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RISS 인기검색어
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- 저자 : 유영월 ( Yeong Wol Yu ) (검색결과 4 건)
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Cisplatin의 세포독성에 대한 레몬밤 추출물의 억제 효과
최유선 ( Yu Sun Choi ),김선주 ( Sun Ju Kim ),유영월 ( Yeong Wol Yu ),임요섭 ( Yo Sup Rim ),황은희 ( Eun Hee Hwang ),이화정 ( Hwa Jeong Lee ),최은영 ( Eun Young Choi ),장병수 ( Byung Soo Chang ),정인주 ( In Ju Jung ) 대한미용학회(구 대한미용과학회) 2013 대한미용학회지 Vol.9 No.1
The purpose of this study is to evaluate the protective effect of Lemon balm (Mellisa officinalis) extract on the cytotoxicity induced by cisplatin, pharmaceutic alopecia inducer. To achieve this, cisplatin-induced cytotoxicity was assessed by XTT assay after human skin fibroblasts (Detroit 551) were cultured in media containing various concentrations of cisplatin. And also, the effect of vitamin E was examined on the cisplatin-induced cytotoxicity. For the protective effect of Lemon balm extract on cisplatin-induced cytotoxicity, Detroit 551 cells were pretreated with 80 or 100 μg/mL of Lemon balm extract for 2 hours, and also, antioxidative effects of Lemon balm extract such as 1,1-diphenyl-2-picrylhydrazyl (DPPH)-radical scavenging activity and lactate dehydrogenase (LDH) activity were analysed. The results were as follows. Cisplatin showed a significant decrease of cell viability in dose dependently, and the XTT50 value was calculated at 25.7 μM. In the effect of vitamin E, it significantly increased cell viability which were decreased by the cisplatin-induced cytotoxicity. In the protective effect of Lemon balm extract on cisplatin-induced cytotoxicity, it significantly increased cell viability which was decreased by cisplatin-induced cytotoxicity, and also it showed the DPPH-radical scavenging activity and LDH inhibitory activity. Therefore, these results suggested that the cytotoxicity of cisplatin may be involved in oxidative stress, and also, Lemon balm extract effectively prevented the cytotoxicity induced by cisplatin via antioxidative effect. Conclusively, the natural extract like Lemon balm may be useful for the development as antioxidative agent via the prevention of the cytotoxicity induced by pharmaceutic alopesia inducer correlated with oxidative stress.
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보문 : 염모제 성분인 카드뮴의 세포독성에 대한 시엽추출물의 영향
손영우 ( Young Woo Son ),임요섭 ( Yo Sup Rim ),유영월 ( Yeong Wol Yu ),정인주 ( In Ju Jung ) 대한미용학회(구 대한미용과학회) 2012 대한미용학회지 Vol.8 No.1
This study was carried out to investigate the cadmium (Cd)-induced cytotoxicity and the protective effect of persimmon leaves (PL) extract on the toxic effect induced by cadmium chloride (CdCl2) in cultured human skin fibroblasts (Detroit 551). In this study, CdCl2 showed the cytotoxicity by a significant decrease of the cell viability and cell adhesion activity (CAA). While, vitamin E as antioxidant protected CdCl2-induced cytotoxicity by the increase of CAA which was decreased by CdCl2. In the protective effect of PL extract against CdCl2-induced cytotoxicity, PL extract blocked CdCl2-induced cytotoxicity by the a significant increase of CAA as well as superoxide dismutase (SOD)-like activity and inhibitory activity of lipid peroxidation (LP). From these results, it is suggested that the cytotoxicity of CdCl2 is involved in oxidative stress, and PL extract showed the antioxidative effect by showing not only a significant increase of CAA but also SOD-like activity and inhibitory activity of LP. Conclusively, the physioactive components such as PL extract may be a putative beauty resources for the diminution or blocking the cytotoxicity or oxidative stress mediated by heavy metals or chemicals which are the materials of hair dyes or cosmetics.
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보문 : 피부염 유발제인 삼산화크롬(CrO3)으로 손상된 배양 NIH3T3 섬유모세포에 대한 조개나물 추출물의 항산화 효과
정재윤 ( Jai Yun Jung ),오성균 ( Seung Kyun Oh ),박신희 ( Shin Hee Park ),윤미영 ( Mi Young Yoon ),유영월 ( Yeong Wol Yu ),임요섭 ( Yo Sup Rim ),정인주 ( In Ju Jung ) 대한미용학회(구 대한미용과학회) 2014 대한미용학회지 Vol.10 No.1
This study was to evaluate the protective effect of Ajuga multiflora BUNGE(AMB) extract on the cytotoxicity induced by chromium trioxide (CrO3), dermatitis inducer. For this study, the cytotoxicity induced by CrO3 was assessed by colorimetric assay after NIH3T3 fibroblasts were cultured in media containing various concentrations of CrO3. And also, the effect of vitamin E was assessed on the CrO3-induced cytotoxicity. For the protective effect of AMB extract on CrO3- induced cytotoxicity, NIH3T3 fibroblasts were pretreated with 60 or 80 μg/mL of AMB extract for 2 hours, and also, antioxidative effects of ABM extract were analysed via electron donating ability (EDA) and lactate dehydrogenase (LDH) activity. In this study, CrO3 significantly decreased cell viability in a dose-dependent manner, and the XTT50 value was calculated at 28.4 μM. In the effect of vitamin E, it significantly increased cell viability decreased by CrO3-induced cytotoxicity. In the protective effect of AMB extract on CrO3-induced cytotoxicity, it significantly increased cell viability which was decreased by CrO3-induced cytotoxicity, and also it showed EDA and LDH inhibitory activity. From these results, it is suggested that the cytotoxicity of CrO3 is involved in oxidative stress, and also, AMB extract effectively prevented CrO3-induced cytotoxicity by the antioxidative effect. Conclusively, the natural plant component like AMB may be a putative agent for the prevention of the cytotoxicity induced by dermatitis inducer correlated with oxidative stress.
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보문 : 모발염색제 성분인 초산납에 대한 어성초 추출물의 항산화 및 미백효과
정재윤 ( Jai Yun Jung ),오영희 ( Young Hee Oh ),박신희 ( Shin Hee Park ),윤미영 ( Mi Young Yoon ),표애자 ( Ae Ja Pyo ),김선주 ( Sun Ju Kim ),유영월 ( Yeong Wol Yu ),정인주 ( In Ju Jung ) 대한미용학회(구 대한미용과학회) 2014 대한미용학회지 Vol.10 No.2
To evaluate the antioxidative and whitening effects of Houttuynia cordata Thunb (HCT) extract on lead acetate (LA), hair dye component, cell viability was measured by colorimetric assay after NIH3T3 fibroblasts were cultured in media containing various concentrations of LA. And also, the effect of antioxidant, vitamin E on LA-induced cytotoxicity was analysed. For the protective effect of HCT extract on LA-induced cytotoxicity, NIH3T3 fibroblasts were pretreated with 110 or 130 μg/mL of HCT extract for 2 h before the treatment of LA. And also, the antioxidative and melanogenic effects of HCT extract were assessed by superoxide dismutase (SOD)-like activity, total amount of melanin and tyrosinase activity. In this study, LA significantly decreased cell viability in dose-dependent manner. And the XTT50 value was calculated at 48.3 μM of LA. In the effect of antioxidant, vitamin E, it effectively prevented LA-induced cytotoxicity by the significant increase of cell viability. In the protective effect of HCT extract on LA-induced cytotoxicity, HCT extract significantly increased cell viability which was decreased by the cytotoxicity induced by LA, and also it showed the antioxidative effect by SOD-like activity. In the melanogenesis, HCT extract showed the decreased of amount of melanin and tyrosinase activity. From these results, it is suggested that the cytotoxicity of LA is involved in oxidative stress, and HCT extract effectively prevented the cytotoxicity and the melanogenesis induced by LA.
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