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이현주 ( Hyun Joo Lee ),신현찬 ( Hyun Chan Shin ),정희웅 ( Hee Woong Jeong ),정철권 ( Chul Gwon Chung ),권민정 ( Min Jeong Gwon ),엄상탁 ( Sang Tag Eum ),박경도 ( Kyung Do Park ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.6
목적 : 본원에서 비정상적 자궁내막 소견을 보이는 환자를 대상으로 자궁 절제경을 시행하여, 그 치료효과, 임신 성공률, 그리고 진단된 절제경 및 병리학적 소견에 대해 조사하였다. 연구 방법 : 1995년 5월부터 2000년 12월까지 불임증, 비정상적 자궁출혈 및 월경과다를 주소로 내원한 환자 중 비정상적 자궁내막소견을 보인 110명 환자를 대상으로 하였다. 비정상적 자궁내막 소견을 보인 불임환자와 비정상적 자궁출혈 환자는 자궁절제경 수술을 시행하였고, Objective : The purpose of our study is to find out the therapeutic effectiveness, reproductive outcome, and the diagnostic pathologic findings of the patients treated with resectoscopy. Methods : We examined 110 patients who complained infertility, abnor
오성희,배덕수,노정수,최세미,엄상탁,박창수,이제호 대한부인종양 콜포스코피학회 1999 Journal of Gynecologic Oncology Vol.10 No.3
Malignant mixed mu¨llerian tumors(MMMTs) are uncommon neoplasms of the female genital tract that are histologically defined by the presence of malignant epithelial and stromal elements. MMMTs can arise hom the uterine body, cervix, vagina, ovary, and fallopian tube and constitute less than 1% of all overian malignancies. These tumors are usually advanced when diagnosed and follow an aggressive clinical course. We had experienced a case of MMMT of the ovary and presented with a brief review of literature.
자궁 경부 암에서 유식세포분석에 의한 DNA 양상과 임상적 특성과의 상관관계
강선영,배덕수,엄상탁,박창수,이제호 대한부인종양 콜포스코피학회 1999 Journal of Gynecologic Oncology Vol.10 No.4
Objective: Flow cytometric deoxyribonucleic acid (DNA) content analysis has been shown to be of prognostic importance in some cancers. In this study, DNA patterns obtained by flow cytometry in patients with cervical cancer have been shown to be related to a prognostic importance in cervical carcinoma. Methods And Materials: We retrospectively reviewed 59 cervical cancer patients who admitted to the department of obstetrics and gynecology, Samsung Medical Center from January 1995 to May 1997. Results: A total of 59 archival paraffin-embedded blocks were proc 42.4 percent were found to be DNA content aneuploid (DNA-A) and 57.6 percent DNA content diploid (DNA-D). The S-phase fraction was significantly increased with stage. The incidences of aneuploid and relative DNA index were not significantly increased with the stage(P=0.280) and age of patients(P=0.088). The results had no significant differences between the squamous cell carcinoma and adenocarcinoma, and no relationship between the groups with keratinizing cell type and nonkeratinizing type(P=0.409). The DNA ploidy patterns were not significantly correlated with metastasis to lymph node(P=0.179), tumor size(P=0.109), invasion depth(P=0.361) and recurrent group(P=0.285). High S-phase fraction had a tendency to correlate with the invasion depth(P=0.011), size(P=0.027), lymph node metastasis(P=0.039) and recurence(P=0.099) of cervical cancer. Conclusion: Flow cytometric DNA content analysis is being used more frequently in the management of different malignant tumors. Our study shows that DNA content analysis may not serve as an important biological indicator in determining the prognosis in cervical carcinoma, but High S-phase fraction has been connected with more aggressive tumors.