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홍삼(紅蔘) 수추출물(水抽出物)이 치매단백질(痴매蛋白質) APP 형질전환(形質轉換) 초파리에 미치는 영향(影響)
김영준 ( Young Jun Kim ),김진형 ( Jin Heong Kim ),윤종현 ( Jong Hyun Yun ),정은영 ( Ejun Young Jung ),김태헌 ( Tae Heon Kim ),유영수 ( Yeoung Su Lyu ),강형원 ( Hyung Won Kang ) 대한한방신경정신과학회 2009 동의신경정신과학회지 Vol.20 No.1
Objectives: Ginseng Radix Rubra water extract(RGE) has been used in vivo test for its beneficial effects on neuronal survival and neuroprotective functions, particularly in connection with APP-related dementias and Alzheimer`s disease (AD). APP derived from proteolytic processing of the β-amyloid precursor protein (APP), including the amyloid-β peptide (Aβ), plays a critical role in the pathogenesis of Alzheimer`s dementia. Methods: We determined that RGE inhibits formation of APP, which are the behavior, and possibly causative, feature of AD. Results and Conclusions: In the cells, RGE significantly activated antiapoptosis and decreased the activity of APP-grim, a key enzyme in the apoptosis cell-signaling cascade. These results suggest that neuronal damage in AD might be due to two factors: a direct APP toxicity and multiple cellular and molecular neuroprotective mechanisms, including attenuation of apoptosis and direct inhibition of APP, underlie the neuroprotective effects of RGE.
틱(Tic) 장애의 한의변증유형 설문지에 대한 신뢰도 및 요인분석 연구
위영만 ( Young Man Wei ),이고은 ( Go Eun Lee ),정송화 ( Song Hwa Jung ),이희경 ( Hee Kyung Lee ),유영수 ( Yeoung Su Lyu ),강형원 ( Hyung Won Kang ) 대한한방신경정신과학회 2012 동의신경정신과학회지 Vol.23 No.1
Objectives : We purposed to objectify the pattern diagnosis of Tic disorders through factor and reliability analysis regarding a pattern identification questionnaire concerning Tic disorders in children. Methods : We chose and studied 144 children who were pattern-diagnosed out of 200 tic disordered children who visited H hospital in Seoul from January 2006 to April 2011. Results : 1. TTD (50%) was the most common type and the occurrence rate in male children was higher(4.76:1). Also, the rate of hospital visits was highest at the age 8(23.6%). 2. In results concering pattern diagnosis, Gan-poong-nae-dong was most frequently diagnosed in 53 patients (36.8%), and Dam-hwa-yo-sin (42 patients), Gan-sin-um-her (30 patients), and Bee-her-gan-wang (6 patients) . 3. In an attempt to verify the reliability of the questionnaire, the coefficient regarding the whole questions (Cronbach α) came to 0.909. Moreover, the reliability coefficient foreach sub factor was 0.687 in Gan- poong-nae-dong, 0.817 in Dam-hwa-yo-sin, 0.851 in Bee-her-gan-wang, and 0.726 in Gan-sin-um-her, respectively. Thus, their consistency was ensured. 4. In exploratory factor analysis concerning the most common five questions in the questionnaire, the questions of Dam-hwa-yo-sin and Gan-poong-nae-dong appeared to be part of different factors. While, Gan-sin-um-her and Bee-her-gan-wang questions showed that they belong to the same factors. 5. In factor analysis excluding both Gan-sin-um-her and Bee-her-gan-wang questions, both showed significant results; however, the one excluding Gan-sin-um-her showed improved results. Conclusions : From the above results concerning the Pattern Identification Questionnaire for Tic Disordered children, three separated patterns of Bee-her-gan-wang, Dam-hwa-yo-sin, Gan-poong-nae-dong are thought to be available for clinical use. However, further validity studies are needed.
한의학 칠정(七情)에 기반을 둔 핵심감정평가척도 개발을 위한 예비 연구
이고은 ( Go Eun Lee ),박보영 ( Bo Young Park ),김향이 ( Hang Yi Kim ),유영수 ( Yeoung Su Lyu ),강형원 ( Hyung Won Kang ) 대한한방신경정신과학회 2014 동의신경정신과학회지 Vol.25 No.1
Objectives: The aim of this study is to investigate the core emotion assessment instrument based on the Chiljeong. Methods: We searched for a literature review of oriental medicine and established the operational definition. Based on the existing psychological scale measurement, we selected the items and analyzed the reliability through a two-step preliminary study. Results: 1) Through the analysis of reliability after the two-step preliminary study (first: 170 items, n=63, second: 152 items, n=42), we had excellent internal consistency (Cronbach``s alpha > 0.70) as well as good test-retest reliability (>0.70). Thus, we demonstrated that this scale had reliability. 2) Analyzing the correlation of each emotion, we had a comparatively strong positive-correlation (>0.6), except for Hui, and found a particularly high correlation of Sa, U and Bi. Conclusions: We developed the final 141 items of the core emotion assessment instrument through the two-time preliminary study. In the future, the main study on the clinical and non clinical groups of various ages should be continued.
박금숙 ( Keum Sook Park ),김영희 ( Young Hee Kim ),이경완 ( Kyoung Wan Lee ),유영수 ( Yeoung Su Lyu ),정헌영 ( Heon Young Jeong ) 대한한방신경정신과학회 2014 동의신경정신과학회지 Vol.26 No.1
Objectives: This study was conducted to analyze the hwa-byung, self-perceived health, life-stress, social support, depression, and factors affecting on suicidal ideation in community dwelling elders. Methods: This study was a cross-sectional descriptive study. The subjects were 165 elderly in I city. The data was collected from November 21st to December 5th of 2014 by using structured questionnaire. T-test, Pearson`s correlation coefficients, and stepwise multiple regression were performed by SPSS/PC 17.0. Results: There were more females than males in hwa-byung (t=..3.068, p=.003). In the visit parent, more than once a month was a significantly higher in social support (t=.3.333, p=.001). Hwa-byung (t=..2.577, p=.011), life-stress (t=..3.800, p=.001), depression (t=..2.776, p=.006), and suicidal ideation (t=..4.316, p£¼.001) were shown to be high in the elders with lower level of living. Subjects with health insurance had high self-perceived health (t=.3.800, p=.001) and low hwa-byung (t=. 4.102, p£¼.001), life-stress (t=.4.482, p£¼.001), depression (t=.5.296, p£¼.001), and suicidal ideation (t=..2.152, p=.036), according to the type of insurance. In the correlation, sleeping hours (r=..180, p=.020), self-perceived health (r=..364, p£¼.001), and suicidal ideation had negative correlation; hwa-byung (r=.404, p£¼.001), life-stress (r=.300, p£¼.001), social support (r=..310, p£¼.001), depression (r=.423, p£¼.001) and suicidal ideation had positive correlation. Factors affecting the suicidal ideation in community dwelling elders were depression (¥a=.42, p£¼.001), hwa-byung (¥a=.23, p=.004), social support (¥a=..18, p=.012), and level of living (¥a=.24, p=.001). Discussion: For the prevention of elderly suicide, it is necessary to care for psychosocial status and solve economic difficulties through social support.
불면증 환자에 대한 침치료 전후 정량화 뇌파 분석: Z Scored Absolute Power and sLORETA
이고은 ( Go Eun Lee ),문수정 ( Su Jeong Mun ),이성익 ( Sung Ik Lee ),임정화 ( Jung Hwa Lim ),위영만 ( Young Man We ),문광수 ( Kwang Su Moon ),유영수 ( Yeoung Su Lyu ),강형원 ( Hyung Won Kang ) 대한한방신경정신과학회 2016 동의신경정신과학회지 Vol.27 No.3
Objectives: To investigate the neurophysiological effect of acupuncture treatment on insomnia patients using quantitative electroencephalography (QEEG) and standardized Low Resolution Brain Electromagnetic Tomography method (sLORETA). Background: Insomnia is one of the commonly encountered symptoms in primary medical care. Recent studies of acupuncture for insomnia reported that the acupuncture groups showed significant improvements compared with the control groups. However, the neurophysiological mechanism of acupuncture in the treatment of insomnia has not been revealed and a few studies have measured the effect of acupuncture treatment using QEEG. Methods: Participants who had some problems in initiating or maintaining sleep, or had non-restorative sleep for more than 3 days a week and ISI scores above 8 and below 21 were treated by acupuncture for 2 weeks (3 times a week, total 6 times). We assessed the effectiveness of acupuncture for insomnia by the PSQI (Pittsburgh Sleep Quality Index) at baseline and at 2 weeks after the end of treatment (4th week). Also, we performed EEG and analysed the EEG data at baseline and at the end of treatment (2nd week) on the linked ears montage using the Neuroguide software program and sLORETA. Results: Thirty-two participants were enrolled and 2 participants dropped out because of personal reasons. Among the 30 participants, EEGs of 12 participants were included in the analysis of QEEG and sLORETA. Total score on the ISI and PSQI was significantly decreased after acupuncture treatment. The number of electrodes exceeding the range of 90% (±1.65) or 95% (±1.96) in the z scored absolute power of beta was significantly decreased after acupuncture treatment. There was no significant change in brain activation between pre- and post-acupuncture using sLORETA. Conclusions: The deviation of absolute power compared to the normative database was significantly decreased after acupuncture treatment in the alpha and beta ranges. Therefore, we suggest that acupuncture treatment for insomnia might be effective through the central nervous system especially in the brain. There are many limitations to drawing any conclusion. Further studies are needed in the future to overcome these limitations.
柳泳秀 圓光大學校 韓醫學硏究所 1995 원광한의학 Vol.5 No.1
From the consequence of the eastern and western medical research in stasis symptom complex(鬱證) from the view of psychiatry, this paper could get the followings: 1) From the view of psychiatry, stasis symptom complex(鬱證) can be understood as pathology of stagnation of Qi(氣) by excessive affection. 2) Affective staiis(情志之鬱) acts as the cause of disease on the aspect of intensity, time of simulation, and the weakness of visceral vital energy(臟氣弱) with the pathetic cause unable to emit. 3) Affective stasis, pathologic change of Qi(氣) in body, appears at first as excessiveness symptom complex(實證) of the stasis of liver vital energy(肝氣鬱結). If being prolonged, it appear as all deficiency symptom complex(虛證) of five visceral such as Qi stasis by blood deficiency(氣鬱血虛). 4) The pain caused by stasis symptom complex is tought to involve both meaning that being cut off one became sick(不通則痛), not being managed one became sick(不營則痛), and especially it involves the goal of secondary advantage in the pain caused by mind. 5) Though nervous disorder(火病) means a part of the changing process of stasis symptom complex, it means of symbolic disorder. 6) Stasis symptom complex, declined to the cause of disease and pathology, leads the meaning of symptom in Oriental medicine, but it is primarily limited to the mental symptom in Western medicine. 7) Stasis symptom complex corresponds to the theory of stress on the aspect of the cause of disease and pathology, and that it must be more profoundly studied on the aspect of disorder.