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RISS 인기검색어
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- 저자 : 윤건호 ( Yoon Gun-ho ) (검색결과 3 건)
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당뇨병성 신증 및 신증후군 환자의 혈중 Lp ( a )
유순집,윤건호,이광우,손호영,권혁호,우제영,차봉연,강성구 한국지질학회 1993 韓國脂質學會誌 Vol.3 No.1
There are intimate relationship between dyslipidemia and atherosclerosis. The incidence and the mortality of cardiovascular disease increased in proteinuric disorder such as diabetic nephropathy and nephrotic syndrome. Recently there were evidence that increased concentrations of serum Lp(a), which is independent risk factor to atherosclerotic cardiovascular and cerebrovascular disease, in proteinuric disorder. We intended to search and identify the mechanism of altered concentrastions of Lp(a) in proteinuric disorder via measuring serum Lp(a) concentrations with ELIZA in 26 patients with diabetic nephropathy, 20 patients with nephrotic syndrome and 59 control. The results were as follows 1) There were significantly increased amounts of 24 hour urine protein in diabetic nephropathy group[DN](6.0±4.5 g/㎗) and nonremission group [R-](4.8±1.8 g/㎗) of nephrotic syndrome compared to remission group[R+](0.7±0.4 g/㎗) (p$lt;0.05) and significantly decreased serum albumin level in [R-](2.2±1.3g/㎗) compared to [DN](3.1±0.6g/㎗) and [R+](3.4±0.8g/㎗) (p$lt;0.05) and significantly decreased serum protein level in [R-](6.6±0.7g/㎗) compared to [R+](5.1±1.2g/㎗) (p$lt;0.05). 2) There were significantly increased level of total cholesterol and LDL-cholesterol in [R-](327.8±141.3 g/㎗ & 234.1±129.7㎎/㎗) compared to [DN](246.6±66.4 ㎎/㎗) (p$lt;0.05), but no significant difference in triglyceride and HDL-cholesterol among [R-]. [R+] and [DN](p$gt;0.05). 3) There were significantly increased concentration of serum Lp(a) in [DN] [median 36.3 (range 4.0-164.0 ㎎/㎗)], [R+] [28.3 (15.0-145.0 ㎎/㎗)]. [R-] [130.5 (10.1-177.0 ㎎/㎗)] compared to control [median 13.0 (range 1.0-70.0㎎/㎗)](p$lt;0.05). And there were significant difference in serum Lp (a) concentration of [R-] compared to [DN] and [R+](p$lt;0.05). 4) There were significant correlations in serum Lp(a) concentrations with serum albumin, total cholesterol and LDL-cholesterol, but no significant correlations in age, sex, fasting blood sugar, serum creatinine, triglyceride, HDL-cholesterol and 24hr urine protein in proteinuric disorder. There were statistically significant increased concentrations of serum Lp(a) in proteinuric disorder compared to control group and the concentrations were variable according to kind and state of disease. The results suggested that increased hepatic synthesis of Lp(a) would be one of the mechanism of increased concentrations of serum Lp(a) in these proteinuric disorder and it would be relate to decreased level of serum albumin.
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