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      • 약제 관련 서맥의 임상 경과

        유경보 ( Kyung Bo Yoo ),이선화 ( Sun Hwa Lee ),이경석 ( Kyoung Suk Rhee ),이강휴 ( Kang Hyu Lee ),이상록 ( Sang Rok Lee ),채제건 ( Jei Keon Chae ),김원호 ( Won Ho Kim ),고재기 ( Jae Ki Ko ) 전북대학교 의과학연구소 2010 全北醫大論文集 Vol.34 No.2

        배경 및 목적: 최근 약물과 관련되어 발생한 서맥성 부정맥의 예후에 대한 재평가가 이루어지고 있다. 본 연구는 약제 유발성 서맥으로 최초 진단받은 환자들의 임상 경과를 분석하여 그 예후를 평가하고자 하였다. 방법: 전북대학교 병원 심장내과에 2000년 1월 이후 약물 유발성 서맥으로 진단 받고 입원치료를 받았던 환자들을 대상으로 하여 의무기록 분석 및 전화상담을 통한 후향적 조사를 하였다 결과: 전체 환자 중 경과 관찰 기간 동안 영구적 심박동기 삽입술을 시행 받은 환자는 28명(26.9%)으로, 동기능 부전 증후군 군과 고도방실차단 군에서 각각 15명(/68, 22.1%)과 13명(/36, 36.1%)이었다 결론: 고전적으로 양호한 임상경과를 취하는 것으로 알려져 왔던 이차성 서맥성 부정맥 환자 상당수에서 유발인자가 없이도 서맥이 점차 진행하여 결국 영구형 인공심박동기 이식시술을 받게 된다. Background and Objectives: Recently, the prognosis of drug-induced bradyarrhythmias has been reported not as benign as previous considerations. We performed the investigations about the patients who had been diagnosed as drug-related bradyarrhythmias presenting it at first. Subjects and Methods: Medical records of those who had been admitted to Chonbuk National University Hospital due to drug-related bradyarrhythmias since January 2000 were investigated retrospectively and clinical follow-up was performed using phone call. Results: One hundred and four patients were enrolled. Mean age was 68±10(34-85) years. Underlying diseases that need relating drugs were hypertension (50, 48.1%), ischemic heart disease, atrial fibrillation, cardiomyopathy, etc. Most common single causative agent was β-blockers (53.0%) and the others were nondihydropyridine calcium channel blockers (18.9%), digoxin (10.6%), antiarrhythmics (9.1%) and herb-medications (3.8%). 68 patients showed sinus node dysfunction (SND, 65.4%) and 36 showed AVB (34.6%). Mean heart rate on admission was 37.0±7.1 beats/minute. Permanent pacemaker implantations were performed in 28 patients (26.9%). Fifteen among them were with SND (15/68, 22.1%), 13 were with AVB (13/36, 36.1%). Conclusion: Unlikely to the general considerations, it would be better to say that drug-related bradyarrhythmias are not drug-induced bradyrrhythmias itself, but unmasked underlying bradyarrythmias in substantial portion of the patients. Very close and cautious clinical monitoring should be performed, especially in patients with AVB.

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        간흡충증의 임상상

        송항용(Hang Yong Song),이경석(Kyung Suk Rhee),이수택(Soo Teik Lee),김대곤(Dae Kon Kim),안득수(Deuk Soo Ahn) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.1

        N/A Background/Aims: Clonorchis sinensis, the Chinese liver fluke, is an important human parasite and is widely distributed in Southern Korea, China, Taiwan, Japan and Eastern Asia. Methods: To understand the more extensive clinical feature of clonorchiasis, we carried out an investigation retrospectively for hematology, blood biochemistry, clinical symptoms, and radiologic findings on a total of 309 clonorchiasis patients whose stools were positive for eggs of clonorchis sinensis at Chonbuk univeristy hospital. Results: 309 patients(270 males and 39 females) aged between 18 and 78 years. Common symptoms were right upper quadrant pain in 43 cases(13.9%), generalized weakness in 39 cases(12.6%), and jaundice in 39 cases(12.6%), and hepatomegaly in 25 cases(8%). 87 out of 250 cases(34.8%) showed normal eosinophilic count. The level of ALT was normal in 237 out of 303 cases(78.2%). The patients with more than 101 unit of ALT were 35 out of 303 cases(11.6%). In 131 patients among 275 cases, alkaline phosphatase value were in the normal limit(47.6%). As for ultrasonography, we couldnt find out abnormal findings in 62 out of 122 cases(51.8%). But 16 out of 122 cases(13.1%) showed the peripheral intrahepatic duct dilatation. And 14 cases(11.5%) showed the echoes of worms of clonorchiasis in the gall bladder. In 11 out of 46 cases(32.4%), abdominal CT showed diffuse dilatation of the periphera1 bile ducts. In 57 out of 81 patients(70.4%), there were positive reaction in intradermal test for clonorchis sinensis. And they had cross reaction with paragonimiasis in 23 out of 81 cases(28.4%). Conclusions: In the view of the results so far achieved, the result of our investigation is wide difference acompared with others report for clonorchiasis. We thought this difference is probably due to include more lightly infected persons by clonorchis sinensis in our .tudy group. So we suggest, to understand the clinical manifestation of clonorchiasis, it is necesssary to carry out examination for ultrasonography, abdominal CT and laboratory finding of patients depend on the number of worms, infection period, intensity and complication. (Korean J Gastroenterol 1995;27:64-71)

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