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대식세포에서 폐렴구균 협막 다당류에 의한 TNF-α 및 Nitric Oxide 생성
엄성희(Sung Hee Um),엄진섭(Jin Sub Um),인상환(Sang Hwan In),문은이(Eun Yi Moon),이동권(Dong Kwon Rhee),표석능(Suhk Neung Pyo) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.1
Capsular polysaccharides (CPs) from Streptococcus pneumoniae were examined for the ability to induce secrefory responses in a pure population of peritoneal macrophages. The highly purified CPs were able to affect the macrophage, ie, secretion of tumor necrosis factor-alpha(TNF-α) and nitrite. As after stimulation with CPs, secretion of TNF-αinduced by these CPs reached its maximum within the first few hours of the interaction, while secretion of nitrite was increased with time. In addition, production of TNF-αand nitrite was increased in a dose-dependent manner. In the presence of indomethacin, CP-stimulated TNF-αproduction was not altered. In contrast, LPS with indomethacin stimulated 24.5% more TNF-αthan LPS alone, suggesting that the intracellular signaling processes for TNF production are differentially stimulated by CP and LPS. The results demonstrate that CPs are potent inducer of macrophage secretory activities.
엄성희 ( Sung Hee Um ),오지원 ( Chee Won Oh ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.1
Clear cell acanthoma is a relatively uncommon benign disease, which usually presents as solitary lesions, often localized on the lower legs of middle aged or elderly individualsl. Clinically it presents as a flat or dome-shaped, sharply demarcated papule
Acitretin 치료로 호전된 비호지킨 림프종과 병발한 사마귀양 표피이형성증 1 예
허은필(Eun Phil Heo),엄성희(Sung Hee Um),오지원(Chee Won Oh) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.8
Epidermodysplasia verruciformis(EV) is a rare disease characterized by a unique susceptibility to widespread infection with human papilloma virus. It induces flat papular skin lesions, characterized by large vacuolated cells in the upper epithelial layers. We report a patient of EV in association with non-Hodgkins lymphoma(NHL) improved with systemic acitretin treatment. A 69-year-old man presented multiple red flat-topped papules and plaques on his face and upper extremities for 12 years. Past various therapeutic modalities including DPCP sensitization were entirely ineffective. Several years ago, NHL of cervical lymph node was diagnosed. With the treatments with chemotherapy and radiotherapy, he is now in remission state. His skin biopsy specimen showed extensive vacuolation of upper malpighian layer. Bleomycin IL trial showed no response. Only 1 week after oral acitretin administration, his lesions began to exfoliate and became much flatter. Acitretin was effective but not suitable for maintenance therapy.
대식세포에서 국산약용식물의 항암 및 항Virus 에 대한 효과
표석능(Suhkneung Pyo),지옥표(Ok Pyo Zee),엄성희(Sung Hee Um),김대근(Dae Keun Kim),곽종환(Jong Whan Kwak),이강노(Kang Ro Lee),이동권(Dong Kwon Rhee) 한국생약학회 1995 생약학회지 Vol.26 No.3
In the present work, 70 extracts from 23 plants have been determined to induce cytotoxic and antiviral activities of macrophages using both MTT assay and neutral red dye uptake assay. We show that 13 extracts have induced cytotoxic activities and 5 extracts induced antiviral activity in mouse peritoneal macrophages. Among 13 extracts, macrophages treated with extracts from Salvia plebeia have demonstrated significant cytotoxicity but not antiviral activity. The present findings indicate that extracts from plants can stimulate macrophages to become resistant to virus and to kill tumor cells.
엄성희,오지원 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.10
Verrucous hemangiomas are usually congenital lesions which typically present as warty, bluish, vascular papules, plaques, or nodules mainly on the lower limbs of children. It is a structural variant of capillary or cavernous hemangioma, in which reactive epidermal changes develop secondarily. They show no tendency to spontaneous resolution, and tend to spread and recur after inadequate treatments. It is important, from a prognostic and therapeutic point of view, to make a correct diagnosis between verrucous hemangioma and angiokeratoma circumscriptum, because the former needs a large and deep excision and the latter responds to the common means of physical therapy. We report a case of 37-year-old man with verrucous hemangioma which was developed at his third decade.(Korean J Dermatol 2003;41(10) : 1390~1393)