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윤태철,박동수,김진 大韓齒科保存學會 1992 Restorative Dentistry & Endodontics Vol.17 No.1
Periapical lesions are developed as a result of inflammatory response to irritants from root canal system. Clinicians remove these irritants from root canal system and seal the root canal space to induce healing of the periapical lesions. Immunopathologic responses may play an impostant role in development ans progression of periapical lesions ans periapical lesions contain immunocompetent cells. The purposes of the present study were to analys and to compare the distrebution of the immunocompetent cells in the human periapical lesions caaording to the stage of endodontic treatment using indrect immunoperoxdase technique. Obtained 94 human periapical lesions were devided into four groups : Group 1 : no endodontic treatment(28 samples) Group 2 : root canal enlarged and irrigated(28 samples) Group 3 : root canal filied(29 samples) Group 4 : unknown(9 samples) Monoclonal antibodies to examine target cells were UCHL-1 for T lymphocytes(1:200, Dakopatt, Denmark), L26 for B lymphocytes(1:200, Dakopatt, Denmark), OPD4 for heper T lymphocytes(1:200, Dakopatt, Denmark) and alpha-1-antichymotrypsin for macrophages (1:200, Dakopatt, Denmark). The following results were obtained : 1.All the periapical lesions studied were infiltrated by T lymphocytes, plasma cell, B lymphocytes, and macrophages, T lymphocytes were more infiltrated than B lymphocytes, and B lymphocytes and macrophages were less infiltrated than T lymphocytes and plasma cell(P<0.05 : Oneway ANOVA test). 2. In untreated group and canal irrigated and enlarged group of all the periapical lesions, helper T lymphocytes were predominently infiltrated(P>0.05 : Oneway ANOVA test). 3. In canal filled groups of all lesions except periapical cyst, plasma cells were predominently infiltrated. But, in canal filled group of periapical cyst, helper T lymphocytes were the predominent cells(P>0.05 : Oneway ANOVA test). The above results shows that the immunologic responses play important role in pathogensis of periapical lesions and the immunologic response involved undergoes certain changes after endodontic therapy.
박동수,조수진,윤태철 大韓齒科保存學會 1995 Restorative Dentistry & Endodontics Vol.20 No.1
AbstractPeriapical lesions develop as a result of immunopathologic response to irritants from infected root canal systems. Removal of these irritants from the root canal system and sealing the root canal space may induce healing of the periapical lesions. 83 periapical lesions diagnosed as periapical abscess, periapical granuloma, chronic nons- pecific inflammation, fibrosis and periapical cyst were evaluated for the distribution of immu- noglobulin containing cells. The influence of the state of root canal treatment on the distribu- tion of immunoglobulin containing cells has evaluated. All lesions were divided into a group with no treatment, a group with canal enlargement, a group filled with gutta percha, and a group filled with VitapexC calcium hydroxide). The distribution of immunoglobulin-contai- ning cells according to the presence of pain and fistula was also evaluated.The following results were obtained. 1. Statistically significant difference in the distribution of immunoglobulin-containing cells among periapical abscess, periapical granuloma, chronic nonspecific inflammation/fibrosis and periapical cyst were found.(Kruskal-Wallis analysis, P<^0.05) The number of immu- noglobulin-containing cells in fibrosis was remarkably lower than that of periapical abs- cess, granuloma and cyst. 2. IgM and IgA containing cells were predominantly observed in periapical abscesses and periapical cysts, respectively. 3. All periapical lesions showed a large number of IgG containing cells followed by IgM, IgA and IgE containing cells. 4. There was a decrease in all Ig-containing cells in the group with canal filling compared to groups without treatment or with enlargement. That is, there is a decrease in Ig -containing cells as treatment progresses. 5. No significant correlation existed between the presence of pain and fistula and the distri- bution of immunoglobulin containing cells in periapical lesions, (t-test) Results appear to support that immune response are actively involved in the development and progress in periapical lesions. The fact that distribution of immunoglobulins differ according to the state of endodontic treatment suggests that root canal treatment may alter the humoral immune response of the periapical lesions.
이장재 도포 방법에 따른 표백제의 치경부 누출에 대한 연구
박동수,김성철,윤태철 大韓齒科保存學會 1995 Restorative Dentistry & Endodontics Vol.20 No.1
AbstractBases have been used in order to prevent the leakage of bleachingagents through dentinal tubules in bleached teeth.But the proximal surfaces where the actual resorption takes place havenot been protected.The purpose of this study was to compare the conventional basing method with the basing of the labial and two proximal surfaces to the cementoenamel junction.The bases were placed after conventional root canal treatment. Group I : 2mm thickness bases were placed to the level of labial cementoenamel junction line. Group II : 2mm thickness bases were placed to the level of all c-e J lines including cervical area. Control : No bases were placed.After placement of sodium perborate and 30% hydrogen peroxide mixtureinto the teeth, the changes of pH were measured.The results were as follows. 1. Group II showed smaller leakage of bleaching agents and was statistically significant difference compared to Group I.(p<0.05) 2. Group I showed no statistically significant difference compared to the control group. (p>0.05) 3. There were no significant among the upper and lower teeth groups in each group and between the groups.(p>0.05)According to the above results, it was considered that basing of thelabial and proximal surfaces to the cementoenamel junction can reduce the leakage of bleaching agents during bleaching procedure of pulplessteeth.