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Dynamic Light Scattering Method 를 이용한 수중유형 Microemulsion 의 제조조건 평가
민신홍(Shin Hong Min),양중익(Joong Ik Yang),권종원(Jong Won Kwon),정대식(Dae Sik Jeong),정엽(Yeoub Jeong) 한국약제학회 1986 Journal of Pharmaceutical Investigation Vol.16 No.4
O/W microemulsion containing soybean oil and egg phosphatide was prepared by vacuum high shear mixing and high pressure homogenizing. The laser particle sizer, Coulter counter and photomicroscope were used to determine the particle size distribution at each cycle of homogenizer. Particularly, the laser particle sizer(dynamic light scattering method) was applied to the study of particle size distribution behavior below 1㎛. It was found that the particle size distribution below 1㎛ was shifted to lower size range as the number of passing cycle was increased. But, beyond the 7th cycle, the particle size distribution was not varied.
정명화,정엽,정대식,권종원,양중익,민신홍,Chung, Myung-Hwa,Jheong, Yeoub,Jheong, Dae-Sik,Kwon, Jong-Won,Yang, Joong-Ik,Min, Shin-Hong 한국약제학회 1988 Journal of Pharmaceutical Investigation Vol.18 No.1
Physicochemical properties of oil in water microemulsions containing soybean oil and egg phosphatide were observed for 3 weeks under the storage condition of $4^{\circ}C$ refrigerator. Changes in major fatty acid content, particle size distribution, rheogram, acid value and pH value were measured by gas chromatograph, laser particle sizer, Coulter counter and rheometer. From above experiments following conclusions were obtained; 1) Mean particle diameter was shifted from 240 to 266mm. 2) No significant changes were observed in the content of major fatty acids of soybean oil, rheogram, acid value and pH value.
압축코팅법에 의한 3단계 약물방출형 지속성제제의 제조 및 용출특성
김철수,권혁노,차봉진,권종원,양중익,민신홍,Kim, Cheol-Soo,Kwon, Hyeok-Lo,Cha, Bong-Jin,Kwon, Jong-Won,Yang, Joong-Ik,Min, Shin-Hong 한국약제학회 1992 Journal of Pharmaceutical Investigation Vol.22 No.2
A novel oral controlled release tablet which may offer more uniform drug level in the body than simple zero-order was developed. The tablet is composed of three layers; outer film layer, middle part compression-coated hydroxypropylmethylcellulose (HPMC) matrix layer, and inner core layer. Each layer contains nicardipine HCl as a model drug. In vitro dissolution test showed that the tablet released the drug in clear three steps; a rapid initial release, followed by a constant rate of release, and then a second phase of fast release of drug. The dissolution characteristics could be modified easily by changing the grade of HPMC, thickness of matrix layer, content of methylcellulose in matrix layer, content of active ingredient in each layer. The pH of dissolution medium did not affect the release profile. This three-step release system is expected to raise the blood concentration rapidly to effective level and to maintain effective blood level longer than simple slow-release systems.
효소반응법을 이용한 우황 및 우황함유 액상 제제 중 총담즙산의 정량
하인식,김승환,차봉진,권종원,양중익,민신홍,Ha, In-Sik,Kim, Seung-Hwan,Cha, Bong-Jin,Kwon, Jong-Won,Yang, Joong-Ik,Min, Shin-Hong 한국약제학회 1991 Journal of Pharmaceutical Investigation Vol.21 No.2
A simple and sensitive method was developed for the quantification of free and conjugated bile acids in bezoar without prior hydrolysis. $3{\alpha}-Hydroxy$ bile acids are first oxidized to 3-keto bile acids in the reaction catalyzed by $3{\alpha}-hydroxysteroid$ $dehydrogenase(3{\alpha}-HSD)$. During this oxidative reaction, an equimolar quantity of nicotinamide adenine dinucleotide(NAD) is reduced to NADH and subsequently oxidized to NAD with concomitant reduction of nitrotetrazolium blue(NTB) to diformazan by the catalytic action of diaphorase. The diformazan has an absorbance maximum at 540 nm. The intensity of the color produced is directly proportional to bile acids concentration in the bezoar extracts. The optimum conditions for the enzymatic reaction such as effects of reaction time, reaction temperature and pH, and stability were investigated. Calibration plots for the sodium chelate observed to be linear and intra-, inter-assay analytical recovery of bile acids averaged $97.65{\pm}3.4%(S.D.)$. Therefore, it is considered that the quality control of total bile acids from bezoar or bezoar-containing liquid preparation using this simple and sensitive assay system will be acceptable. Also current bezoars and bezoar-containing liauid preparations were examined their total bile acids from this method.
사염화탄소 용액중에서 Thiopropionamide 와 N , N- dimethylacetamide 간의 수소결합에 관한 분광학적 연구
김병철(Byung Chul Kim),양중익(Joong Ik Yang),민신홍(Shin Hong Min) 한국약제학회 1986 Journal of Pharmaceutical Investigation Vol.16 No.4
Near-IR spectra have been obtained for the v₃ + amide II combination band of thioacetamide in CCl₄ and DMA-CCl₄ in the range of 5˚ to 55˚ C. The combination bands of monomeric thiopropionamide (TP) and 1 : 1 complex with DMA were resolved by Lorentzian-Gaussian product function. The equilibrium constants and thermodynamic parameters for the hydrogen bonding have been evaluated by the analysis of the concentration and temperature dependent spectra for the very dilute carbon tetrachloride solutions.
유동층 과립 제조기를 이용한 여러가지 유입공기온도와 코팅액 분사속도로 제조된 아세트산아미노펜 마이크로캅셀의 평가
민신홍(Shin Hong Min),양중익(Joong Ik Yang),김근혁(Keun Hyeok Kim),정구충(Gu Choong Jheong) 한국약제학회 1986 Journal of Pharmaceutical Investigation Vol.16 No.4
Microencapsulated acetaminophen granule was prepared in a fluid bed granulator, using ethylcellulose as coating material. We studied the effect of two important control factors, inlet air temperature and liquid flow rate. To evaluate various acetaminophen granules which were prepared by different conditions (inlet air temperature; 40℃, 50℃, 60℃, liquid flow rate; 18㎖, 36㎖, 54㎖, 72㎖/min), we used scanning electron microscope, dissolution tester, sieve analyzer and bulk densitometer. From above results, it was found that at inlet air temperature 50℃ and liquid flow rate 54 ㎖/min we could obtain a smooth and continuous granule surface, a narrower granule size distribution and 90% dissolution time 30-40min.