메리골드(Marigold) 에탄올 추출물의 S. mutans, P. gingivalis에 대한 항균력과 성장억제 효과

윤현서(Hyun-Seo Yoon),박충무(Chung-Mu Park) 한국구강보건과학회 2024 한국구강보건과학회지 Vol.12 No.1

일부지역 성인들의 구강보건교육 경험에 따른 구강건강관리 인식수준

윤현서(Hyun-Seo Yoon),채유정(You-Jung Chae) 한국구강보건과학회 2017 한국구강보건과학회지 Vol.5 No.2

The purpose of this study was to investigate the level of perception of oral health care according to oral health education experience. For this study, 300 adults in the Busan area were surveyed for 3 months. In the case of oral health education in oral hygiene management, there were many cases of brushing before breakfast (p = 0.037) and correct brushing (p <0.001). The recognition level of oral hygiene products was also high, 2.92 points (p = 0.001). Among oral hygiene products, the use of interdental toothbrushes (p = 0.001) and tongue cleaners (p = 0.025) were more frequent. The experience of oral health education in fluoride perception was high (p = 0.043) and fluoride experience was high (p = 0.025). If you have experience of oral health education in both oral hygiene management and fluoride awareness, you will improve your awareness levels. By developing and systematically educating oral health education programs, awareness levels can be improved.

부정교합 종류에 따른 교정치료의 인식과 구강건강영향지수(OHIP-14)

윤현서(Hyun-Seo Yoon) 한국산학기술학회 2017 한국산학기술학회논문지 Vol.18 No.12

본 연구는 부산지역 교정환자를 대상으로 부정교합의 종류와 교정치료에 대한 인식이 삶의 질에 미치는 영향을 파악하고, 부정교합의 종류에 따른 맞춤형 교육프로그램을 개발하여 삶의 질 향상의 기초자료로 삼고자 한다. 2015년 12월부터 약 6개월간 설문조사하여 최종 472부를 분석하였다. 연구결과는 부정교합의 가족력은 I급은 없음, II급, III급은 있음으로 응답하였고, 교육 실천은 자주실천에서 부정교합의 종류에 따른 차이를 보였다(p=0.003). 교정치료의 만족감에서는 불편감은 I급은 기간, II급과 III급은 통증(p=0.035)이였고, 통증부위에서는 치아가 가장 많았으나 II급에서 가장 높아 차이를 보였다(p<0.001). 교정치료 만족도에 따른 삶의 질에서는 현재 만족도가 높을수록, 자신감이 보통인 경우 삶의 질이 높았으며, 교정치료 시작 계기에서는 발음문제(p=0.013), 저작 불편감(p<0.001), 턱관절 소리(p<0.001)가 있는 경우 삶의 질이 낮았다. 구강 건강관련 삶의 질에 미치는 요인으로는 교정치료시기(p<0.001), 현재 만족감(p<0.001), 자신감 변화(p=0.003), 주관적 치아상태(p=0.008), 교합의 종류(p=0.019)순으로 영향을 미쳤다. 따라서 교정치료를 받는 환자들의 구강건강 상태를 면밀하게 분석하고 맞춤형 교정상담프로그램을 통하여 교정기간에도 삶의 질을 향상시킬 수 있어야 한다. The purpose of this study was to examine the influence of type of malocclusion and orthodontic treatment awareness on quality of life among orthodontic patients in the region of Busan as well as to develop an educational program tailored to the type of malocclusion as a way to improve quality of life. A survey was conducted for approximately 6 months from December, 2015, and the answer sheets from 472 respondents were analyzed. The most common painful area was the teeth, and this case was most predominant in the respondents with level 2 malocclusion, who differed from others in that regard (p<0.001). Regarding the relationship between satisfaction with orthodontic treatment and quality of life, respondents who were more satisfied currently and who were neither quite confident nor quite unconfident were ahead of their counterparts in quality of life. Concerning the reason for receiving orthodontic treatment, quality of life was lower among patients who started to receive treatment due to pronunciation problems (p=0.013), chewing difficulty (p<0.001), and temporomandibular joint click sound (p<0.001). With regard to influential factors on oral health-related quality of life, time for starting to receive orthodontic treatment was most influential (p<0.001), followed by current satisfaction (p<0.001), changes in confidence (p=0.003), self-rated teeth status (p=0.008), and type of occlusion (p=0.019). Therefore, accurate analysis of the oral health status of orthodontic patients and customized oral health education are required to improve quality of life even during the period of orthodontic treatment.

일부지역 대학생의 치과 의료기관 선택요인에 관한 연구

윤현서(Hyun-Seo Yoon),강현영(Hyun-Young Kang),홍인경(In-Kyoung Hong),김혜진(Hye-Jin Kim),이민경(Min-Kyung Lee),이정화(Jung-Hwa Lee),진혜정(Hye-Jung Jin) 한국구강보건과학회 2014 한국구강보건과학회지 Vol.2 No.1

The purpose of this study was to examine the selection factors of college students in the region of Busan for dental institution. A survey was conducted by visiting the selected students in September, 2013, and an online survey was additionally conducted. The answer sheets from 300 respondents were analyzed. They relied on their past experience(3.85) in terms of information search, and they took considerations on how long it took to get to the dental institution(3.97) in terms of traffic convenience. As for physical environments, they gave priority to cleanness(4.66). Concerning the image of dental institution, they took reputation into account(4.25). In terms of external qualifications, they placed importance on the academic credential of dentist(3.22). As to dental service for the selection of dental institution, they gave weight to dentist ability(seven). In regard to basic elements, they took considerations on treatment cost(4.12), and they especially placed the most importance on dentist ability. The male and female students gave 4.32 and 4.48 respectively to dental service for the selection of dental institution, and the gender difference was significant. Among the selection factors of dental institution, there was a weak positive correlation between traffic convenience and physical environments, between physical environments and the image of dental institution and between dental service and basic elements. Therefore various efforts should be made to offer quality medical service by keeping track of what s considered in choosing a dental institution.

부산·경남지역 대학생들의 안면외상에 대한 지식수준

윤현서(Hyun-Seo Yoon),정은경(Eun-Kyung Jung) 한국구강보건과학회 2016 한국구강보건과학회지 Vol.4 No.2

The purpose of this study was to examine the level of the knowledge of college students on oral trauma in the region of Busan and Gyeongsangnam-do Province. A survey was conducted on the selected college students who resided in these areas during a three-month period of time from March, 2015, and the answer sheets from 290 respondents were analyzed. As for oral trauma experience according to characteristics, more trauma experiences were found among the respondents who were older (p=0.002), whose allowance was larger (p=0.047) and whose workout frequency was higher (p=0.011). Regarding the characteristics of oral trauma including the reasons, bumping(16.6%) was the most dominant reason, and the most common injury was tooth fracture(16.9%). The most widely injured position was upper central incisor(18.6%). As to the necessity of education, as many as 80.7% considered related education to be necessary. As to age, the respondents who were aged between 18 and 22 had a significantly better knowledge about tooth fracture (p=0.038), tooth fracture (p<0.001) and tooth mobility (p=0.043) on the whole. As for the track of major, the health-related majors were more knowledgeable, and they had a significantly better knowledge on tooth fracture (p<0.001) and lip injuries (p=0.005). In regard to monthly allowance, the students who had 300 thousand won or less of monthly allowance had a significantly better knowledge of tooth mobility (p=0.005), and the students whose monthly allowance was between 310 and 600 thousand won had a significantly better knowledge on lip injuries (p=0.003). As to weekly drinking frequency, the respondents whose drinking frequency was larger had a less knowledge in general, and there were significant differences between them and the others in knowledge of tooth fracture (p=0.002), tooth fracture (p=0.010) and tooth mobility (p=0.032). Therefore it will be possible to prevent oral trauma if educational programs are developed to provide education on that.

Dipeptidyl peptidase 4 (DPP4)/CD26 : Biological Functions, Disease Association, and Therapeutics

윤현이(Hyunyee Yoon),송문정(Moon Jung Song) 고려대학교 생명자원연구소 2021 생명자원연구 Vol.29 No.-

Dipeptidyl peptidase 4 (DPP4), 또는 CD26 단백질은 세포막 바깥쪽 도메인에 단백질의 2번 위치에 존재하는 프롤린이나 알라닌 잔기를 절단하는 dipeptidyl peptidase 효소활성을 갖는 다기능 당단백질이다. 세포내 중요한 신호전달 인자로 작용하는 다양한 생리활성 물질들이 DPP4의 기질이기 때문에, DPP4는 당대사 조절, 항염증반응 및 심혈관대사 작용에 중요한 역할을 한다고 알려져 있다. 흥미롭게도 고병원성 사람코로나바이러스인 MERS-CoV의 세포수용체로서 DPP4의 역할도 보고되었다. DPP4는 관련된 많은 질환에서 중요한 약물 표적으로 여겨져 왔기 때문에, 본 논문에서는 DPP4의 생물학적 기능, 질병연관성, 치료제 등에 관한 내용을 살펴보고자 한다. Dipeptidyl peptidase 4 (DPP4; also known as CD26) is a multifunctional glycoprotein containing an ecto-domain with didpetidyl peptidase enzymatic activity that cleave the proteins containing a position 2 proline or alanine. Since there are a variety of bioactive DPP4 substrates acting as important signaling messengers, DPP4/CD26 is shown to play key roles in transducing the glucoregulatory, anti-inflammatory, and cardiometablolic actions. Moreover, DPP4 can function through protein-protein interactions to exert its biological functions, regardless of its enzymatic activity. Interestingly, DPP4 was identified as a host receptor for middle east respiratory syndrome coronavirus (MERS-CoV), a highly pathogenic human coronavirus. Since DPP4 has been a critical therapeutic target for many related diseases, in this review, we will discuss the current understanding of DPP4/CD26 regarding its biological functions, disease association, and therapeutic approaches.

Relationship between the Estimated Glomerular Filtration Rate and the Urine Microalbumin/Creatinine Ratio and Ferritin in Korean Adults

윤현,이준호,Yoon, Hyun,Lee, Jun Ho Korean Society for Clinical Laboratory Science 2019 대한임상검사과학회지(KJCLS) Vol.51 No.2

본 연구는 대한민국 성인에서 eGFR 및 uACR과 Ferritin의 관련성에 대한 연구이다. 2012년 국민건강영양조사자료에서 20세 이상의 4,948명을 대상으로 관련변수를 보정한 후, 만성신장질환(CKD, eGFR<$60mL/min/1.73m^2$) 및 알부민뇨($uACR{\geq}30mg/g$)에 따른 페리틴 수준을 분석하였다. 만성신장질환군의 ferritin 수준($M{\pm}SE$) [$103.04{\pm}6.59mL/min/1.73m^2$; 95% confidence interval (CI), 90.12~115.96]은 정상군($84.87{\pm}1.16mL/min/1.73m^2$; 95% CI, 82.59~87.14)에 비하여 유의하게 높았다(P=0.007). 그러나 정상군($82.72{\pm}4.09mg/g$; 95% CI, 74.71~90.73)과 알부빈뇨군($82.72{\pm}4.09mg/g$; 95% CI, 74.71~90.73)의 ferritin 수준은 유의한 차이가 없었다(P=0.487). 결과적으로, 대한민국 성인에서 만성신장질환과 ferritin수준은 양의 상관관계가 있었지만, 알부빈뇨에서는 유의한 차이가 없었다. This study examined the relationship between the estimated glomerular filtration rate (eGFR) and urine microalbumin/creatinine ratio (uACR) with ferritin in Korean adults. This study included 4,948 adults aged ${\geq}20years$ from the 2012 Korea National Health and Nutrition Examination Survey (KNHANES) data. A covariance test adjusted for covariates was performed for the ferritin levels in relation to the decreased eGFR (eGFR<$60ml/min/1.73m^2$) and elevated uACR ($uACR{\geq}30mg/g$). Several key findings were made in the present study. First, after adjusting for the related variables, the ferritin level was higher in the decreased eGFR group [$103.04{\pm}6.59mL/min/1.73m^2$; 95% confidence interval (CI), 90.12~115.96] than in the normal eGFR group ($84.87{\pm}1.16mL/min/1.73m^2$; 95% CI, 82.59~87.14; P=0.007). Second, after adjusting for the related variables, the ferritin level ($M{\pm}SE$) was similar in the normal uACR group ($85.70{\pm}1.20mg/g$; 95% CI, 83.35~88.05) and elevated uACR group ($82.72{\pm}4.09mg/g$; 95% CI, 74.71~90.73) (P=0.487). Chronic kidney disease was positively associated with the ferritin level in Korean adults but albuminuria was not.

부산지역 65세 이상 노인의 구강건강과 자가건강평가수준(SRH)

윤현서 ( Hyun Seo Yoon ),전진호 ( Jin Ho Chun ),이정화 ( Jung Hwa Lee ) 한국치위생과학회 2012 치위생과학회지 Vol.12 No.3

The purpose of this study was to examine the impact of the oral health status and health care of elderly people on their self-rated health(SRH). The subjects on this study were 479 senior citizens who were at the age of 65 and up and resided in the city of Busan. They got a dental checkup, and a survey was conducted by having an one-on-one interview. After the collected data were analyzed, the following findings were given: The senior citizens were diagnosed with a mean of 1.43 systemic diseases, and hypertension(51.8%) was the most prevalent disease among them, followed by diabetes(25.1%), arthritis(41.8%), oral diseases(75.6%), stroke(9.0%) and heart diseases(15.9%). Their self-rated health was better when they were male, when they were aged between 65 and 69, when there was someone with whom they lived, when they were better educated and when they owned their own houses. But their self-rated health was poorer when they felt more oral symptoms, when they had more missing teeth and when they needed both of maxillary and mandibular dentures. Their self-rated health was more positively affected when they were better educated(β=0.894), when they owned their own houses(β=4.220), when they got a dental checkup on a regular basis(β=2.997) and when the rate of their functional tooth was larger(β=0.081). And that was more negatively influenced when they had a denture(β=-1.110), when they had more oral symptoms(β=-1.590) and when they had more systemic diseases(β=3.363). There is a close relationship between the oral health and self-rated health of elderly people. Therefore how to promote their oral health should carefully be considered.

부산지역 병의원을 내원하는 성인의 구강건강 인식수준이 삶의 질에 미치는 영향

윤현서(Hyun-Seo Yoon) 한국산학기술학회 2017 한국산학기술학회논문지 Vol.18 No.10

본 연구는 부산지역 병의원에 내원하는 성인을 대상으로 주관적 인식수준에 따른 삶의 질을 알아보고 영향요인을 분석하여 주관적 인식개선을 위한 방안마련과 함께 삶의 질 향상을 위한 기초자료로 삼고자 한다. 2015년 12월부터 약 9개월 간 부산지역 병의원에 내원하는 성인들을 대상으로 설문조사를 실시하여 결과는 다음과 같다. 주관적 건강수준에서 여자가 3.16점으로 높았고, 연령은 높아질수록 낮았으며, 비 흡연자에서 3.17점으로 높았고, 주관적 구강건강수준은 연령이 높을수록 낮았고, 최종학력에서는 대졸이상이 3.04점으로 가장 높았으며, 흡연을 하지 않는 경우 2.87점으로 높았다. 증후증상 합은 여자가 1.41점으로, 연령이 낮을수록 증상의 인식이 없었다. 최종학력은 높을수록 월 소득은 많을수록, 비 흡연자에서 구강 내 증상 인식수준이 낮았다. 일반적 특성에 따른 삶의 질을 분석한 결과, OHIP-14는 최종학력이 높을수록, 전신질환 없는 경우 54.71점으로 높았으며, 단일문항 행복지수는 학력이 높을수록, 전신질환이 없는 경우 6.48점으로 높았다. 또한 5문항 행복지수는 학력이 높을수록, 전신질환이 없는 경우 3.82점으로 높았다. OHIP-14에 미치는 요인으로 증후증상 합이었으며, 행복지수, 주관적 구강건강상태순 등으로 영향을 미치는 것으로 나타났다. 행복지수에 가장 큰 영향력을 미치는 변인은 OHIP-14이었으며, 주관적 건강상태, 학력_고졸이하, 만성질환 유무 순 등으로 영향을 미치는 것으로 나타났다. 따라서 삶의 질 향상을 위해서는 주관적인 인식수준의 개선이 필요하며, 인식수준개선을 위한 다양한 보건교육프로그램과 함께 정확한 정보를 전달할 수 있는 장의 마련이 필요할 것으로 사료된다. The purpose of this study wasto determine the quality of life according to the level of subjective perception as well asto analyze the influencingfactors and improve the subjective perception to improve the quality of life. The results of the survey for adult patients in hospitals and neighborhood clinics in the region of Busan for nine months from December 2015 were as follows. Regarding the total symptoms, the women had a score of 1.41, and the younger respondents felt they suffered from no symptoms. An analysis of the quality of life by the general characteristics showed that the respondents who were better educated and had no systemic diseases hada higher score of 54.71 on the OHIP-14. The respondents who were better educated and had no systemic diseases hada higher score of 6.48 when a single item was used to determine their happiness index, and the respondents who were better educated and had no systemic diseases hada higher score of 3.82 when five items were used to rate their happiness index. The factor with the greatest influence on their scores on the OHIP-14 was the total symptoms, followed in order by the happiness index and self-rated oral health status. The variable that exerted the largestinfluence on the happiness index was the OHIP-14, followed by the self-rated health status, high-school or lower education, and the presence or absence of one or more chronic disease. Therefore,animprovement inthe subjective awareness level is required to boost the quality of life, and a variety of health education programs should be prepared to raise the awareness level. In addition, there should be a chance to convey accurate information.

일부 병원 종사자들의 치과위생사에 대한 이미지 선호 경향

윤현서 ( Hyun Seo Yoon ),김정술 ( Jung Sool Kim ),이미옥 ( Mi Ok Lee ),김현대 ( Hyun Dae Kim ) 한국치위생과학회 2010 치위생과학회지 Vol.10 No.4