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- 저자 : 윤경식(Kyoung-Sik Yoon) (검색결과 3 건)
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윤재석(Jaesuk Yun),윤경식(Kyung Sik Yoon),이용섭(Yong-seop Lee),한경문(Kyoung moon Han),차혜진(Hye Jin Cha),신지순(Jisoon Shin),김영훈(Young-Hoon Kim),박혜경(Hye-Kyung Park),김형수(Hyung Soo Kim) 대한약학회 2017 약학회지 Vol.61 No.2
Narcotics, psychotropic substances, and marihuana are controlled by ‘Act on the control of narcotics, ETC’, ‘the 1961 Single Convention on Narcotic Drugs’, or ‘the 1971 Convention on Psychotropic Substances’. However, the abuse of new psychoactive substances (NPS) is an emerging problem in Korea. According to the United Nations Office on Drugs and Crime (UNODC), about 600 NPS are defined and rapid identification methods for NPS need to be developed. Nevertheless, several counter measures have been enforced in Korea. In the present study, 33 NPS including synthetic cannabinoids, phenethylamines, tryptamines, and aminoindanes were tested using Marquis, Duquenois-Levine, Zwikker, Madelin, and Liebermann reagents. Furthermore, we suggested a coloring test sequence for the preliminary identification of unknown substances.
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자외선B 조사 및 수종의 자외선차단제가 Hairless Albino Mouse의 피부노화에 미치는 영향
최재영 ( Jae Young Choi ),윤경식 ( Kyoung Sik Yoon ),조용호 ( Yong Ho Cho ),김낙인 ( Nack In Kim ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.2
Background: Photoaging skin is clinically characterized by wrinkled, dry, inelastic and irregularly pigmented skin, skin tumor and histologically by increased epidermal thickness, nurnerous fibroblasts, mast cells and inflammatory cells in the upper dermis, elastosis, degeneration of collagen fibers, increased proportion of type III collagen fibers in the dermis and increased numbers of keratinizing cysts in the lower dormis of hairless albino mouse skin. Chronic exposure to UVB induces photoaging skin and sunscreen agents are used to prevent photodamage to skin and reduce the incidence and extent of the chronic photoaging effects. Objective : To evaluate the photoaging effects of UVB on the skin and to assess the ability of sunscreen agents to protect the skin from photoaging, we examined the clinical, histological and quantitative changes in collagen in the skin of Albino hairless Skh: HR-1 mice. Materials and Methods : The experimental animals were male Albino hairless Skh: HR-1 mice, 12 weeks old. The control group was a chronologically aging group which had not been affected by UVB irradiation. The non-protected group was irradiated with UVB, a half of MED, 3 times weekly(Monday, Wednesday, Fr iday), for 12 weeks. To assess the photoprotective effects of sunscreen agents, the control group, the non-protected group and the sunscreen agent-applicated groups were compared to each other clinically, histologically, and by quantitative collagen analysis. An early increase in type III collagen during UVB irradiation was determined by cyanogen bromide digestion of the whole skin, sodium dodecyl sulfate-polyacrylamide gel electrophoresis and densitometry. Results : Clinically, the skin of the mice in the non-protected group showed mild changes caused by photoaging. Histoloically, the non-protected group showed increases in the size and number of keratinizing cysts in the lower dermis and increases in the mast cells in the upper dermis compared with the control group. However, no significant findings of increased epidermal thickness, inflammatory cell infiltration, elastic fiber change or degeneration of collagen fibers were shown. By the 12th week, four of the total of nine mice in the non-protected group developed at least one tumor. The sunscreen agent applicated groups showed slightly photoprotected effects clinically and histologically. In the collagen analysis, the proportion of type III collagen was significantly increased in the photoaging skin of mice in the non-protected group compared with the control group. Mice in the sunscreen agent applicated groups showed a significantly decreased proportion of type III collagen compared with the non-protected group. Conclusion : To summarize, UVB exposure of the skin induces photoaging. The number and size of keratinizing cysts increased in the photoaging skin of hairless albino mice. There was also a quantitative change in the collagen fibers. The use of sunscreen agents decreases the photoaging effects of UVB on the skin. (Kor J Dermatol 1996;34(2): 289-299)
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