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감초(Glycyrrhiza uralensis Fisch.)로부터 분리된 flavonoid의 인체 암세포에 대한 세포독성
박지해 ( Ji Hae Park ),우치엔 ( Qian Wu ),유기현 ( Ki Hyun Yoo ),용혜임 ( Hye Im Yong ),조승목 ( Sueng Mock Cho ),정인식 ( In Sik Chung ),백남인 ( Nam In Baek ) 한국응용생명화학회(구 한국농화학회) 2011 Journal of Applied Biological Chemistry (J. Appl. Vol.54 No.1
The roots of Glycyrrhiza uralensis Fisch. were extracted with 30% aqueous ethanol (EtOH), and the concentrated extract was partitioned with n-hexane, chloroform (CHCl3), ethyl acetate (EtOAc), n-butanol (n-BuOH), and H2O, successively. From the CHCl3 fraction, four flavonoids were isolated through the repeated silica gel (SiO2), octadecyl silica gel (ODS), and Sephadex LH-20 column chromatographies (c.c.). According to the results of spectroscopic data including nuclear magnetic resonance spectrometry (NMR), electron ionization mass spectrometry (EI/MS), and infrared spectroscopy (IR), the chemical structures of the compounds were determined as glabrol (1), abyssinone II (2), glabridin (3), and isoliquiritigenin (4). The flavonoids were evaluated for cytotoxic effect against human cancer cell lines, HCT-116, HepG2, HeLa, SK-OV-3, SK-BR-3, MCF-7, and SK-MEL-5. Especially, glabrol (1) and glabridin (2) showed IC50 values of lower than 25 μM.
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glutamate 수용체 효현제 투여에 의한 cathepsin D 함유 신경원의 발현
김호정,용혜임,김현 관동대학교 의과대학 의과학연구소 2005 關東醫大學術誌 Vol.9 No.1
Glutamate, one of the excitatory amino acids (EAAs), in a large amount causes neuronal injury. Recently EAAs are believed to play an important role in various kinds of neurologic diseases. Cathepsin D(CD) expression has been reported to be an useful landmark for the excitotoxic insult. Many evidences showed that neurons in hippocampus expressed CD as a result of excitotoxicity. But we have no idea whether any neurons in other regions of the brain express CD by excitotoxic injury. The research was designed to search for any neurons which would express CD when treated with excitotoxins. Kainic acid, an agonist for the glutamate ionotropic receptor, was injected intracerebroventricularly with a Hamilton syringe using a stereotaxic surgical instrument. After 4, 24 and 48 hours of injection the tissues of hippocampal region were processed. Routine histological stain and immunohistochemical stain against CD were carried out. CD-positive cells were examined and their immunoreactive properties and exact location in the brain were identified. The results were as follows; 1. The hippocampal neurons showed immunoreactivity against CD as early as 4 hours of treatment. Their immunoreactivity continued from 4 hours to 48 hours. 2. The neurons of some hypothalamic nucleus showed immunoreactivity against CD in different ways. Neurons of the periventricular nucleus expressed CD only at 4 hours, while those of the dorsomedial nucleus expressed at 24 hours, and those of the supraoptic nucleus expressed from 4 hours through 24 hours. 3. The neurons of the subthalamic nucleus and the substantia nigra expressed CD only at 4 hours. For the expression patterns of CD were variable according to the regions, the cell types, and the time segments measured, it would be helpful to make the time segment of the examination smaller to recognize the exact expression pattern of CD.
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