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RISS 인기검색어
- 검색키워드
- 저자 : 우상준(Sang Joon Woo) (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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유원상(Won Sang Yoo),우상준(Sang Joon Woo),성영주(Yong Joo Seong),김준희(Joon Hee Kim),최석구(Suck Koo Choi),전영빈(Young Bin Jeon) 대한내과학회 1991 대한내과학회지 Vol.41 No.2
N/A Thirty four patients with essential hypertension, who could successfully discontinued antihypertensive drug treatment, were analyzed to find out the clinical indices which can be used for the prediction of success and duration of the drug withdrawal. The resnets were as follows: 1) The shorter the time for the normalization of blood pressure after drug administration, the longer the duration of drug withdrawal and the lower the rate of remedication. 2) The duration of withdrawal was inversely proportional to the level of pretreatment mean arterial pressure, the duration from the beginning of drug administration to the withdrawal, and the duration from the time when the blood pressure was normalized to the time when the antihypertensive medicines were withdrawn. 3) There was no correlation between the existence of cardiac complications of hypertension and the duration of successful withdrawal. 4) The rate of remedication of antihypertensive medicines among the patients who had stopped taking the medicines was 53%. In conclusion, among the hypertensive patients, if a persons blood pressure could be normalized within 3 months after the beginning of medication, he would be a good candidate for drug withdrawal. In other cases, if the dosages of antihypertensive medicines could be tapered off at the sixth month and taking the medicines could be stopped at the 12-18th month, the duration of drug withdrawal could be 9-18 months.
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Kim, Chul Soo,Kim, Joon Hee,Cho, Byung Ryul,Lee, Sung Bong,Han, Sang Won,Sohn, Young Don,Woo, Sang Jun,Jeon, Young Bin,Kim, Sung Rok,Kim, Re Hwe 인제대학교 1991 仁濟醫學 Vol.12 No.1
최근 Etoposide를 포함한 복합 화학요법이 위암에 대해 높은 반응을 보인다는 몇가지 보고가 있었다. 저자들은 진행성이며 수술이 불가능했던, 흑은 재발한 위암 환자를 대상으로 Mitomycin-C (6mg/m2, IV, 제1일), Cisplatin (60mg/m2, IV, 제2일) 과 Etoposide (60mg/m2, IV, 제3일)의 복합 화학요법을 매 4주 마다 실시하여 이들병합 화학요법의 독성 및 항암효과에 대하여 조사하였다. 1989년 10월부터 1990년 8월까지 27명(남자 : 여자=19 : 8, 나이 31-71세, 중앙치 56세)의 환자가 대상이 되었다. 이들중 5명은 치료도중 추척관찰이 불가능 하여 나머지 22명의 평가만이 가능하였다. 환자의 작업능력 (Performance status)은 ECOG (Eastern Cooperative Oncology Group) 기준상 5명 (1명은 2였고 4명은 3이 었다)을 제 외하고는 모두 1이었다. 7명은 이전에 다른 종류의 항암요법을 시행받은 경험이 있었다. 치료는 1회에서 6회, 평균 2회 실시하였다. 9명은 위장관독성이 심하여 치료가 필요하였다. 10명은 중등도의 오심과 구토를 경험하였으며 3명만이 증상이 경미하였다. 모든 환자에서 어느정도의 탈모증은 있었고 8명에서는 치료회수가 많아짐에 따라 완전탈모증이 관찰되었다. 화학요법과 관련된 출혈 및 발열은 없었다. 치료후 12일과 21일 사이에 10명의 환자에서 3,000/ul이하의 백혈구 감소증이 있었고 그중 제일 낮았던 사람은 1,400/ul이었다. 2명에서 100,00/ul이하의 혈소판감소증이 있었고 그중 제일 낮았던 사람은 63,000/ul이었다. 백혈구와 혈소판의 숫자는 28일째에 모두 정상으로 회복되었다. 7명(32%)에서는 객관적인 반응(Objective response)이 있었으나 완전관해는 없었다 관해 기간과 생존기간은 측정하지 않았다. Recently, several reports claimed that etoposide containing polychemotherapies produced hiugher response rates in gastric cancer. We treated advanced inoperable or recurrent gastric cancer patients with mitomycin-C(6mg/sq m IV on day 1), cisplatin (60mg/sq m IV on day 2), and etoposide (60mg/sq m IV on days 3,4, and 5) in combination every four weeks to assess toxicities and anti-tumor activity of the regimen. From October 1989 through August 1990, 27 patients (M:F= 19:8, ages ranging 31-71 with median of 56) were accrued for our study. Five patients were lost to follow-up; 22 patients were evaluable. The performance status of the patients were mostly in ECOG grade 1 except for five patients, one in 2, four in 3. Seven patients had been previously exposed to other regimens. The courses of treatment given ranged 1-6 with median of 2 cycles. Gastrointestinal toxicities were so severe that 9 patients required treatment. Ten patients suffered from moderate degree of nausea and vomiting and only three could go on with minimal symptoms. Alopecia occurred in all patients to some extent; eight patients had complete alopecia as cycles were added. There was no febrile or bleeding episode related to the chemotherapy; ten patients had leukopenia below 3X103/uL with the lowest of 1.4X103/uL, two had thrombocytopenia below 100X103/uL with the lowest of 63X103/uL between day 12 and 21, WBC and platelet counts returned to normal in all patients on day 28. Seven patients (32%) showed objective responses. none of them completely. The durations of response and survival were not measured.
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