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칼슘 및 칼슘이온통로 차단제가 흰쥐 척수후각세포의 반응에 미치는 영향
엄민숙,신홍기,김진혁,김기순 한양대학교 의과대학 1998 한양의대 학술지 Vol.18 No.2
Calcium ions are implicated in a variety of physiological functions, including enzyme activity, membrane escitability, neurotransmitter release, and synaptic transmission, etc. Calcium antagonists have been known to be effective for the treatment of exertional angina and essential hypertension. Selective and nonselective voltage-dependent calcium channel blockers also have inhibitory action on the acute and tonic pain behaviors resulting from thermal stimulation, subcutaneous formalin injection and nerve injury. This study was undertaken to investigate effects of the iontophoretically applied Ca^2+ and its antagonists on the responses of wide dynamic range (WDR) cells to sensory inputs. The responses of WDR cells to graded electrical stimulation of afferent nerve and also to thermal stimulation of the receptive field were recorded before and after iontophoretical application of Ca^2+, EGTA, Mn^2+, verapamil, w-conotoxin GVIA, and w-conotoxin MVIIC. Also studied were the effects of calcium channel antagonists on the tonic pain responses of WDR cell to subcutaneously injected formalin into the receptive field. Iontophoretically applied Ca^2+ and calcium channel antagonists (Mn^2+, verapamil, & w-conotoxin GVIA) suppressed the C-fiber and thermal responses of WDR cell without any significant effects on the A-fiber responses. w-Conotoxin MVIIC did not have any significant inhibitory actions on A-fiber, C-fiber and thermal responses of WDR cells. Iontophoretical application of EGTA augmented the thermal responses of WDR cells, which were inhibited by Mn^2+. When EGTA(15mM) was applied onto the spinal cord, the C-fiber responses were augmented until 5-10min after spinal application of EGTA but thereafter the responses gradually declined. In less than 20% of WDR cells, subcutaneous injection of formalin induced biphasic pain behaviors which were very weak and irregular. Therefore, it was concluded that the formalin-injected rats were not an ideal animal model for this short of study. These findings suggest that activation of L- and N- type calcium channels can greatly influence the transmission of sensory signals at the spinal neurons.
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강석한,김찬,엄민숙,김진혁,김기순 한양대학교 의과대학 1997 한양의대 학술지 Vol.17 No.1
Peripheral nerve injuries have been known to result in a chronic neuropathic pain characterized by symptoms of spontaneous burning pain, hyperalgesia, and allodynia. Recently it has been reported that the flexor reflex was greatly enhanced immediately after peripheral nerve section in the experimental animals. The persent study was underaken to investigte acute effects of the peripheral nerve injury on the sensitization of dorsal hom cells. After the sciatic nerve section, neither significant change was observed in the wind-up of WDR cells, nor wind-up was produced in the WDR cell that had not shown wind-up before the afferent nerve section. The A-fiber responses of WDR cells were not altered after section of the sciatic nerve. However, the C-fiber responses and after-discharge of the dorsal horn cell to imput signals started to increase in 2 hours after the nerve section. In 70% of experimental animals, the nerve section-induced increments in the WDR cell activities were abolished after topical application of 2% lidocaine to the proximal end of cut sciatic nerve. After pretreatemnt of the experimental animals with a NMDA receptor blocker, MK-801, the C-fiber response and after-discharge of the dorsal horn cell well not changed by the sciatic nerve section. These findings suggest that peripheral injury induces the sensitization of dorsal horn cells of the spinal cord and that signals from the proximal stump is essential for maintenance of the sensitization, which was mediated by NMDA receptors.
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