http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
왕소영(So-Young Wang),최환수(Whan-Soo Choi),김용진(Yong-Jin Kim) 한국의사학회 2003 한국의사학회지 Vol.16 No.1
The GyoJungEuiSeoGook(校定醫書局, the bureau for revising of medical books) which was established in the 2nd year of InJong GaWoou of Song dynasty, made comparative analyzation about various kinds of publication and reference materials of all classical medical books that was published until Jin Han and Su Dang dynasty, revised the medical books like as Bozushinnongboncho(補注神農本草), Zungkwangbozuhwangjenegyungsomun(重廣補注黃帝內經素問), Shanghanlon(傷寒論), Bigupchunggumyobang (備急千金要方), Magkyung(脈經), Oedaebiyo(外臺備要), Hwangjechimgugapeulgyung(黃帝鍼灸甲乙經), Cchunggumikbang(千金翼方) etc. The signification of such revision was not only to preserve the materials which may be lost before, bibliographically and also make the books of Hwangjenegyung(黃帝內經), Shanghanlon(傷寒論) etc. become more regularly. And it made the foundation of Korean Medical research depends on the documentary records so as to make it have big development by deductive method till the beginning of modern age. The success of GyoJungEuiSeoGook(校定醫書局) indicates that the stagnation of Korean Medical research due to it’s behind with the development of politics-economy, social culture and scientific technology which based on western scientific culture. So we may draw the conclusion that the success of scientific research needs to parallel with the external and internal factors of the surrounding science.
Kim Yong-jin(金容辰),Wang So-young(王昭迎) 한국의사학회 2000 한국의사학회지 Vol.13 No.1
Through this research, it was discovered that Wang Sa-wung studied classics such as 『Nai Kyung』, and brought about new theries and prescription by combining it with his own experience. He asserted ‘Ki Hwa Chu Ki’ theory which differentiated ‘Shin Kam’ and ‘Bok Sa’ within ‘On Byung’, and this was a new theory which was not in existence before. The main reason for the recognition received by the future generation is, not only because of the substantial theoretical background but, due to the fact that his ideas were based on making practical use easier within rich near a bed experience.
박인숙,김동섭,최기환,왕소영,임화경,오우용,김소희,강주희,방영주,김주일,Park, In-Sook,Kim, Dong-Seop,Choi, Ki-Hwan,Wang, So-Young,Lim, Hwa-Kyung,Oh, Woo-Young,Kim, So-Hee,Kang, Ju-Hee,Bang, Yung-Jue,Kim, Joo-Il 대한임상약리학회 2002 臨床藥理學會誌 Vol.10 No.2
The enormous cost, intensive time, and constant efforts are required the drug discovery and development of bringing new drug products to the marketplace. The past several years, KFDA approved new drugs developed by local pharmaceutical industries; that is Sunppla, Factive etc. In addition to, investigational new drug application (IND) was established to accelerate new drug development and harmonize with international standards in 2002. At this point of time it is urgent problem to develop ability of reviewing new drug applications (NDAs) scientifically and appropriately to ensure that new drugs are safe and effective. There are many scientific issues embedded in new drug approval process from non-clinical studies to phase 3 clinical trials; 1) sample size, 2) application of end point, 3) statistical method, and etc. However the overall relation between protocols/reports of clinical trials and the characteristics of domestic medical system has fully not been studied. There is also, no references or data for the point to be considered in drug approval process. On this background, the objectives of this study are introduction of guidelines for the requirement for approval or evaluation of safety/efficacy in other countries and presentation how to practice clinical trial for new oncologic products in the present situation of clinical trial. We hope that the guidelines contribute to providing methods of clinical trials and procedures, and evaluating method to develop chemotherapeutic agents.
Nalbuphie의 병용투여에 의한 morphine의 내성 및 의존성 헝성 저하효과
정면우(Myeon Won Chung),임화경(Hwa Kyung Lim),전용준(Yong Joon Jeon),김혜정(Hye Jung Kim),박인숙(In Sook Park),오우용(Woo Yong Oh),왕소영(So Young Wang),박윤주(Yoonju Park),강주희(Ju Hee Kang),김동섭(Dong Sup Kim),김주일(Joo Il Kim) 대한약학회 2002 약학회지 Vol.46 No.4
Morphine has been used widely on the treatment of many types of chronic pain. However the development of tolerance to morphine by repeat application is a major problem in pain therapy: The purpose of the present study was to investigate whether combined administration of nalbuphine with morphine affects the development of tolerance to and dependence on morphine. We hypothesize that the use of nalbuphine, k-agonist may prove to be useful adjunct therapy to prevent morphine-induced undesirable effects in the management of some forms of chronic pain. Morphine (10 mg/kg) was injected to rats intraperitoneally for 5 days. The variable dose of nalbuphine (0.1,1.0 and 5.0 mg/kg) was administered (I.p.) in combination with morphine injection. The development of tolerance to morphine was assessed by measuring the antinociceptive effect with the Randall-Selitto apparatus. The development of dependence on morphine was determined by the scoring the precipitated withdrawal signs for 20 min after injection of naloxone (10 mg/kg,I.p.). Nalbuphine did not attenuate antinociceptive effect of mofhine in rats. Interesting1y; combined administration of morphine with nalbuphine (100:1) sign- nifcantly attenuated the development of morphine tolerance and dependence. These results suggest that the co-admin-istration of nalbuphine with morphine in chronic morphine treatment can be one of therapies to reduce the development of dependence on morphine.