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유동층 과립 제조기를 이용한 여러가지 유입공기온도와 코팅액 분사속도로 제조된 아세트산아미노펜 마이크로캅셀의 평가
민신홍(Shin Hong Min),양중익(Joong Ik Yang),김근혁(Keun Hyeok Kim),정구충(Gu Choong Jheong) 한국약제학회 1986 Journal of Pharmaceutical Investigation Vol.16 No.4
Microencapsulated acetaminophen granule was prepared in a fluid bed granulator, using ethylcellulose as coating material. We studied the effect of two important control factors, inlet air temperature and liquid flow rate. To evaluate various acetaminophen granules which were prepared by different conditions (inlet air temperature; 40℃, 50℃, 60℃, liquid flow rate; 18㎖, 36㎖, 54㎖, 72㎖/min), we used scanning electron microscope, dissolution tester, sieve analyzer and bulk densitometer. From above results, it was found that at inlet air temperature 50℃ and liquid flow rate 54 ㎖/min we could obtain a smooth and continuous granule surface, a narrower granule size distribution and 90% dissolution time 30-40min.