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신성 고혈압 쥐에서 Pinacidil에 의한 혈관 이완반응에 있어 산소유리기의 역할
염철호 ( Cheol Ho Yeum ),최석 ( Seok Choi ),유임준 ( Im Joon Yoo ),위희욱 ( Hee Wook Whi ),전제열 ( Jae Yeoul Jun ),김현일 ( Hyun Il Kim ),신혜랑 ( Hye Rang Shin ),오현정 ( Hyun Jung Oh ),정종훈 ( Jong Hoon Chung ) 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.6
Purpose: Evidence has emerged that oxygen-derived free radicals may induce vascular relaxations via ATP-sensitive K+ (KATP) channels and the level of free radicals is increased in animal models of hypertension. The present study was conducted to determine whether relaxations to an KATP channel opener, pinacidil, are increased in the aorta from two-kidney, one clip (2K1C) hypertensive rats and whether free radial scavengers reduce these relaxations. Methods: 2K1C hypertension was induced by clipping the left renal artery and age-matched control rats received a sham treatment. Rings of aortae without endothelium were suspended for isometric force recording. Results: Relaxations to pinacidil (10-8 to 10-5 M), which are abolished by glibenclamide (10-5 M), were augmented in the aorta from 2K1C rats, compared to those from control rats. In the aorta from 2K1C rats, catalase (1,200 U/mL), but neither superoxide dismutase (150 U/mL) nor deferoxamine (10-4 M), reduced relaxations to pinacidil, whereas in the aorta from control rats, the free radical scavengers did not affect these relaxations. Conclusion: These results suggest that in 2K1C hypertension, vasorelaxation to an KATP channel opener is augmented and that hydrogen peroxide in smooth muscle cells may partly contribute to these relaxations.
Arc Ion Plating 方式에 依한 TiCN 蒸着시 反應가스가 코팅층에 미치는 影響
서창민(Chang-Min Suh),김창근(Chang-Geun Kim),유임준(Im-Jun Yoo) 한국해양공학회 1997 韓國海洋工學會誌 Vol.11 No.3
This work was intended to study the effect of a partial pressure ratio and a total pressure of reactive gases on the properties of TiCxN1-x coated layer. In this regard, various TiCxN1-x coatings were synthesized with C₂H₂ and N₂ mixture gas of different compositions by Arc Ion Plating process which has been highlighted for an industrial purpose. It was revealed from colors and X-ray diffraction patterns that the concentration of carbon of a TiCxN1-x coating increases with a partial pressure ratio (PC₂H₂/PN₂) as well as a total pressure of C₂H₂ and N₂ mixture gas. Accordingly, the hardness of TiCxN1-x coated layer increased but the adhesion to the substrate of SKH 51 was degraded. On the other hand, the deposition rate was independent of a partial pressure ratio and a total pressure of mixture gas. It was found that a uniform gas distribution is critical for an industrial application since the composition of a coating depends strongly on the location of a substrate inside of the furnace. As a result of milling tests with different TiCxN1-x coated end mills, the one which has a low carbon concentration was better than others studied in this work.