respectively. One case was interpreted as 'undetermined' by OptiMAL test. In 24 patients during therapy, the sensitivities of the OptiMAL test, GENEDIA Malaria (P. vivax) Ab Rapid I and GENEDIA Malaria (P. vivax) Ab Rapid II on 8 specimens with mean 120/□ parasitemia and 16 specimens with negative parasitemia were 75∼43.8%, 87.5∼81,3%, 100∼100% respectively. Conclusion : Our data demonstrated that the sensitivity and specificity of the GENEDIA Malaria (P. vivax) Ab Rapid I were not satisfactory, but the sensitivity and specificity of the OptiMAL test and GENEDIA Malaria (P. vivax) Ab Rapid II were relatively high and useful diagnostic tests for diagnosis of , P. vivax in areas like the militaries where laboratory facilities are poor or non-existent. (Korean J Infect Dis 33:267∼272, 2001)
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