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        만성활동성간염에 대한 간추출제제의 임상효과

        문한규(Han Kyu Moon),심원보(Won Bo Shim),김지원(Ji Won Kim),조몽(Mong Cho),윤명순(Myung soon Yun) 대한소화기학회 1984 대한소화기학회지 Vol.16 No.2

        N/A The purified protein-free liver extracts have been used for past many years in the treatment of both acute and chronic liver diseases. To evaluate the therapeutic effect of liver extract, Adelavin, this clinical study was carried out in 25 HBsAg positive patients with histologically proven chronic active hepatitis. 4ml of Adelavin mixed with 5% dextrose in water 500 ml were infused intravenously daily for 4 weeks. The following results were obtained. 1) The subjective symptoms were improved after 4 weeks-administration by improvement rate 70% in fatigue, 60% in anorexia, 75% in nausea, 45% in indigestion, 67% in abdominal discomfort. 2) There were significant improvements in SGOT, SGPT, alkaline phosphatase, total protein after 2 weeks-administration than preadministration(p<0.01), in albumin after 4 weeks- administration (p<0.001), in prothrombin time after 3 weeks-administration (p<0. 05) 3) In serum protein electrophoresis, there was significant increase of albumin after 4 weeks- administration (p<0.001) and significant decrease of gamma globulin after 4 weeks-admini stration (p<0.001). 4) In radioimmunoassay, there was no change of Hepatitis B marker after 4 weeks-administration. 5) There was not any abnormality in complete blood count and urinalysis after 4weeks- administration, but the transient nausea was found in one patient, the mild acne in two patients, the skin rash with fever in one patient.

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