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Singapore시민 및 집쥐의 신증후출혈열 병원체에 대한 혈청역학적 조사
이호왕,유상렬,백락주,주용규,왕제와이,찬유정 대한바이러스학회 1991 Journal of Bacteriology and Virology Vol.21 No.1
Korean hemorrhagic fever (KHF) came to the attention of Western medicine during the Korean War when it was a major source of morbidity and mortality among the United Nations troops in Korea. Clinically similar diseases to KHF have been known for several decades under different narnes in many regions of Euro-Asia continent. In 1982, the World Health Organization adopted the term Hemorrhagic fever with renal syndrome (HFRS) to designate KHF and other diseases with compatible clinical syndrome. The causative agent of KHF was first isolated in 1976 from the rodent Apodemus agrarius and in 1978 frorn patients sera from KHF by Lee and Lee. The agent was named Hantaan virus after Hantaan river in 1981 and also discovered another agent similar to Hantaan virus in house rat captured in Seoul city and named it Seoul virus. Geographically HFRS is sporadically epidemic throughout the Euro-Asia continent. HFRS has not been reported yet in tropical areas such as Singapore and Malaysia. Recent seroepidemiologic surveys show that agents antigenically similar to Hantaan virus are widely distributed throughout rnuch of the world, to a much greater geographic extent than previously recognized. This study was conducted for seroepidemiologic survey of sera from residents, laboratory rats and urban rats against the etiologic agent of HFRS in Singapore. The results are as follows : 1. 8 out of 261 patients of suspected Leptospirosis exhibit seropositive against Hantaan and Seoul viruses and one case was confirmed as HFRS patient. 4 out of 176 acute nephritis patients exhibit seropositive against Hantaan virus. 2. 143 (43.3%) out of 330 laboratory rats in Singapore University had antibodies to Hantaan virus, but 26 research workers who had worked in this laboratory showed seronegative. 3. 14 (24.6% ) out of 57 urban rats in Singapore city showed seropositive against Hantaan virus. Among 66 rats lungs were examined, one was found to have massive viral antigen in lung tissues. The above results indicate for the first time that virus similar to Hantaan virus or Seoul virus was distributed in house rats and laboratory rats in Singapore, and the possibility of existence of many HFRS patients in Singapore.
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